Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Kevin M, Weeks"'
Autor:
Jayashree Kumar, Lela Lackey, Justin M Waldern, Abhishek Dey, Anthony M Mustoe, Kevin M Weeks, David H Mathews, Alain Laederach
Publikováno v:
eLife, Vol 11 (2022)
Splicing is highly regulated and is modulated by numerous factors. Quantitative predictions for how a mutation will affect precursor mRNA (pre-mRNA) structure and downstream function are particularly challenging. Here, we use a novel chemical probing
Externí odkaz:
https://doaj.org/article/7e9b5b2f330645718e814d97ac9b25a0
Publikováno v:
Cell Genomics, Vol 2, Iss 2, Pp 100097- (2022)
Summary: Modifications are present on many classes of RNA, including tRNA, rRNA, and mRNA. These modifications modulate diverse biological processes such as genetic recoding and mRNA export and folding. In addition, modifications can be introduced to
Externí odkaz:
https://doaj.org/article/6e972d1b2f2d40228da93e5753716783
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 12, p e1009632 (2021)
SHAPE-JuMP is a concise strategy for identifying close-in-space interactions in RNA molecules. Nucleotides in close three-dimensional proximity are crosslinked with a bi-reactive reagent that covalently links the 2'-hydroxyl groups of the ribose moie
Externí odkaz:
https://doaj.org/article/c8a006f61d6a475692a933302ef37614
Publikováno v:
Accounts of Chemical Research. 56:763-775
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::202eff11c305acfcbedc6a0cd954f85e
https://doi.org/10.1021/acs.accounts.2c00782
https://doi.org/10.1021/acs.accounts.2c00782
Autor:
Karyn Schmidt, Chase A. Weidmann, Thomas A. Hilimire, Elaine Yee, Breanne M. Hatfield, John S. Schneekloth, Jr., Kevin M. Weeks, Carl D. Novina
Publikováno v:
Cell Reports, Vol 30, Iss 2, Pp 541-554.e5 (2020)
Summary: Long non-coding RNAs (lncRNAs) are critical regulators of numerous physiological processes and diseases, especially cancers. However, development of lncRNA-based therapies is limited because the mechanisms of many lncRNAs are obscure, and in
Externí odkaz:
https://doaj.org/article/9d6be757e5b14c61a203d93299ae6d6f
Autor:
Philip J Grayeski, Chase A Weidmann, Jayashree Kumar, Lela Lackey, Anthony M Mustoe, Steven Busan, Alain Laederach, Kevin M Weeks
Publikováno v:
Nucleic Acids Research. 50:9689-9704
SERPINA1 mRNAs encode the protease inhibitor α-1-antitrypsin and are regulated through post-transcriptional mechanisms. α-1-antitrypsin deficiency leads to chronic obstructive pulmonary disease (COPD) and liver cirrhosis, and specific variants in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb810ff2966ba613603ad6a2c8b20be
https://doi.org/10.1093/nar/gkac739
https://doi.org/10.1093/nar/gkac739
Autor:
J. Winston Arney, Kevin M. Weeks
Publikováno v:
Biochemistry. 61(15)
Structured RNAs bind ligands and are attractive targets for small-molecule drugs. A wide variety of analytical methods have been used to characterize RNA-ligand interactions, but our experience is that most have significant limitations in terms of ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c2eb253ccfef1460df357d798fd6774
https://pubmed.ncbi.nlm.nih.gov/35802500
https://pubmed.ncbi.nlm.nih.gov/35802500
Publikováno v:
PLoS Biology, Vol 17, Iss 9, p e3000393 (2019)
The ribosome moves between distinct structural states and is organized into multiple functional domains. Here, we examined hundreds of occurrences of pairwise through-space communication between nucleotides in the ribosome small subunit RNA using RNA
Externí odkaz:
https://doaj.org/article/4e96b1e2e3b44a1cb540cd16cc708185
To survive stress, eukaryotes selectively translate stress-related transcripts while inhibiting growth-associated protein production. How this translational reprogramming occurs under biotic stress has not been systematically studied. To identify com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cda71b55e2c3d24fb866f5361e935b6f
https://doi.org/10.1101/2023.05.09.540021
https://doi.org/10.1101/2023.05.09.540021
Autor:
Patrick S. Irving, Kevin M. Weeks
Chemical probing technologies enable high-throughput examination of diverse structural features of RNA including local nucleotide flexibility, RNA secondary structure, protein- and ligand-binding, through-space interaction networks, and multi-state s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41aacef2c3fd521d80a7be45c88c93b6
https://doi.org/10.1101/2023.04.25.538311
https://doi.org/10.1101/2023.04.25.538311