Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Kevin M. Byrne"'
Autor:
Hiranthi Jayasuriya, Gabe Dezeny, Mary Motyl, Francisca Vicente, Joann Huber, Angela Basilio, Deborah L. Zink, Kevin M. Byrne, Javier Collado, Sheo B. Singh, Mary Lee Goldman, Gerald F. Bills
Publikováno v:
The Journal of Antibiotics. 62:265-269
Treatment of drug-resistant bacteria is a significant unmet medical need. This challenge can be met only by the discovery and development of new antibiotics. Antisense technology is one of the newest discovery tools that provides enhanced sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da4b57cbed74e6656008fc49e60ca6bd
https://doi.org/10.1038/ja.2009.26
https://doi.org/10.1038/ja.2009.26
Autor:
Kevin M. Byrne, Angela Basilio, Mary Motyl, Sheo B. Singh, Francisca Vicente, Karen Dorso, Sookhee Ha, Deborah L. Zink, Olga Genilloud, Oscar Salazar
Publikováno v:
Journal of Natural Products. 72:345-352
Bacterial resistance to existing antibiotics continues to grow, necessitating the discovery of new compounds of this type. Antisense-based whole-cell target-based screening is a new and highly sensitive antibiotic discovery approach that has led to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec4996311cac4de550fe1652754f9b0f
https://doi.org/10.1021/np8005106
https://doi.org/10.1021/np8005106
Autor:
Javier Collado, Mary Motyl, Gonzalo Platas, Deborah L. Zink, Angela Basilio, John G. Ondeyka, Francisca Vicente, Chaowei Zhang, Gerald F. Bills, Joann Huber, Karen Dorso, Kevin M. Byrne, Sheo B. Singh
Publikováno v:
Journal of Natural Products. 71:1304-1307
Ribosomal protein S4 (RPSD), a part of the ribosomal small subunit, is one of the proteins that is a part of the ribosomal machinery and is a potential new target for the discovery of antibacterial agents. Continued screening of microbial extracts us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5660951b25c10989094ab8464986cb2d
https://doi.org/10.1021/np8001833
https://doi.org/10.1021/np8001833
Autor:
Kevin M. Byrne, M. Teresa Díez, Joanne Huber, Oscar Salazar, Deborah L. Zink, Olga Genilloud, Sheo B. Singh, Francisca Vicente, Angela Basilio
Publikováno v:
Organic Letters. 8:5449-5452
Inhibition of protein synthesis is one of the validated and highly successful targets for inhibition of bacterial growth; this mechanism is a target of a large number of clinical drugs. Ribosomal protein S4, a primary protein, is a potential target f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf055069e72c4994bcd9ab726b07999
https://doi.org/10.1021/ol062041r
https://doi.org/10.1021/ol062041r
Autor:
John G. Ondeyka, Angela Basilio, Gabe Dezeny, Kevin M. Byrne, Sheo B. Singh, Francisca Vicente, Mary Motyl, Maria Teresa Diez, Gerald F. Bills, Deborah L. Zink
Publikováno v:
Journal of Natural Products. 70:668-670
Bacterial protein synthesis inhibitors interact mainly with rRNA and to some extent ribosomal proteins, which are potential targets for developing new antibacterial agents. Specifically, the ribosomal protein S4 of the 30s ribosomal subunit known as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8db1c0ad17add3d5ba2902cde93526a
https://doi.org/10.1021/np060557d
https://doi.org/10.1021/np060557d
Autor:
Leeyuan Huang, Maria Teresa Diez-Matas, Claude Dufresne, Marina Mojena, Rosalind G. Jenkins, Kevin M. Byrne, Fernando Pelaez, Gerald F. Bills, Jon D. Polishook, Guy H. Harris, Wendy H. Clapp, Mary Nallin-Omstead, James D. Bergstrom
Publikováno v:
Mycological Research. 98:733-739
The search for squalene synthase inhibitors of microbial origin has resulted in the discovery of a new class of fungal metabolites, the zaragozic acids (squalestatins). During our survey of representatives of most major groups of fungi and filamentou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::603f1b631f1fa48f8d7f95e2641204d8
https://doi.org/10.1016/s0953-7562(09)81046-0
https://doi.org/10.1016/s0953-7562(09)81046-0
Publikováno v:
The Journal of Organic Chemistry. 58:1019-1024
The biosynthetic precursors of zaragozic acid A, a member of a new class of squalene synthase inhibitors, were determined. Washed cells of the producing culture, an unidentified sterile fungus, were supplemented with both 14 C- and 13 C-labeled sustr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eeaa3953813af6b8cf3df8207537ea8b
https://doi.org/10.1021/jo00057a010
https://doi.org/10.1021/jo00057a010
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38158a5d713bebacba116cbb437d3fd2
https://doi.org/10.1002/chin.199322274
https://doi.org/10.1002/chin.199322274
Publikováno v:
Biochemistry. 30:5789-5796
Immunomycin, an immunosuppressant closely related to FK 506, contains a pipecolate residue in amide linkage with an acyl group in its polyketide backbone. An enzyme activating L-pipecolic acid has been isolated from Streptomyces hygroscopicus var. as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49891f37e9b972d675d9c593eed020ec
https://doi.org/10.1021/bi00237a023
https://doi.org/10.1021/bi00237a023
Autor:
Javier Collado, John G. Ondeyka, Joann Huber, Gonzalo Platas, Francisca Vicente, Mary Motyl, Chaowei Zhang, Deborah L. Zink, Karen Dorso, Angela Basilio, Kevin M. Byrne, Sheo B. Singh
Publikováno v:
Bioorganicmedicinal chemistry. 17(6)
Protein synthesis is one of the best antibacterial targets that have led to the development of a number of highly successful clinical drugs. Protein synthesis is catalyzed by ribosome, which is comprised of a number of ribosomal proteins that help th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5adfca44ae5504ad1783919b935da50
https://pubmed.ncbi.nlm.nih.gov/18442914
https://pubmed.ncbi.nlm.nih.gov/18442914