Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Kevin M. Harlen"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Many neurodegenerative diseases induce high levels of sustained cellular stress and alter a number of cellular processes. To examine how different mutations associated with neurodegenerative disease affect cell stress and signaling, we created live-c
Externí odkaz:
https://doaj.org/article/e1322e664d264c2599b645d397ac6d4f
Autor:
Kevin M. Harlen, Kristine L. Trotta, Erin E. Smith, Mohammad M. Mosaheb, Stephen M. Fuchs, L. Stirling Churchman
Publikováno v:
Cell Reports, Vol 15, Iss 10, Pp 2147-2158 (2016)
Transcription controls splicing and other gene regulatory processes, yet mechanisms remain obscure due to our fragmented knowledge of the molecular connections between the dynamically phosphorylated RNA polymerase II (Pol II) C-terminal domain (CTD)
Externí odkaz:
https://doaj.org/article/1dabfdeb9f0e41caa4a93ad2a6832f61
Autor:
Mary Couvillion, Kevin M Harlen, Kate C Lachance, Kristine L Trotta, Erin Smith, Christian Brion, Brendan M Smalec, L Stirling Churchman
Publikováno v:
eLife, Vol 11 (2022)
Understanding the complex network that regulates transcription elongation requires the quantitative analysis of RNA polymerase II (Pol II) activity in a wide variety of regulatory environments. We performed native elongating transcript sequencing (NE
Externí odkaz:
https://doaj.org/article/423671e31f8c4a3383b5bd9ff2afd815
Autor:
Kevin M Harlen, L Stirling Churchman
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 1, Pp 1-14 (2017)
Abstract Transcription, RNA processing, and chromatin‐related factors all interact with RNA polymerase II (Pol II) to ensure proper timing and coordination of transcription and co‐transcriptional processes. Many transcription elongation regulator
Externí odkaz:
https://doaj.org/article/879d18a351064d04b8a15d52037ae01f
Autor:
Kate C Lachance, Kevin M Harlen, Mary Couvillion, Kristine L Trotta, Erin Smith, Christian Brion, Brendan M Smalec, L Stirling Churchman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53db5023a0425711612c638e9b5987e5
https://doi.org/10.7554/elife.78944.sa2
https://doi.org/10.7554/elife.78944.sa2
Autor:
Kate C Lachance, Kevin M Harlen, Mary Couvillion, Kristine L Trotta, Erin Smith, Christian Brion, Brendan M Smalec, L Stirling Churchman
Publikováno v:
eLife. 11
Understanding the complex network that regulates transcription elongation requires the quantitative analysis of RNA polymerase II (Pol II) activity in a wide variety of regulatory environments. We performed native elongating transcript sequencing (NE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbcd2755b8a334d97d1add05c52624c9
https://pubmed.ncbi.nlm.nih.gov/35575476
https://pubmed.ncbi.nlm.nih.gov/35575476
Autor:
Kristine Trotta, Christian Brion, Kate C. Lachance, Brendan M. Smalec, Mary T. Couvillion, Kevin M. Harlen, Erin E. Smith, L. Stirling Churchman
Understanding the complex network and dynamics that regulate transcription elongation requires the quantitative analysis of RNA polymerase II (Pol II) activity in a wide variety of regulatory environments. We performed native elongating transcript se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48e378090a16d7c98f5de209eeeb2958
https://doi.org/10.1101/2021.08.15.456358
https://doi.org/10.1101/2021.08.15.456358
Publikováno v:
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Many neurodegenerative diseases induce high levels of sustained cellular stress and alter a number of cellular processes. To examine how different mutations associated with neurodegenerative disease affect cell stress and signaling, we created live-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9736533cf2de817a0b9160c794427c4a
https://doi.org/10.1101/735878
https://doi.org/10.1101/735878
Publikováno v:
Biophysical Journal. 118:456a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::395637d9db0dffcfaa190eeeb4af0a9c
https://doi.org/10.1016/j.bpj.2019.11.2540
https://doi.org/10.1016/j.bpj.2019.11.2540
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49e487b2f3a35cf8561e4b8612e1af42
https://doi.org/10.1096/fasebj.2018.32.1_supplement.lb639
https://doi.org/10.1096/fasebj.2018.32.1_supplement.lb639