Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kevin M, Manz"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
The nucleus accumbens (NAc) guides reward-related motivated behavior implicated in pathological behavioral states, including addiction and depression. These behaviors depend on the precise neuromodulatory actions of Gi/o-coupled G-protein-coupled rec
Externí odkaz:
https://doaj.org/article/e89aa25bf4924d6aaa513aa36223badc
Publikováno v:
Biol Psychiatry
BACKGROUND: Central histamine (HA) signaling modulates diverse cortical and subcortical circuits throughout the brain, including the nucleus accumbens (NAc). The NAc, a key striatal subregion directing reward-related behavior, expresses diverse HA re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f35ffea7f6fc25f643cf056c1f8706
https://doi.org/10.1016/j.biopsych.2021.10.004
https://doi.org/10.1016/j.biopsych.2021.10.004
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100442- (2021)
Summary: Patch-clamp and multi-electrode array electrophysiology techniques are used to measure dynamic functional properties of neurons. Whole-cell and cell-attached patch-clamp recordings in brain slices can be performed in voltage-clamp and curren
Externí odkaz:
https://doaj.org/article/878d5794cf604fb8be17c2590d2b688a
Autor:
Kevin M. Manz, Dipanwita Ghose, Brandon D. Turner, Anne Taylor, Jennifer Becker, Carrie A. Grueter, Brad A. Grueter
Publikováno v:
Cell Reports, Vol 32, Iss 4, Pp 107971- (2020)
Summary: Synaptic plasticity is a key mechanism of learning and memory. Synaptic plasticity mechanisms within the nucleus accumbens (NAc) mediate differential behavioral adaptations. Feedforward inhibition in the NAc occurs when glutamatergic afferen
Externí odkaz:
https://doaj.org/article/64696635030d40c0b3a23b64393baae0
Autor:
Kevin M. Manz, Brad A. Grueter, Benjamin C. Coleman, Alexis Jameson, Sachin Patel, Dipanwita Ghose
Publikováno v:
Neuropsychopharmacology
Parvalbumin-expressing fast-spiking interneurons (PV-INs) within feedforward microcircuits in the nucleus accumbens (NAc) coordinate goal-directed motivational behavior. Feedforward inhibition of medium spiny projection neurons (MSNs) is initiated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a49913ba9ccb29fd09a67735031c65
https://doi.org/10.1038/s41386-021-01167-3
https://doi.org/10.1038/s41386-021-01167-3
Autor:
Brad A. Grueter, Kevin M. Manz, Carrie A. Grueter, Brenda C Shields, Benjamin C. Coleman, Michael R. Tadross
Publikováno v:
J Neurosci
The nucleus accumbens shell (NAcSh) receives extensive monoaminergic input from multiple midbrain structures. However, little is known how norepinephrine (NE) modulates NAc circuit dynamics. Using a dynamic electrophysiological approach with optogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b700906a9177b964f3172bcf385b8c8
https://doi.org/10.1523/jneurosci.2420-20.2021
https://doi.org/10.1523/jneurosci.2420-20.2021
Publikováno v:
Biological Psychiatry. 89:588-599
Background Histamine (HA), a wake-promoting monoamine implicated in stress-related arousal states, is synthesized in histidine decarboxylase–expressing hypothalamic neurons of the tuberomammillary nucleus. Histidine decarboxylase–containing varic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb770fffbb50227ad5499b0dcbf1a7fe
https://doi.org/10.1016/j.biopsych.2020.07.023
https://doi.org/10.1016/j.biopsych.2020.07.023
Publikováno v:
Neuropsychopharmacology
The dynorphin/kappa opioid receptor (KOR) system within the nucleus accumbens (NAc) contributes to affective states. Parvalbumin fast-spiking interneurons (PV-FSIs), a key component of feedforward inhibition, participate in integration of excitatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05146f0105cad3d0989ee10b6ff52c39
https://europepmc.org/articles/PMC8581025/
https://europepmc.org/articles/PMC8581025/
Autor:
Jianfeng Liu, Ruyan Wu, Robert Seaman, Kevin M. Manz, Bernard Johnson, Jimmy Vu, Yufei Huang, Yanan Zhang, Alfred J. Robison, Rachael Neve, Brad A. Grueter, David Dietz, Jun-Xu Li
Publikováno v:
Mol Psychiatry
Relapse remains a major challenge to the treatment of cocaine addiction. Recent studies suggested that the trace amine-associated receptor 1 (TAAR1) could be a promising target to treat cocaine addiction and relapse; however, the underlying mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59351c2df5b219e6a78ee969398b1d60
https://pubmed.ncbi.nlm.nih.gov/35079125
https://pubmed.ncbi.nlm.nih.gov/35079125
Autor:
Eric Delpire, Nicholas K. Smith, Brad A. Grueter, Brandon D. Turner, Betty T Chang, Carrie A. Grueter, Kevin M. Manz
Publikováno v:
Psychopharmacology (Berl)
RATIONALE: Cannabinoid type 1 receptors (CB1Rs) are widely expressed within the brain’s reward circuits and are implicated in regulating drug induced behavioral adaptations. Understanding how CB1R signaling in discrete circuits and cell types contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52afcce56526d3a881553a38347be1f9
https://pubmed.ncbi.nlm.nih.gov/33454843
https://pubmed.ncbi.nlm.nih.gov/33454843