Zobrazeno 1 - 10
of 422
pro vyhledávání: '"Kevin M, Prise"'
Autor:
Valentina Giacometti, PhD, Owen McLaughlin, MSc, Patrick Comiskey, MSc, Hannah Marshall, MSc, Orla A. Houlihan, MB, BCh, BAO, Glenn Whitten, MSc, Kevin M. Prise, PhD, Alan R. Hounsell, PhD, Suneil Jain, MB, BCh, BAO, PhD, Conor K. McGarry, PhD
Publikováno v:
Advances in Radiation Oncology, Vol 9, Iss 3, Pp 101396- (2024)
Purpose: To evaluate the quality of the interspace between the prostate and rectum and assess the effect on the dose to the rectum by measuring the spacer quality score (SQS) before and after implanting a hydrogel rectal spacer. Methods and Materials
Externí odkaz:
https://doaj.org/article/95281abd405647738c50df6fdc9f9f11
Autor:
Victoria L. Dunne, Mihaela Ghita-Pettigrew, Kelly M. Redmond, Donna M. Small, Sinéad Weldon, Clifford C. Taggart, Kevin M. Prise, Gerard G. Hanna, Karl T. Butterworth
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7817 (2024)
Radiotherapy (RT) treatment is an important strategy for the management of non-small cell lung cancer (NSCLC). Local recurrence amongst patients with late-stage NSCLC remains a challenge. The loss of PTEN has been associated with radio-resistance. Th
Externí odkaz:
https://doaj.org/article/de5ce7bcfa6e4ebabbff9e5742305a17
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract There is agreement that high-LET radiation has a high Relative Biological Effectiveness (RBE) when delivered as a single treatment, but how it interacts with radiations of different qualities, such as X-rays, is less clear. We sought to clar
Externí odkaz:
https://doaj.org/article/a890c2850e504ea6a271d71550f9f850
Publikováno v:
F1000Research, Vol 12 (2023)
Background: Preclinical models of radiotherapy (RT) response are vital for the continued success and evolution of RT in the treatment of cancer. The irradiation of tissues in mouse models necessitates high levels of precision and accuracy to recapitu
Externí odkaz:
https://doaj.org/article/ac648bc3ae1f4b7d8bb5639824430be6
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 7, Pp 2982-3000 (2022)
Adult brain tumors (glioma) represent a cancer of unmet need where standard-of-care is non-curative; thus, new therapies are urgently needed. It is unclear whether isocitrate dehydrogenases (IDH1/2) when not mutated have any role in gliomagenesis or
Externí odkaz:
https://doaj.org/article/2794f1d317b5410bbd896c42586ecb0d
Autor:
Kathryn H. Brown, Mihaela Ghita, Ludwig J. Dubois, Dirk de Ruysscher, Kevin M. Prise, Frank Verhaegen, Karl T. Butterworth
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 34, Iss , Pp 112-119 (2022)
Background and purpose: To provide a scoping review of published studies using small animal irradiators and highlight the progress in preclinical radiotherapy (RT) studies enabled by these platforms since their development and commercialization in 20
Externí odkaz:
https://doaj.org/article/9b553f704e0a43eca840dbfeabb33a5b
Autor:
Kathryn H. Brown, Neree Payan, Sarah Osman, Mihaela Ghita, Gerard M. Walls, Ileana Silvestre Patallo, Giuseppe Schettino, Kevin M. Prise, Conor K. McGarry, Karl T. Butterworth
Publikováno v:
Physics and Imaging in Radiation Oncology, Vol 26, Iss , Pp 100446- (2023)
Background and purpose: Radiomics features derived from medical images have the potential to act as imaging biomarkers to improve diagnosis and predict treatment response in oncology. However, the complex relationships between radiomics features and
Externí odkaz:
https://doaj.org/article/dcb75e9279f44e33b7760041a0cbec07
Autor:
Pankaj Chaudhary, Deborah C. Gwynne, Boris Odlozilik, Aaron McMurray, Giuliana Milluzzo, Carla Maiorino, Domenico Doria, Hamad Ahmed, Lorenzo Romagnani, Aaron Alejo, Hersimerjit Padda, James Green, David Carroll, Nicola Booth, Paul McKenna, Satyabrata Kar, Giada Petringa, Roberto Catalano, Francesco P. Cammarata, Giuseppe A. P. Cirrone, Stephen J. McMahon, Kevin M. Prise, Marco Borghesi
Publikováno v:
Radiation Oncology, Vol 17, Iss 1, Pp 1-14 (2022)
Abstract Background There is currently significant interest in assessing the role of oxygen in the radiobiological effects at ultra-high dose rates. Oxygen modulation is postulated to play a role in the enhanced sparing effect observed in FLASH radio
Externí odkaz:
https://doaj.org/article/c922634e63314088a19183d22aca3a4f
Autor:
Sarah O. S. Osman, Ciaran Fairmichael, Glenn Whitten, Gavin S. Lundy, Rachel Wesselman, Melissa LaBonte Wilson, Alan R. Hounsell, Kevin M. Prise, Denise Irvine, Conor K. McGarry, Suneil Jain
Publikováno v:
Radiation Oncology, Vol 17, Iss 1, Pp 1-10 (2022)
Abstract Purpose Boosting dominant intra-prostatic lesions (DILs) has the potential to increase the therapeutic ratio in prostate cancer radiotherapy. In this study, employing 5-fraction stereotactic ablative radiotherapy (SABR) volumetric modulated
Externí odkaz:
https://doaj.org/article/11192b03d9494a15b23e8a2a8018700c
Autor:
James P. Beirne, Alan Gilmore, Caitríona E. McInerney, Aideen Roddy, W. Glenn McCluggage, Ian J.G. Harley, M. Abdullah Alvi, Kevin M. Prise, Darragh G. McArt, Paul B. Mullan
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 3359-3371 (2022)
Introduction: Cancers presenting at advanced stages inherently have poor prognosis. High grade serous carcinoma (HGSC) is the most common and aggressive form of tubo-ovarian cancer. Clinical tests to accurately diagnose and monitor this condition are
Externí odkaz:
https://doaj.org/article/1c8bf9d25c064531ac26941f78c36845