Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kevin M. Beggs"'
Publikováno v:
International Journal of Toxicology. 37:383-392
Perfluorooctanesulfonic acid (PFOS) is a persistent organic pollutant with worldwide bioaccumulation due to a very long half-life. Perfluorooctanesulfonic acid exposure results in significant hepatic effects including steatosis, proliferation, hepato
Autor:
Kevin M. Beggs, Jed N. Lampe, Sumedha Gunewardena, Steven R. McGreal, Christoper Lau, Alex McCarthy, Udayan Apte
Publikováno v:
Toxicology and Applied Pharmacology. 304:18-29
Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), chemicals present in a multitude of consumer products, are persistent organic pollutants. Both compounds induce hepatotoxic effects in rodents, including steatosis, hepatomegaly a
Autor:
Hua Li, Udayan Apte, Maura O'Neil, Nairita Roy, Lina Sun, Bharat Bhushan, Genea Edwards, Kevin M. Beggs, Prachi Borude, Sumedha Gunewardena, Michael W. Manley, Chad Walesky
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 311:G91-G104
Hepatocellular carcinoma (HCC) is the most common hepatic malignancy and the third leading cause of cancer related deaths. Previous studies have implicated bile acids in pathogenesis of HCC, but the mechanisms are not known. We investigated the mecha
Autor:
Patrick J. Shaw, Robert A. Roth, Erica M. Sparkenbaugh, Christine M. Dugan, Kevin M. Beggs, Patricia E. Ganey
Publikováno v:
Toxicological Sciences. 111:288-301
Therapy employing the fluoroquinolone antibiotic, trovafloxacin (TVX) was curtailed due to idiosyncratic hepatotoxicity. Previous studies in mice showed that a nonhepatotoxic inflammatory stress induced by tumor necrosis factor alpha (TNF) synergized
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 350(1)
Trovafloxacin (TVX) is a drug that has caused idiosyncratic, drug-induced liver injury (IDILI) in humans. In a murine model of IDILI, otherwise nontoxic doses of TVX and the inflammagen lipopolysaccharide (LPS) interacted to produce pronounced hepato
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 137(1)
Idiosyncratic drug-induced liver injury (IDILI) continues to be a significant human health problem. IDILI is characterized as occurring in a minority of individuals exposed to a drug, yet it accounts for as much as 17% of all cases of acute liver fai
Autor:
Kevin M. Beggs, A. Daniel Jones, Patricia E. Ganey, Erica M. Sparkenbaugh, Wei Zou, Robert A. Roth, Husam S. Younis
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 331(1)
Sulindac (SLD) is a nonsteroidal anti-inflammatory drug (NSAID) that has been associated with a greater incidence of idiosyncratic hepatotoxicity in human patients than other NSAIDs. In previous studies, cotreatment of rats with SLD and a modestly in
Autor:
Robert A. Roth, Patricia E. Ganey, Erica M. Sparkenbaugh, Kevin M. Beggs, A. Daniel Jones, Wei Zou
Publikováno v:
The FASEB Journal. 23
Publikováno v:
Clinical and experimental pharmacologyphysiology. 36(5-6)
SUMMARY 1 Our goal was to investigate the body distribution of serotonin (5-hydroxytryptamine; 5-HT) in rats infused with 5-HT (25 µg/kg per min) for 7 days and the contribution of the 5-HT transporter (SERT) for 5-HT uptake into the tissues. 2 Mini