Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Kevin M D'Auria"'
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Akademický článek
Strategies to minimize false positives and interpret novel microdeletions based on maternal copy-number variants in 87,000 noninvasive prenatal screens
Autor: Kristjan Eerik Kaseniit, Gregory J Hogan, Kevin M D’Auria, Carrie Haverty, Dale Muzzey
Publikováno v: BMC Medical Genomics, Vol 11, Iss 1, Pp 1-13 (2018)
Abstract Background Noninvasive prenatal screening (NIPS) of common aneuploidies using cell-free DNA from maternal plasma is part of routine prenatal care and is widely used in both high-risk and low-risk patient populations. High specificity is need
Externí odkaz: https://doaj.org/article/29f1a9ad1aa64382bcd4ecb370351db3
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2
Strategies to minimize false positives and interpret novel microdeletions based on maternal copy-number variants in 87,000 noninvasive prenatal screens
Autor: Gregory J. Hogan, Kristjan Eerik Kaseniit, Dale Muzzey, Carrie Haverty, Kevin M. D'Auria
Publikováno v: BMC Medical Genomics, Vol 11, Iss 1, Pp 1-13 (2018)
BMC Medical Genomics
Background Noninvasive prenatal screening (NIPS) of common aneuploidies using cell-free DNA from maternal plasma is part of routine prenatal care and is widely used in both high-risk and low-risk patient populations. High specificity is needed for cl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e083ed0da386af535315f23790b255
http://link.springer.com/article/10.1186/s12920-018-0410-6
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3
A metabolic network approach for the identification and prioritization of antimicrobial drug targets
Autor: Jason A. Papin, Richard D. Pearson, Kevin M. D'Auria, Arvind K. Chavali, Erik L. Hewlett
Publikováno v: Trends in Microbiology. 20:113-123
For many infectious diseases, novel treatment options are needed in order to address problems with cost, toxicity and resistance to current drugs. Systems biology tools can be used to gain valuable insight into pathogenic processes and aid in expedit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e703346ade36fb98aebca2225a4253
https://doi.org/10.1016/j.tim.2011.12.004
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6
High temporal resolution of glucosyltransferase dependent and independent effects of Clostridium difficile toxins across multiple cell types
Autor: Erik L. Hewlett, Mary C. Gray, Kevin M. D'Auria, Edward J. van Opstal, Meghan J. Bloom, Yesenia Reyes, Jason A. Papin
Publikováno v: BMC Microbiology
Background Clostridium difficile toxins A and B (TcdA and TcdB), considered to be essential for C. difficile infection, affect the morphology of several cell types with different potencies and timing. However, morphological changes over various time
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a02a7e6bbce09a65856a28c0daef48
https://doi.org/10.1186/s12866-015-0361-4
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7
In Vivo Physiological and Transcriptional Profiling Reveals Host Responses to Clostridium difficile Toxin A and Toxin B
Autor: Erik L. Hewlett, Gina M. Donato, Mary C. Gray, Glynis L. Kolling, Cirle A. Warren, Kevin M. D'Auria, Jason A. Papin
Toxin A (TcdA) and toxin B (TcdB) of Clostridium difficile cause gross pathological changes (e.g., inflammation, secretion, and diarrhea) in the infected host, yet the molecular and cellular pathways leading to observed host responses are poorly unde
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f7f8d7844591a86df17d98bf33c230
https://europepmc.org/articles/PMC3811747/
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8
MicroRNAs induced in melanoma treated with combination targeted therapy of Temsirolimus and Bevacizumab
Autor: Amber L. Shada, Craig L. Slingluff, Dandan Sun, Anindya Dutta, Aubrey G Wagenseller, Jason A. Papin, Kevin M. D'Auria, Kerrington R. Molhoek, Cheryl F. Murphy
Publikováno v: Journal of Translational Medicine
Background Targeted therapies directed at commonly overexpressed pathways in melanoma have clinical activity in numerous trials. Little is known about how these therapies influence microRNA (miRNA) expression, particularly with combination regimens.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a26e71d9aead60aef84ee4ad6be19f6
https://doi.org/10.1186/1479-5876-11-218
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9
Structural and Dynamic Determinants of Protein-Peptide Recognition
Autor: Feng Ding, Kevin M. D'Auria, Onur Dagliyan, Elizabeth A. Proctor, Nikolay V. Dokholyan
SummaryProtein-peptide interactions play important roles in many cellular processes, including signal transduction, trafficking, and immune recognition. Protein conformational changes upon binding, an ill-defined peptide binding surface, and the larg
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c79b6d754f7a5c978ca1f48fe0b4fde8
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10
Systems analysis of the transcriptional response of human ileocecal epithelial cells to Clostridium difficile toxins and effects on cell cycle control
Autor: Jason A. Papin, Lauren M Cave, Michael D. Solga, Joanne Lannigan, Glynis L. Kolling, Cirle A. Warren, Erik L. Hewlett, Kevin M. D'Auria, Mary C. Gray, Gina M. Donato
Publikováno v: BMC Systems Biology
BMC Systems Biology, Vol 6, Iss 1, p 2 (2012)
Background Toxins A and B (TcdA and TcdB) are Clostridium difficile's principal virulence factors, yet the pathways by which they lead to inflammation and severe diarrhea remain unclear. Also, the relative role of either toxin during infection and th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a00f6fbbc5d84bd60088f52c9d4ccb76
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