Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kevin M Tuffy"'
Autor:
Lindsay E Clegg, Oleg Stepanov, Sam Matthews, Tom White, Seth Seegobin, Steven Thomas, Kevin M Tuffy, Mats Någård, Mark T Esser, Katie Streicher, Taylor S Cohen, Anastasia A Aksyuk
Publikováno v:
Clinical & Translational Immunology, Vol 13, Iss 6, Pp n/a-n/a (2024)
Abstract Objectives The evolution of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) necessitates rapid methods for assessing monoclonal antibody (mAb) potency against emerging variants. Authentic virus neutralisation assays are cons
Externí odkaz:
https://doaj.org/article/d383527f067748c0a99eb961c96ff5ba
Autor:
Deidre Wilkins, Anastasia A Aksyuk, Alexey Ruzin, Kevin M Tuffy, Tina Green, Rebecca Greway, Brittany Fikes, Cyrille J Bonhomme, Mark T Esser, Elizabeth J Kelly
Publikováno v:
Clinical & Translational Immunology, Vol 11, Iss 4, Pp n/a-n/a (2022)
Abstract Objectives Robust, quantitative serology assays are required to accurately measure antibody levels following vaccination and natural infection. We present validation of a quantitative, multiplex, SARS‐CoV‐2, electrochemiluminescent (ECL)
Externí odkaz:
https://doaj.org/article/185998943a9c4bd88730c7fd662763ef
Autor:
Tiffany L. Roe, Tyler Brady, Nicolette Schuko, Amy Nguyen, Jagadish Beloor, Johnathan D. Guest, Anastasia A. Aksyuk, Kevin M. Tuffy, Tianhui Zhang, Katie Streicher, Elizabeth J. Kelly, Gustavo H. Kijak
Publikováno v:
Microbiology Spectrum. 11
MAbs are key therapeutic options for COVID-19 prophylaxis and treatment in immunosuppressed and vulnerable populations. Due to the emergence of SARS-CoV-2 variants, including Omicron, it is vital to ensure that neutralization is maintained for MAb-ba
Autor:
Deidre Wilkins, Annefleur C Langedijk, Robert Jan Lebbink, Christopher Morehouse, Michael E Abram, Bahar Ahani, Anastasia A Aksyuk, Eugenio Baraldi, Tyler Brady, Albert Tian Chen, Hsin Chi, Eun Hwa Choi, Robert Cohen, Daria M Danilenko, Vancheswaran Gopalakrishnan, Anne Greenough, Terho Heikkinen, Mitsuaki Hosoya, Christian Keller, Elizabeth J Kelly, Leyla Kragten-Tabatabaie, Federico Martinón-Torres, Abiel Homero Mascareñas de Los Santos, Marta C Nunes, María Angélica Palomino, Jesse Papenburg, Jeffrey M Pernica, Peter Richmond, Renato T Stein, Kevin M Tuffy, Charl Verwey, Mark T Esser, David E Tabor, Louis J Bont, Pascale Clement, Atul Gupta, Koichi Hashimoto, Kseniya Komissarova, Matt Laubscher, Magali Lumertz, Elena Priante, Irene Rivero-Calle, Ushma Wadia, Ki Wook Yun
Publikováno v:
The Lancet Infectious Diseases.
Autor:
Kevin M Tuffy, Michael E Abram, Tiffany L Roe, Bahar Ahani, Tyler Brady, Nicolette Schuko, Lori Clarke, Carolina Caceres, Tara Kenny, Virginia Takahashi, Tianhui Zhang, David E Tabor, Gustavo H Kijak, Elizabeth J Kelly, Katie Streicher
Publikováno v:
Open Forum Infectious Diseases. 9
Background AZD7442 is a combination of extended–half-life SARS-CoV-2–neutralizing monoclonal antibodies (tixagevimab/cilgavimab) that bind to distinct epitopes on the SARS-CoV-2 spike protein. In the PROVENT study, a single 300 mg intramuscular d
Autor:
Michael E Abram, Bahar Ahani, David E Tabor, Fiona Fernandes, Deidre Wilkins, Anastasia A Aksyuk, Kevin M Tuffy, Hong Ji, Christine Blaze, Tyler Brady, Pamela Griffin, Amanda Leach, Tonya L Villafana, Mark T Esser
Publikováno v:
Open Forum Infectious Diseases. 9
Background Respiratory syncytial virus (RSV) is the major cause of lower respiratory tract infection (LRTI) and hospitalization in infants. In two global pivotal placebo-controlled studies, nirsevimab, a monoclonal antibody to the RSV prefusion (F) p
Autor:
Kevin M. Tuffy, Rebecca J. Kaddis Maldonado, Jordan Chang, Paul Rosenfeld, Alan Cochrane, Leslie J. Parent
Publikováno v:
Viruses, Vol 12, Iss 11, p 1281 (2020)
The ability of the retroviral Gag protein of Rous sarcoma virus (RSV) to transiently traffic through the nucleus is well-established and has been implicated in genomic RNA (gRNA) packaging Although other retroviral Gag proteins (human immunodeficienc
Externí odkaz:
https://doaj.org/article/33ba0114dad24f4482398d2079ab8307
Autor:
Seth J. Zost, Matthew B. Frieman, Allison J. Greaney, Yueh-Ming Loo, Marisa McGrath, Elad Binshtein, Stuart Weston, James Brett Case, James Logue, James E. Crowe, Robert H. Carnahan, Helen Bright, Pei Yong Shi, Kevin M Tuffy, Tyler Brady, Rachel E. Sutton, Tyler N. Starr, Patrick M. McTamney, Jesse D. Bloom, Elaine C. Chen, Mark T. Esser, Adam S. Dingens, Xianwen Zhang, Rita E. Chen, Pavlo Gilchuk, Rachel S. Nargi, Jessica Rodriguez, Xuping Xie, Christopher Gainza, Erica Armstrong, Jinhui Dong, Michael S. Diamond
Publikováno v:
Nature Microbiology. 6:1233-1244
Understanding the molecular basis for immune recognition of SARS-CoV-2 spike glycoprotein antigenic sites will inform the development of improved therapeutics. We determined the structures of two human monoclonal antibodies-AZD8895 and AZD1061-which
Autor:
Tyler Brady, Tianhui Zhang, Kevin M. Tuffy, Nantaporn Haskins, Qun Du, Jia Lin, Gilad Kaplan, Steven Novick, Tiffany L. Roe, Kuishu Ren, Kim Rosenthal, Patrick M. McTamney, Michael E. Abram, Katie Streicher, Elizabeth J. Kelly
Publikováno v:
Microbiology Spectrum. 10
AZD7442, a combination of two long-acting monoclonal antibodies (tixagevimab [AZD8895] and cilgavimab [AZD1061]), has been authorized for the prevention and treatment of coronavirus disease 2019 (COVID-19). The rapid emergence of severe acute respira
Autor:
Deidre Wilkins, Anastasia A Aksyuk, Alexey Ruzin, Kevin M Tuffy, Tina Green, Rebecca Greway, Brittany Fikes, Cyrille J Bonhomme, Mark T Esser, Elizabeth J Kelly
Publikováno v:
Clinicaltranslational immunology. 11(4)
Robust, quantitative serology assays are required to accurately measure antibody levels following vaccination and natural infection. We present validation of a quantitative, multiplex, SARS-CoV-2, electrochemiluminescent (ECL) serology assay; show co