Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Kevin M Dean"'
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0268614 (2022)
Deformation measurement is a key process in traction force microscopy (TFM). Conventionally, particle image velocimetry (PIV) or correlation-based particle tracking velocimetry (cPTV) have been used for such a purpose. Using simulated bead images, we
Externí odkaz:
https://doaj.org/article/e197f0c7edec45e5a27c396590f4a34c
Autor:
Sangyoon J Han, Evgenia V Azarova, Austin J Whitewood, Alexia Bachir, Edgar Guttierrez, Alex Groisman, Alan R Horwitz, Benjamin T Goult, Kevin M Dean, Gaudenz Danuser
Publikováno v:
eLife, Vol 10 (2021)
Talin and vinculin are mechanosensitive proteins that are recruited early to integrin-based nascent adhesions (NAs). In two epithelial cell systems with well-delineated NA formation, we find these molecules concurrently recruited to the subclass of N
Externí odkaz:
https://doaj.org/article/6da67ed4c2294cc29a0a867acd5126d3
Autor:
Etai Sapoznik, Bo-Jui Chang, Jaewon Huh, Robert J Ju, Evgenia V Azarova, Theresa Pohlkamp, Erik S Welf, David Broadbent, Alexandre F Carisey, Samantha J Stehbens, Kyung-Min Lee, Arnaldo Marín, Ariella B Hanker, Jens C Schmidt, Carlos L Arteaga, Bin Yang, Yoshihiko Kobayashi, Purushothama Rao Tata, Rory Kruithoff, Konstantin Doubrovinski, Douglas P Shepherd, Alfred Millett-Sikking, Andrew G York, Kevin M Dean, Reto P Fiolka
Publikováno v:
eLife, Vol 9 (2020)
We present an oblique plane microscope (OPM) that uses a bespoke glass-tipped tertiary objective to improve the resolution, field of view, and usability over previous variants. Owing to its high numerical aperture optics, this microscope achieves lat
Externí odkaz:
https://doaj.org/article/2e2ea231dd3f469fb756c32b4e680715
Autor:
Kyung-min Lee, Angel L. Guerrero-Zotano, Alberto Servetto, Dhivya R. Sudhan, Chang-Ching Lin, Luigi Formisano, Valerie M. Jansen, Paula González-Ericsson, Melinda E. Sanders, Thomas P. Stricker, Ganesh Raj, Kevin M. Dean, Reto Fiolka, Lewis C. Cantley, Ariella B. Hanker, Carlos L. Arteaga
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The 17q23 amplicon is associated with poor outcome in ER+ breast cancers, but the causal genes responsible endocrine resistance in this region are unclear. In this study, the authors demonstrate that PRR11 located at 17q23, is critical for conferring
Externí odkaz:
https://doaj.org/article/b05239cf19fd4376936d7400b75ca161
Autor:
Andrew D. Weems, Erik S. Welf, Meghan K. Driscoll, Felix Y. Zhou, Hanieh Mazloom-Farsibaf, Bo-Jui Chang, Vasanth S. Murali, Gabriel M. Gihana, Byron G. Weiss, Joseph Chi, Divya Rajendran, Kevin M. Dean, Reto Fiolka, Gaudenz Danuser
Publikováno v:
Nature. 615:517-525
Autor:
Benjamin A Nanes, Kushal Bhatt, Evgenia Azarova, Divya Rajendran, Tadamoto Isogai, Kevin M Dean, Gaudenz Danuser
Publikováno v:
bioRxiv
Keratin intermediate filaments form strong mechanical scaffolds that confer structural stability to epithelial tissues, but the reason this function requires a protein family with fifty-four isoforms is not understood. During skin wound healing, a sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd368f5450c90bea7d718415c798ad3
https://doi.org/10.1101/2023.05.04.538989
https://doi.org/10.1101/2023.05.04.538989
Autor:
Quinten Patterson, Reto Fiolka, Saumya Vora, Hao Liu, Denise K. Marciano, Kevin M. Dean, Chitkale Hiremath, Andrew R. Jamieson, Michael T. Dellinger, Zhiguo Shang
Publikováno v:
Journal of the American Society of Nephrology. 32:3099-3113
Background Lymphatic abnormalities are observed in several types of kidney disease, but the relationship between the renal lymphatic system and renal function is unclear. The discovery of lymphatic-specific proteins, advances in microscopy, and avail
Discoidin domain receptor 2 regulates aberrant mesenchymal lineage cell fate and matrix organization
Autor:
Chase A. Pagani, Alec C. Bancroft, Robert J. Tower, Nicholas Livingston, Yuxiao Sun, Jonathan Y. Hong, Robert N. Kent, Amy L. Strong, Johanna H. Nunez, Jessica Marie R. Medrano, Nicole Patel, Benjamin A. Nanes, Kevin M. Dean, Zhao Li, Chunxi Ge, Brendon M. Baker, Aaron W. James, Stephen J. Weiss, Renny T. Franceschi, Benjamin Levi
Publikováno v:
Science advances. 8(51)
Extracellular matrix (ECM) interactions regulate both the cell transcriptome and proteome, thereby determining cell fate. Traumatic heterotopic ossification (HO) is a disorder characterized by aberrant mesenchymal lineage (MLin) cell differentiation,
Autor:
Bingying Chen, Bo-Jui Chang, Felix Y. Zhou, Stephan Daetwyler, Etai Sapoznik, Benjamin A Nanes, Isabella Terrazas, Gabriel M. Gihana, Lizbeth Perez Castro, Isaac S. Chan, Maralice Conacci-Sorrell, Kevin M. Dean, Alfred Millett-Sikking, Andrew G. York, Reto Fiolka
Publikováno v:
Biomed Opt Express
Fast volumetric imaging of large fluorescent samples with high-resolution is required for many biological applications. Oblique plane microscopy (OPM) provides high spatiotemporal resolution, but the field of view is typically limited by its optical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9495041972806fd53aa2cd00a52c8c1
https://europepmc.org/articles/PMC9872888/
https://europepmc.org/articles/PMC9872888/