Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease

Autor: Tatyana Sukonnik, Fei Gu, Maximilian Haeussler, W. Patrick Devine, Reuben Thomas, Kavitha S. Rao, Michael H. Lai, Matthew L. Speir, William T. Pu, Irfan S. Kathiriya, Piyush Goyal, Bayardo I. Garay, Jonathan G. Seidman, Kai Li, Swetansu K. Hota, Andrew Blair, Benoit G. Bruneau, Henry Gong, Laure D. Bernard, Gunes A. Akgun, Holger Heyn, Lauren K. Wasson, Joshua M. Stuart, Giovanni Iacono, Kevin M. Hu, Brynn N. Akerberg, Christine E. Seidman

Publikováno v: Dev Cell
Developmental cell, vol 56, iss 3

Haploinsufficiency of transcriptional regulators causes human congenital heart disease (CHD); however, the underlying CHD gene regulatory network (GRN) imbalances are unknown. Here, we define transcriptional consequences of reduced dosage of the CHD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1355dc6ae49133bf02d2f38d8f2d4b43
https://doi.org/10.1016/j.devcel.2020.11.020

Planck Dust Polarization Power Spectra Are Consistent with Strongly Supersonic Turbulence

Autor: Kye A. Stalpes, David C. Collins, Kevin M. Huffenberger

Publikováno v: The Astrophysical Journal, Vol 972, Iss 1, p 26 (2024)

The polarization of the cosmic microwave background is rich in information but obscured by foreground emission from the Milky Way’s interstellar medium (ISM). To uncover relationships between the underlying turbulent ISM and the foreground power sp

Externí odkaz: https://doaj.org/article/f59f1c1534ff4d6e937f3d0160cacefb

The Atacama Cosmology Telescope: DR6 Gravitational Lensing Map and Cosmological Parameters

Autor: Mathew S. Madhavacheril, Frank J. Qu, Blake D. Sherwin, Niall MacCrann, Yaqiong Li, Irene Abril-Cabezas, Peter A. R. Ade, Simone Aiola, Tommy Alford, Mandana Amiri, Stefania Amodeo, Rui An, Zachary Atkins, Jason E. Austermann, Nicholas Battaglia, Elia Stefano Battistelli, James A. Beall, Rachel Bean, Benjamin Beringue, Tanay Bhandarkar, Emily Biermann, Boris Bolliet, J Richard Bond, Hongbo Cai, Erminia Calabrese, Victoria Calafut, Valentina Capalbo, Felipe Carrero, Anthony Challinor, Grace E. Chesmore, Hsiao-mei Cho, Steve K. Choi, Susan E. Clark, Rodrigo Córdova Rosado, Nicholas F. Cothard, Kevin Coughlin, William Coulton, Kevin T. Crowley, Roohi Dalal, Omar Darwish, Mark J. Devlin, Simon Dicker, Peter Doze, Cody J. Duell, Shannon M. Duff, Adriaan J. Duivenvoorden, Jo Dunkley, Rolando Dünner, Valentina Fanfani, Max Fankhanel, Gerrit Farren, Simone Ferraro, Rodrigo Freundt, Brittany Fuzia, Patricio A. Gallardo, Xavier Garrido, Jahmour Givans, Vera Gluscevic, Joseph E. Golec, Yilun Guan, Kirsten R. Hall, Mark Halpern, Dongwon Han, Ian Harrison, Matthew Hasselfield, Erin Healy, Shawn Henderson, Brandon Hensley, Carlos Hervías-Caimapo, J. Colin Hill, Gene C. Hilton, Matt Hilton, Adam D. Hincks, Renée Hložek, Shuay-Pwu Patty Ho, Zachary B. Huber, Johannes Hubmayr, Kevin M. Huffenberger, John P. Hughes, Kent Irwin, Giovanni Isopi, Hidde T. Jense, Ben Keller, Joshua Kim, Kenda Knowles, Brian J. Koopman, Arthur Kosowsky, Darby Kramer, Aleksandra Kusiak, Adrien La Posta, Alex Lague, Victoria Lakey, Eunseong Lee, Zack Li, Michele Limon, Martine Lokken, Thibaut Louis, Marius Lungu, Amanda MacInnis, Diego Maldonado, Felipe Maldonado, Maya Mallaby-Kay, Gabriela A. Marques, Jeff McMahon, Yogesh Mehta, Felipe Menanteau, Kavilan Moodley, Thomas W. Morris, Tony Mroczkowski, Sigurd Naess, Toshiya Namikawa, Federico Nati, Laura Newburgh, Andrina Nicola, Michael D. Niemack, Michael R. Nolta, John Orlowski-Scherer, Lyman A. Page, Shivam Pandey, Bruce Partridge, Heather Prince, Roberto Puddu, Federico Radiconi, Naomi Robertson, Felipe Rojas, Tai Sakuma, Maria Salatino, Emmanuel Schaan, Benjamin L. Schmitt, Neelima Sehgal, Shabbir Shaikh, Carlos Sierra, Jon Sievers, Cristóbal Sifón, Sara Simon, Rita Sonka, David N. Spergel, Suzanne T. Staggs, Emilie Storer, Eric R. Switzer, Niklas Tampier, Robert Thornton, Hy Trac, Jesse Treu, Carole Tucker, Joel Ullom, Leila R. Vale, Alexander Van Engelen, Jeff Van Lanen, Joshiwa van Marrewijk, Cristian Vargas, Eve M. Vavagiakis, Kasey Wagoner, Yuhan Wang, Lukas Wenzl, Edward J. Wollack, Zhilei Xu, Fernando Zago, Kaiwen Zheng

Publikováno v: The Astrophysical Journal, Vol 962, Iss 2, p 113 (2024)

We present cosmological constraints from a gravitational lensing mass map covering 9400 deg ^2 reconstructed from measurements of the cosmic microwave background (CMB) made by the Atacama Cosmology Telescope (ACT) from 2017 to 2021. In combination wi

Externí odkaz: https://doaj.org/article/8b29e912ccfb4e449d161f886c84331d

The Legacy of COVID-19: Revivifying the Socratic Method for the Benefit of Legal Education in Civil Law Countries

Autor: Kevin M. Hubacher

Publikováno v: Journal of Ethics and Legal Technologies, Vol 3, Iss 1, Pp 27-58 (2021)

A crisis marks a turning point for an entire society or a social subsystem by challenging old but not yet abandoned conceptions. In civil law countries, the infectious disease COVID-19 has led to a crisis in legal education. Despite many technologica

Externí odkaz: https://doaj.org/article/3a32f5314fc34d4996847ab0c394841e

Influence of YES1 Kinase and Tyrosine Phosphorylation on the Activity of OCT1

Autor: Muhammad Erfan Uddin, Dominique A. Garrison, Kyeongmin Kim, Yan Jin, Eric D. Eisenmann, Kevin M. Huang, Alice A. Gibson, Zeping Hu, Alex Sparreboom, Shuiying Hu

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

Organic cation transporter 1 (OCT1) is a transporter that regulates the hepatic uptake and subsequent elimination of diverse cationic compounds. Although OCT1 has been involved in drug-drug interactions and causes pharmacokinetic variability of many

Externí odkaz: https://doaj.org/article/a6dbe5702d4247bd97e9ee03b9c3bc14