Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Kevin M. Jude"'
Autor:
Buwei Huang, Brian Coventry, Marta T. Borowska, Dimitrios C. Arhontoulis, Marc Exposit, Mohamad Abedi, Kevin M. Jude, Samer F. Halabiya, Aza Allen, Cami Cordray, Inna Goreshnik, Maggie Ahlrichs, Sidney Chan, Hillary Tunggal, Michelle DeWitt, Nathaniel Hyams, Lauren Carter, Lance Stewart, Deborah H. Fuller, Ying Mei, K. Christopher Garcia, David Baker
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Cytokine release syndrome (CRS), commonly known as cytokine storm, is an acute systemic inflammatory response that is a significant global health threat. Interleukin-6 (IL-6) and interleukin-1 (IL-1) are key pro-inflammatory cytokines involv
Externí odkaz:
https://doaj.org/article/5f93a3f590e5444ea2f8d8872b6aedb3
Autor:
Gita C. Abhiraman, Theodora U.J. Bruun, Nathanael A. Caveney, Leon L. Su, Robert A. Saxton, Qian Yin, Shaogeng Tang, Mark M. Davis, Kevin M. Jude, K. Christopher Garcia
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112657- (2023)
Summary: Interleukin-21 (IL-21) plays a critical role in generating immunological memory by promoting the germinal center reaction, yet clinical use of IL-21 remains challenging because of its pleiotropy and association with autoimmune disease. To be
Externí odkaz:
https://doaj.org/article/ff558ab89c5744beb43d3fcb68643740
Publikováno v:
eLife, Vol 11 (2022)
Interleukin 27 (IL-27) is a heterodimeric cytokine that functions to constrain T cell-mediated inflammation and plays an important role in immune homeostasis. Binding of IL-27 to cell surface receptors, IL-27Rα and gp130, results in activation of re
Externí odkaz:
https://doaj.org/article/3d6af9ad64d24630be66e37e27f76a8f
Autor:
Xinbo Yang, Lee I. Garner, Ivan V. Zvyagin, Michael A. Paley, Ekaterina A. Komech, Kevin M. Jude, Xiang Zhao, Ricardo A. Fernandes, Lynn M. Hassman, Grace L. Paley, Christina S. Savvides, Simon Brackenridge, Max N. Quastel, Dmitriy M. Chudakov, Paul Bowness, Wayne M. Yokoyama, Andrew J. McMichael, Geraldine M. Gillespie, K. Christopher Garcia
Publikováno v:
Nature. 612:771-777
Human leucocyte antigen B*27 (HLA-B*27) is strongly associated with inflammatory diseases of the spine and pelvis (for example, ankylosing spondylitis (AS)) and the eye (that is, acute anterior uveitis (AAU))1. How HLA-B*27 facilitates disease remain
Autor:
Naotaka Tsutsumi, Somnath Mukherjee, Deepa Waghray, Claudia Y Janda, Kevin M Jude, Yi Miao, John S Burg, Nanda Gowtham Aduri, Anthony A Kossiakoff, Cornelius Gati, K Christopher Garcia
Publikováno v:
eLife, Vol 9 (2020)
Frizzleds (Fzd) are the primary receptors for Wnt morphogens, which are essential regulators of stem cell biology, yet the structural basis of Wnt signaling through Fzd remains poorly understood. Here we report the structure of an unliganded human Fz
Externí odkaz:
https://doaj.org/article/ba3f9afaf5564636a239b4ee91e21fd8
Autor:
Huilin Yang, Umut Y. Ulge, Alfredo Quijano-Rubio, Zachary J. Bernstein, David R. Maestas, Jung-Ho Chun, Wentao Wang, Jian-Xin Lin, Kevin M. Jude, Srujan Singh, Brian T. Orcutt-Jahns, Peng Li, Jody Mou, Liam Chung, Yun-Huai Kuo, Yasmin H. Ali, Aaron S. Meyer, Warren L. Grayson, Nicola M. Heller, K. Christopher Garcia, Warren J. Leonard, Daniel-Adriano Silva, Jennifer H. Elisseeff, David Baker, Jamie B. Spangler
Publikováno v:
Nature Chemical Biology.
Autor:
Niels Banhos Danneskiold-Samsøe, Deniz Kavi, Kevin M. Jude, Silas Boye Nissen, Lianna W. Wat, Laetitia Coassolo, Meng Zhao, Galia Asae Santana-Oikawa, Beatrice Blythe Broido, K. Christopher Garcia, Katrin J. Svensson
Publikováno v:
bioRxiv
Secreted proteins are extracellular ligands that play key roles in paracrine and endocrine signaling, classically by binding cell surface receptors. Experimental assays to identify new extracellular ligand-receptor interactions are challenging, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f966d9cef372446e9e6aabd7be027e
https://doi.org/10.1101/2023.03.16.531341
https://doi.org/10.1101/2023.03.16.531341
Autor:
Naotaka Tsutsumi, Sunhee Hwang, Deepa Waghray, Simon Hansen, Kevin M. Jude, Nan Wang, Yi Miao, Caleb R. Glassman, Nathanael A. Caveney, Claudia Y. Janda, Rami N. Hannoush, K. Christopher Garcia
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Wnt morphogens are critical for embryonic development and tissue regeneration. Canonical Wnts form ternary receptor complexes composed of tissue-specific Frizzled (Fzd) receptors together with the shared LRP5/6 coreceptors to initiate β-catenin sign
Autor:
Longxing Cao, Brian Coventry, Inna Goreshnik, Buwei Huang, William Sheffler, Joon Sung Park, Kevin M. Jude, Iva Marković, Rameshwar U. Kadam, Koen H. G. Verschueren, Kenneth Verstraete, Scott Thomas Russell Walsh, Nathaniel Bennett, Ashish Phal, Aerin Yang, Lisa Kozodoy, Michelle DeWitt, Lora Picton, Lauren Miller, Eva-Maria Strauch, Nicholas D. DeBouver, Allison Pires, Asim K. Bera, Samer Halabiya, Bradley Hammerson, Wei Yang, Steffen Bernard, Lance Stewart, Ian A. Wilson, Hannele Ruohola-Baker, Joseph Schlessinger, Sangwon Lee, Savvas N. Savvides, K. Christopher Garcia, David Baker
Publikováno v:
NATURE
The design of proteins that bind to a specific site on the surface of a target protein using no information other than the three-dimensional structure of the target remains a challenge1–5. Here we describe a general solution to this problem that st
Autor:
Tobias V Lanz, R Camille Brewer, Peggy P Ho, Kevin M Jude, Daniel Fernandez, Jae-Seung Moon, Ricardo A Fernandes, Alejandro M Gomez, Gabriel-Stefan Nadj, Christopher M Bartley, Ryan D Schubert, Isobel A Hawes, Sara E Vazquez, Manasi Iyer, J Bradley Zuchero, Bianca Teegen, Jeffrey E Dunn, Christopher B Lock, Lucas B Kipp, Victoria C Cotham, Beatrix M Ueberheide, Blake T Aftab, Mark S Anderson, Joseph L DeRisi, Michael R Wilson, Rachael JM Bashford-Rogers, Michael Platten, K Christopher Garcia, Lawrence Steinman, William H Robinson
Publikováno v:
Nature
Nature, vol 603, iss 7900
Nature, vol 603, iss 7900
Multiple sclerosis (MS) is a heterogenous autoimmune disease in which autoreactive lymphocytes attack the myelin sheath of the central nervous system. B lymphocytes in the cerebrospinal fluid (CSF) of patients with MS contribute to inflammation and s