Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction

Autor: Keith Siew, Kevin A. Nestler, Charlotte Nelson, Viola D’Ambrosio, Chutong Zhong, Zhongwang Li, Alessandra Grillo, Elizabeth R. Wan, Vaksha Patel, Eliah Overbey, JangKeun Kim, Sanghee Yun, Michael B. Vaughan, Chris Cheshire, Laura Cubitt, Jessica Broni-Tabi, Maneera Yousef Al-Jaber, Valery Boyko, Cem Meydan, Peter Barker, Shehbeel Arif, Fatemeh Afsari, Noah Allen, Mohammed Al-Maadheed, Selin Altinok, Nourdine Bah, Samuel Border, Amanda L. Brown, Keith Burling, Margareth Cheng-Campbell, Lorianna M. Colón, Lovorka Degoricija, Nichola Figg, Rebecca Finch, Jonathan Foox, Pouya Faridi, Alison French, Samrawit Gebre, Peter Gordon, Nadia Houerbi, Hossein Valipour Kahrood, Frederico C. Kiffer, Aleksandra S. Klosinska, Angela Kubik, Han-Chung Lee, Yinghui Li, Nicholas Lucarelli, Anthony L. Marullo, Irina Matei, Colleen M. McCann, Sayat Mimar, Ahmed Naglah, Jérôme Nicod, Kevin M. O’Shaughnessy, Lorraine Christine De Oliveira, Leah Oswalt, Laura Ioana Patras, San-huei Lai Polo, María Rodríguez-Lopez, Candice Roufosse, Omid Sadeghi-Alavijeh, Rebekah Sanchez-Hodge, Anindya S. Paul, Ralf Bernd Schittenhelm, Annalise Schweickart, Ryan T. Scott, Terry Chin Choy Lim Kam Sian, Willian A. da Silveira, Hubert Slawinski, Daniel Snell, Julio Sosa, Amanda M. Saravia-Butler, Marshall Tabetah, Erwin Tanuwidjaya, Simon Walker-Samuel, Xiaoping Yang, Yasmin, Haijian Zhang, Jasminka Godovac-Zimmermann, Pinaki Sarder, Lauren M. Sanders, Sylvain V. Costes, Robert A. A. Campbell, Fathi Karouia, Vidya Mohamed-Alis, Samuel Rodriques, Steven Lynham, Joel Ricky Steele, Sergio Baranzini, Hossein Fazelinia, Zhongquan Dai, Akira Uruno, Dai Shiba, Masayuki Yamamoto, Eduardo A.C.Almeida, Elizabeth Blaber, Jonathan C. Schisler, Amelia J. Eisch, Masafumi Muratani, Sara R. Zwart, Scott M. Smith, Jonathan M. Galazka, Christopher E. Mason, Afshin Beheshti, Stephen B. Walsh

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Abstract Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored

Externí odkaz: https://doaj.org/article/314b862fbe6c4c54a23cb008317e48c9

Modified HEK cells simulate DCT cells in their sensitivity and response to changes in extracellular K

Autor: Meena Murthy, Kevin M. O’Shaughnessy

Publikováno v: Physiological Reports, Vol 7, Iss 22, Pp n/a-n/a (2019)

Abstract A potassium (K+) rich diet is known to have an antihypertensive effect that has been embodied by the NHLBI in the DASH diet. However, the molecular basis for this blood pressure‐lowering effect has been unclear, until a recent study propos

Externí odkaz: https://doaj.org/article/b1a55acad00546659d8fc82cf2e2e751

β1-Adrenoreceptor Polymorphisms and Blood Pressure: 49S Variant Increases Plasma Renin But Not Blood Pressure in Hypertensive Patients

Autor: Alastair J Sandilands, Kevin M O’Shaughnessy, null Yasmin

Publikováno v: American Journal of Hypertension

BACKGROUND Activation of beta-1 adrenoreceptor (β1-AR) in the kidney releases renin that plays a major role in the maintenance of blood pressure. Genetic variation in β1-AR could therefore alter the physiological and clinical effects of this hormon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e099e24ea940f6fb612af8599f35acd
https://doi.org/10.1093/ajh/hpz019

Modified HEK cells simulate DCT cells in their sensitivity and response to changes in extracellular K

Autor: Kevin M. O'Shaughnessy, Meena Murthy

Publikováno v: Physiological Reports
Physiological Reports, Vol 7, Iss 22, Pp n/a-n/a (2019)

A potassium (K+) rich diet is known to have an antihypertensive effect that has been embodied by the NHLBI in the DASH diet. However, the molecular basis for this blood pressure‐lowering effect has been unclear, until a recent study proposed a mode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c405720c98f174e4a5cbc9216ac7c1ea
https://pubmed.ncbi.nlm.nih.gov/31762176

Novel Insertion Mutation in KCNJ5 Channel Produces Constitutive Aldosterone Release From H295R Cells

Autor: Ruth D. Murrell-Lagnado, Andrew J. Thompson, Kevin M. O'Shaughnessy, Richard D. Gordon, Nichola Figg, Iris Hardege, Michael Stowasser, Shengxin Xu

Publikováno v: Molecular Endocrinology. 29:1522-1530

Primary aldosteronism accounts for 5%-10% of hypertension and in a third of cases is caused by autonomous aldosterone production by adenomas (APA). Somatic mutations in the potassium channel encoded by KCNJ5 have been detected in surgically removed A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6244b7676ec52aa5d6b63fbd8a9568e
https://doi.org/10.1210/me.2015-1195