Zobrazeno 1 - 10
of 306
pro vyhledávání: '"Kevin M. Crofton"'
Autor:
European Food Safety Authority (EFSA), Kevin M. Crofton, Martin Paparella, Anna Price, Iris Mangas, Laura Martino, Andrea Terron, Antonio Hernández‐Jerez
Publikováno v:
EFSA Journal, Vol 22, Iss 8, Pp n/a-n/a (2024)
Abstract The adverse outcome pathway (AOP) framework serves as a practical tool for organising scientific knowledge that can be used to infer cause–effect relationships between stressor events and toxicity outcomes in intact organisms. However, a m
Externí odkaz:
https://doaj.org/article/c3b3bb85a2de473da5a703e2851b6664
Autor:
Center, Mary Beth, Crofton, Kevin M.
Publikováno v:
Experimental and Clinical Neurotoxicology.
Externí odkaz:
https://doi.org/10.1093/oso/9780195084771.003.0348
Autor:
Candice, Johnson, Lennart T, Anger, Romualdo, Benigni, David, Bower, Frank, Bringezu, Kevin M, Crofton, Mark T D, Cronin, Kevin P, Cross, Magdalena, Dettwiler, Markus, Frericks, Fjodor, Melnikov, Scott, Miller, David W, Roberts, Diana, Suarez-Rodriguez, Alessandra, Roncaglioni, Elena, Lo Piparo, Raymond R, Tice, Craig, Zwickl, Glenn J, Myatt
Publikováno v:
Comput Toxicol
Understanding the reliability and relevance of a toxicological assessment is important for gauging the overall confidence and communicating the degree of uncertainty related to it. The process involved in assessing reliability and relevance is well d
Autor:
Jonathan Blum, Stefan Masjosthusmann, Kristina Bartmann, Farina Bendt, Xenia Dolde, Arif Dönmez, Nils Förster, Anna-Katharina Holzer, Ulrike Hübenthal, Hagen Eike Keßel, Sadiye Kilic, Jördis Klose, Melanie Pahl, Lynn-Christin Stürzl, Iris Mangas, Andrea Terron, Kevin M. Crofton, Martin Scholze, Axel Mosig, Marcel Leist, Ellen Fritsche
Developmental neurotoxicity (DNT) is a major safety concern for all chemicals of the human exposome. However, DNT data from animal studies are available for only a small percentage of manufactured compounds. Test methods with a higher throughput than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04065f0054d0235280408ccf7d7668ba
https://zenodo.org/record/7752644
https://zenodo.org/record/7752644
Autor:
William R. Mundy, Kevin M Crofton
Publikováno v:
EFSA Supporting Publications. 18
Autor:
Kevin M. Crofton, Arianna Bassan, Mamta Behl, Yaroslav G. Chushak, Ellen Fritsche, Jeffery M. Gearhart, Mary Sue Marty, Moiz Mumtaz, Manuela Pavan, Patricia Ruiz, Magdalini Sachana, Rajamani Selvam, Timothy J. Shafer, Lidiya Stavitskaya, David T. Szabo, Steven T. Szabo, Raymond R. Tice, Dan Wilson, David Woolley, Glenn J. Myatt
Publikováno v:
Comput Toxicol
Neurotoxicology is the study of adverse effects on the structure or function of the developing or mature adult nervous system following exposure to chemical, biological, or physical agents. The development of more informative alternative methods to a
Autor:
Anna Bal-Price, Andrea Terron, Kevin M Crofton, Timothy J. Shafer, Magdalini Sachana, Susanne Hougaard Bennekou, Mamta Behl
Publikováno v:
Toxicological Sciences. 167:45-57
The Organisation for Economic Co-Operation and Development (OECD) coordinates international efforts to enhance developmental neurotoxicity (DNT) testing. In most regulatory sectors, including the ones dealing with pesticides and industrial chemicals
Autor:
John R. Bucher, Mahmoud Shobair, Paul Shinn, Adam Yasgar, Inthirany Thillainadarajah, Chihae Yang, Richard S. Paules, Bradley J. Collins, Ann M. Richard, Anton Simeonov, Ruili Huang, Suzanne Fitzpatrick, Kevin M. Crofton, Keith A. Houck, Robert J. Kavlock, Christopher M. Grulke, Suramya Waidyanatha, James F. Rathman, Raymond R. Tice, Ryan Lougee, Richard S. Judson, Christopher P. Austin, Russell S. Thomas, Antony J. Williams
Publikováno v:
Chem Res Toxicol
[Image: see text] Since 2009, the Tox21 project has screened ∼8500 chemicals in more than 70 high-throughput assays, generating upward of 100 million data points, with all data publicly available through partner websites at the United States Enviro
Autor:
Glenn J. Myatt, Arianna Bassan, Dave Bower, Kevin M. Crofton, Kevin P. Cross, Jessica C. Graham, Catrin Hasselgren, Robert A. Jolly, Scott Miller, Manuela Pavan, Raymond R Tice, Craig Zwickl, Candice Johnson
Publikováno v:
Computational Toxicology. 21:100209
Autor:
Elena Martsen, Kristen L Gorman, Keith A. Houck, Sergei S. Makarov, Kevin M Crofton, Lyubov A Medvedeva, Alexander Medvedev, Benjamin Lin, Mathew Moeser, Daniel L. Villeneuve, Brett R. Blackwell
Publikováno v:
Environmental sciencetechnology. 54(19)
Environmental pollution is a threat to humans and wildlife species. Of particular concern are endocrine disrupting chemicals (EDCs). An important target of EDCs is nuclear receptors (NRs) that control endocrine and metabolic responses through transcr