Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Kevin M, Belyk"'
Autor:
Andrew J. Neel, Zhuqing Liu, Tamas Benkovics, Lu Wang, Stephan M. Rummelt, Heather C. Johnson, Kevin M. Belyk, Feng Xu, Cheol K. Chung, David J. Lamberto, Ryan D. Cohen, Stephanus Axnanda, Zachary E. X. Dance
Publikováno v:
Organic Process Research & Development. 27:458-469
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::866d0e06779d25226e9cdd62b807ac7b
https://doi.org/10.1021/acs.oprd.2c00395
https://doi.org/10.1021/acs.oprd.2c00395
Autor:
Caitlin R. Lacker, Travis J. DeLano, Emily P. Chen, Jongrock Kong, Kevin M. Belyk, Tiffany Piou, Sarah E. Reisman
Publikováno v:
Journal of the American Chemical Society. 144:20190-20195
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::271f62a198aac6b93fb2c429e32705bb
https://doi.org/10.1021/jacs.2c07917
https://doi.org/10.1021/jacs.2c07917
Autor:
Rebecca T. Ruck, Kevin M. Belyk, Robert P. Sheridan, Bangping Xiang, Katrina W. Lexa, Scott E. Denmark, Edward C. Sherer, Jeremy J. Henle
Publikováno v:
Organic Process Research & Development. 26:670-682
Molecular design benefits from a strong partnership between chemical intuition and machine learning. Given the proliferation of machine learning in the small molecule catalyst space, several ideas ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad944973723865f0f34405151721140a
https://doi.org/10.1021/acs.oprd.1c00155
https://doi.org/10.1021/acs.oprd.1c00155
Autor:
Caitlin R, Lacker, Travis J, DeLano, Emily P, Chen, Jongrock, Kong, Kevin M, Belyk, Tiffany, Piou, Sarah E, Reisman
Publikováno v:
Journal of the American Chemical Society. 144(44)
An asymmetric cross-coupling of α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ab0c725d4ca41124c28e07320821098c
https://pubmed.ncbi.nlm.nih.gov/36288571
https://pubmed.ncbi.nlm.nih.gov/36288571
Autor:
Xiaoxu Qi, Subramanian Jambu, Yining Ji, Kevin M. Belyk, Nihar R. Panigrahi, Paramjit S. Arora, Neil A. Strotman, Tianning Diao
Publikováno v:
Angewandte Chemie International Edition. 61
Radical addition to dehydroalanine (Dha) represents an appealing, modular strategy to access non-canonical peptide analogues for drug discovery. Prior studies on radical addition to the Dha residue of peptides and proteins have demonstrated outstandi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7a452c2dde591b904cca41e0250e85
https://doi.org/10.1002/anie.202213315
https://doi.org/10.1002/anie.202213315
Autor:
Justin Belardi, Lushi Tan, Bangping Xiang, Nobuyoshi Yasuda, Ed Cleator, John S Edwards, Chen Frank, Lisa DiMichele, Kevin M. Belyk, Fabien L. Cabirol, Scott S. Ceglia, Jianguo Yin, Shen-Chun Kuo, Peter R Mullens, Weng Lin Tang, Adrian Goodyear, Guiquan Liu, Zhiguo Jake Song, Robert A. Reamer, Birgit Kosjek, Brian Bishop
Publikováno v:
Organic Process Research & Development. 21:1851-1858
The development of a scalable asymmetric route to a new calcitonin gene-related peptide (CGRP) receptor antagonist is described. The synthesis of the two key fragments was redefined, and the intermediates were accessed through novel chemistry. Chiral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4130076f382fd9dc4295a7c462f7cec4
https://doi.org/10.1021/acs.oprd.7b00293
https://doi.org/10.1021/acs.oprd.7b00293
Autor:
Robert A. Reamer, Jeffrey C. Moore, Stephen P. Keen, Lin Wang, Feng Peng, Billy Chen, Andrew W. Gibson, David R. Lieberman, David Murray, Kevin M. Belyk, Erika M. Milczek, Michael Williams, Ji Qi, Jongrock Kong, Lushi Tan, Mark McLaughlin, Zhiguo J. Song
Publikováno v:
Organic Letters. 19:926-929
An enantioselective synthesis of the potent anti-HIV nucleoside EFdA is presented. Key features of stereocontrol include construction of the fully substituted 4'-carbon via a biocatalytic desymmetrization of 2-hydroxy-2-((triisopropylsilyl)ethynyl)pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e08712d40da238e75392804655ffca0
https://doi.org/10.1021/acs.orglett.7b00091
https://doi.org/10.1021/acs.orglett.7b00091
Autor:
Hongming Li, R. Thomas Williamson, Edward C. Sherer, Andrew Brunskill, Kevin M. Belyk, Ian W. Davies, Louis-Charles Campeau, Rebecca T. Ruck, Katrina W. Lexa, Sumei Ren, Jingjun Yin, Qinghao Chen, Yining Ji, Alan M. Hyde
Publikováno v:
Chemical Science. 8:2841-2851
Significant catalyst loading reduction and increased reaction robustness have been achieved for a Pd-catalyzed asymmetric intramolecular C–N coupling through comprehensive mechanistic studies. Detailed kinetic, spectroscopic, and crystallographic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70664c499ed1302c88c07ecc44a28965
https://doi.org/10.1039/c6sc05472b
https://doi.org/10.1039/c6sc05472b
Autor:
Danny Gauvreau, Guoyue Zhou, Chaozhan Gu, Louis-Charles Campeau, Wei Zhang, Qinghao Chen, Mélina Girardin, Lushi Tan, Kevin M. Belyk, Peter E. Maligres, Paul D. O’Shea
Publikováno v:
Organic Process Research & Development. 20:1476-1481
Doravirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) currently in phase III clinical trials for the treatment of HIV infection. Herein we describe a robust kilo-scale synthesis for its manufacture. The structure and origin of major im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a5d26d857919165765a72053de41eb3
https://doi.org/10.1021/acs.oprd.6b00163
https://doi.org/10.1021/acs.oprd.6b00163
Autor:
Michael Shevlin, Melodie Christensen, Bangping Xiang, Michael R. Luzung, David M. Tschaen, Teresa Andreani, Stephen M. Dalby, Guy R. Humphrey, Zhiguo Jake Song, Kevin M. Belyk
Publikováno v:
Organic Process Research & Development. 20:1097-1103
The development of a concise asymmetric synthesis of the antiviral development candidate letermovir is reported, proceeding in >60% yield over a total of seven steps from commercially available materials. Key to the effectiveness of this process is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbb7d845915ca1bcfb4ba89e7076fb2c
https://doi.org/10.1021/acs.oprd.6b00076
https://doi.org/10.1021/acs.oprd.6b00076