Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Kevin M Myles"'
Autor:
Pratima R Chennuri, Josef Zapletal, Raquel D Monfardini, Martial Loth Ndeffo-Mbah, Zach N Adelman, Kevin M Myles
Publikováno v:
PLoS Genetics, Vol 20, Iss 11, p e1011450 (2024)
Here, we demonstrate that single strand annealing (SSA) can be co-opted for the precise autocatalytic excision of a drive element. We have termed this technology Repeat Mediated Excision of a Drive Element (ReMEDE). By engineering direct repeats flan
Externí odkaz:
https://doaj.org/article/cb7a7f2ee10b482ba11c9784c5cda4b3
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 4, p e0009334 (2021)
As a key vector for major arthropod-borne viruses (arboviruses) such as dengue, Zika and chikungunya, control of Aedes aegypti represents a major challenge in public health. Bloodmeal acquisition is necessary for the reproduction of vector mosquitoes
Externí odkaz:
https://doaj.org/article/72b1ac7c8f0048cabc15e76f9c2053f7
Autor:
Josef Zapletal, Himanshu Gupta, Madhav Erraguntla, Zach N Adelman, Kevin M Myles, Mark A Lawley
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217199 (2019)
Mosquito-borne pathogens continue to be a significant burden within human populations, with Aedes aegypti continuing to spread dengue, chikungunya, and Zika virus throughout the world. Using data from a previously conducted study, a linear regression
Externí odkaz:
https://doaj.org/article/ee018d97661e435a982331899b7760ff
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194025 (2018)
The increasing range of Aedes aegypti, vector for Zika, dengue, chikungunya, and other viruses, has brought attention to the need to understand the population and transmission dynamics of this mosquito. It is well understood that environmental factor
Externí odkaz:
https://doaj.org/article/5c08cdc51c434d1c8b69bbc642f8ec37
Autor:
Keun Chae, Bryan Contreras, Joseph S. Romanowski, Chanell Dawson, Kevin M. Myles, Zach N. Adelman
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract While gene drive strategies have been proposed to aid in the control of mosquito-borne diseases, additional genome engineering technologies may be required to establish a defined end-of-product-life timeline. We previously demonstrated that
Externí odkaz:
https://doaj.org/article/bc97b98283914ad4987d0d0f92111d5f
Publikováno v:
PLoS Pathogens, Vol 9, Iss 8, p e1003462 (2013)
Externí odkaz:
https://doaj.org/article/46b45a915a814951adae4f3f7a05f9b3
Autor:
Zach N Adelman, Michelle A E Anderson, Michael R Wiley, Marta G Murreddu, Glady Hazitha Samuel, Elaine M Morazzani, Kevin M Myles
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 5, p e2239 (2013)
The impact of global climate change on the transmission dynamics of infectious diseases is the subject of extensive debate. The transmission of mosquito-borne viral diseases is particularly complex, with climatic variables directly affecting many par
Externí odkaz:
https://doaj.org/article/0e6f528f6f79445eb3e8b32ed01c43b0
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e60082 (2013)
In addition to its role as the primary vector for dengue viruses, Aedes aegypti has a long history as a genetic model organism for other bloodfeeding mosquitoes, due to its ease of colonization, maintenance and reproductive productivity. Though its g
Externí odkaz:
https://doaj.org/article/8f947ec3519b4aafbaef42bbf6a47b8d
Publikováno v:
PLoS Pathogens, Vol 8, Iss 1, p e1002470 (2012)
The natural maintenance cycles of many mosquito-borne pathogens require establishment of persistent non-lethal infections in the invertebrate host. The mechanism by which this occurs is not well understood, but we have previously shown that an antivi
Externí odkaz:
https://doaj.org/article/677cc73d31e24d698d2c1151e32e939f
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e13924 (2010)
Double subgenomic Sindbis virus (dsSINV) vectors are widely used for the expression of proteins, peptides, and RNA sequences. These recombinant RNA viruses permit high level expression of a heterologous sequence in a wide range of animals, tissues, a
Externí odkaz:
https://doaj.org/article/e1b691a6eb4542668cc214778db814e2