Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kevin M. Doherty"'
Autor:
Sharon B. Cantor, Kevin M. Doherty, Robert M. Brosh, Joshua A. Sommers, Rigu Gupta, Sudha Sharma
Publikováno v:
Nucleic Acids Research
The BRCA1 associated C-terminal helicase (BACH1) associated with breast cancer has been implicated in double strand break (DSB) repair. More recently, BACH1 (FANCJ) has been genetically linked to the chromosomal instability disorder Fanconi Anemia (F
Autor:
Robert M. Brosh, Saba Choudhary, Jane M. Sayer, Donald M. Jerina, Haruhiko Yagi, Christopher J. Handy, Kevin M. Doherty
Publikováno v:
Journal of Biological Chemistry. 281:6000-6009
RecQ helicases are believed to function in repairing replication forks stalled by DNA damage and may also play a role in the intra-S-phase checkpoint, which delays the replication of damaged DNA, thus permitting repair to occur. Since little is known
Autor:
Jin-Shan Hu, Guang-Xin Lin, Robert M. Brosh, Jae Wan Lee, Kevin M. Doherty, Wen-Hsing Cheng, Cayetano von Kobbe, Wangyong Zeng, Rika Kusumoto, Vilhelm A. Bohr
Publikováno v:
Journal of Biological Chemistry. 280:39627-39636
Naturally occurring mutations in the human RECQ3 gene result in truncated Werner protein (WRN) and manifest as a rare premature aging disorder, Werner syndrome. Cellular and biochemical studies suggest a multifaceted role of WRN in DNA replication, D
Autor:
Teresa M. Wilson, Robert M. Brosh, Laura A. Uzdilla, Kevin M. Doherty, Alessandro Vindigni, Sudha Sharma, Sheng Cui
Publikováno v:
Journal of Biological Chemistry. 280:28085-28094
Understanding the molecular and cellular functions of RecQ helicases has attracted considerable interest since several human diseases characterized by premature aging and/or cancer have been genetically linked to mutations in genes of the RecQ family
Publikováno v:
Current Medicinal Chemistry-Anti-Cancer Agents. 5:183-199
DNA helicases have essential roles in nucleic acid metabolism by facilitating cellular processes including replication, recombination, DNA repair, and transcription. The vital roles of helicases in these pathways are reflected by their emerging impor
Autor:
Kevin M. Doherty, Robert M. Brosh, Parimal Karmakar, Joshua A. Sommers, Mark K. Kenny, Qin Yang, Curtis C. Harris, Sudha Sharma
Publikováno v:
Cancer Research. 65:1223-1233
Werner syndrome is a hereditary disorder characterized by the early onset of age-related symptoms, including cancer. The absence of a p53-WRN helicase interaction may disrupt the signal to direct S-phase cells into apoptosis for programmed cell death
Autor:
Ajay Pramanik, James Lukose, Kevin M. Doherty, Eric G D Muller, David Botstein, Ronald Charles, Brian E. Snydsman, Carol Wood Moore, Leah D. Pride
Publikováno v:
G3: Genes|Genomes|Genetics
Cytoprotective functions of a 20S proteasome activator were investigated. Saccharomyces cerevisiae [Blm10][1] and human 20S proteasome activator 200 (PA200) are homologs. Comparative genome-wide analyses of untreated diploid cells lacking [Blm10][1]
Publikováno v:
Recent patents on anti-cancer drug discovery. 1(2)
Increasing evidence suggests that four-stranded tetraplex structures spontaneously form under physiological conditions and these alternate DNA structures are likely to form in vivo. Alternate G-quadruplex DNA structures that may form in regulatory el
Helicases are molecular motor proteins that couple the hydrolysis of NTP to nucleic acid unwinding. The growing number of DNA helicases implicated in human disease suggests that their vital specialized roles in cellular pathways are important for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469d9b5b97e58db58ab354a927bb4cc6
https://europepmc.org/articles/PMC1559444/
https://europepmc.org/articles/PMC1559444/
Autor:
Kevin M. Doherty, Matthew D. Gray, Mark K. Kenny, Cayetano von Kobbe, Jae Wan Lee, Robert M. Brosh, Raichal P. Kureekattil, Nicolas H. Thomä, Joshua A. Sommers
Publikováno v:
The Journal of biological chemistry. 280(33)
The single-stranded DNA-binding protein replication protein A (RPA) interacts with several human RecQ DNA helicases that have important roles in maintaining genomic stability; however, the mechanism for RPA stimulation of DNA unwinding is not well un