Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kevin M. Conlon"'
Autor:
Adam M. Dinan, Pin Tong, Amanda J. Lohan, Kevin M. Conlon, Aleksandra A. Miranda-CasoLuengo, Kerri M. Malone, Stephen V. Gordon, Brendan J. Loftus
Publikováno v:
mBio, Vol 5, Iss 4 (2014)
ABSTRACT Related species are often used to understand the molecular underpinning of virulence through examination of a shared set of biological features attributable to a core genome of orthologous genes. An important but insufficiently studied issue
Externí odkaz:
https://doaj.org/article/dfb4712138a24332a916eb22066a1dc4
Autor:
David A Magee, Maria Taraktsoglou, Kate E Killick, Nicolas C Nalpas, John A Browne, Stephen D E Park, Kevin M Conlon, David J Lynn, Karsten Hokamp, Stephen V Gordon, Eamonn Gormley, David E MacHugh
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32034 (2012)
BACKGROUND: Mycobacterium bovis, the causative agent of bovine tuberculosis, is a major cause of mortality in global cattle populations. Macrophages are among the first cell types to encounter M. bovis following exposure and the response elicited by
Externí odkaz:
https://doaj.org/article/5e87511b90d04aa98a259781e9dfb1c5
Autor:
Kerri M. Malone, Eamonn Gormley, David A. Magee, Stephen V. Gordon, Kevin M. Conlon, John A. Browne, Alicia Smyth, David E. MacHugh, Ruedi Aebersold, Olga T. Schubert, Nicolas C. Nalpas, Kevin Rue-Albrecht
Publikováno v:
Microbial Genomics
Microbial Genomics, 4 (3)
Microbial Genomics, 4 (3)
Members of the Mycobacterium tuberculosis complex (MTBC) are the causative agents of tuberculosis in a range of mammals, including humans. A key feature of MTBC pathogens is their high degree of genetic identity, yet distinct host tropism. Notably, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9341d4c15388a59a639c4e3019c5fc7c
https://doi.org/10.1099/mgen.0.000163
https://doi.org/10.1099/mgen.0.000163
Autor:
Nicolas C. Nalpas, Stephen V. Gordon, Kevin M. Conlon, David A. Magee, David J. Lynn, David E. MacHugh, Amir Foroushani, Matthew S. McCabe, John A. Browne, Daniel G. Bradley, Peter Vegh
Publikováno v:
Veterinary Immunology and Immunopathology. 155:238-244
MicroRNAs (miRNAs) are important regulators of gene expression and are known to play a key role in regulating both adaptive and innate immunity. Bovine alveolar macrophages (BAMs) help maintain lung homeostasis and constitute the front line of host d
Autor:
Guillaume Garnier, Jean-Yves Coppée, Amanda J. Lohan, Mickael Orgeur, Roland Brosch, Jean-Louis Gaillard, Nadine Honoré, Pin Tong, Anne-Laure Roux, Fabien Le Chevalier, Stephen V. Gordon, Alexandre Pawlik, Laurence Ma, Marie-Agnès Dillies, Guillaume Sapriel, Kevin M. Conlon, Christiane Bouchier, Jean-Louis Herrmann, Brendan J. Loftus
Publikováno v:
Molecular Microbiology. 90:612-629
Summary Mycobacterium abscessus is an emerging pathogen that is increasingly recognized as a relevant cause of human lung infection in cystic fibrosis patients. This highly antibiotic-resistant mycobacterium is an exception within the rapidly growing
Autor:
Paul A. McGettigan, David E. MacHugh, Eamonn Gormley, John A. Browne, Claire Healy, Kevin M. Conlon, Kirsten E. McLoughlin, Stephen V. Gordon, Kate E. Killick, David A. Magee, Nicolas C. Nalpas, Kevin Rue-Albrecht
Publikováno v:
Scientific Reports
Mycobacterium bovis, the agent of bovine tuberculosis, causes an estimated $3 billion annual losses to global agriculture due, in part, to the limitations of current diagnostics. Development of next-generation diagnostics requires a greater understan
Autor:
David E. MacHugh, Kevin M. Conlon, Kenneth Bryan, David A. Magee, Matthew S. McCabe, David J. Lynn, Stephen V. Gordon, Daniel G. Bradley, Peter Vegh, John A. Browne, Nicolas C. Nalpas
peer-reviewed Mycobacterium bovis, the causative agent of bovine tuberculosis, a major problem for global agriculture, spreads via an airborne route and is taken up by alveolar macrophages (AM) in the lung. Here, we describe the first next-generation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8ffbd429b67fef66e3bd4852799f3b
http://hdl.handle.net/11019/2102
http://hdl.handle.net/11019/2102
Publikováno v:
Journal of Bacteriology. 186:6208-6219
Expression of ica operon-mediated biofilm formation in Staphylococcus epidermidis RP62A is subject to phase variable regulation. Reversible transposition of IS 256 into icaADBC or downregulation of icaADBC expression are two important mechanisms of b
Autor:
James P. O'Gara, Kevin M. Conlon, Paul D. Fey, Luke D. Handke, Shawn R. Slater, S. Elbaruni, Fidelma Fitzpatrick, Hilary Humphreys, W. P. Giles, Mark E. Rupp
Publikováno v:
Journal of Medical Microbiology. 53:367-374
Production of biofilm in Staphylococcus epidermidis is mediated through enzymes produced by the four-gene operon ica and is subject to phenotypic variation. The purpose of these experiments was to investigate the regulation of ica and icaR transcript
Publikováno v:
FEMS Microbiology Letters. 216:171-177
LightCycler and conventional reverse transcription-polymerase chain reaction (RT-PCR) were used to examine regulation of icaR, which encodes a repressor of the Staphylococcus epidermidis ica operon. Varying concentrations of NaCl and ethanol activate