Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kevin L. Salyers"'
Autor:
Steven D. Knight, Richard M. Keenan, James J. Foley, Diane Naselsky, Ralph A. Rivero, Kevin L. Salyers, Stephen A. Douglas, Anthony Sapienza, Nambi Aiyar, Ming An, Jian Jin, Dashyant Dhanak, Henry M. Sarau
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3950-3954
SAR exploration of the central diamine, benzyl, and terminal aminoalkoxy regions of the N-cyclic azaalkyl benzamide series led to the identification of very potent human urotensin-II receptor antagonists such as 1a with a Ki of 4 nM. The synthesis an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4dd1b85ce899cd065d7316d03d052bf
https://doi.org/10.1016/j.bmcl.2008.06.019
https://doi.org/10.1016/j.bmcl.2008.06.019
Autor:
Kevin L. Salyers, James Samanen, R. Curtis Haltiwanger, M.W. Lark, Leonard M. Azzarano, Irene N. Uzinskas, Karl F. Erhard, Robert N. Willette, Kyung O. Johanson, Catherine J. Gress, Stephen T Ross, Tian Li Yue, Keith W. Ward, William F. Huffman, Russell D. Cousins, Dirk A. Heerding, David J. Rieman, Shing Mei Hwang, Chet Kwon, Brian R. Smith, Ian E. James, William H. Miller, Catherine C.K. Yuan, Dennis T. Takata, Manley Peter J
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1483-1486
In our continuing efforts to identify small molecule vitronectin receptor antagonists, we have discovered a series of phenylbutyrate derivatives, exemplified by 16, which have good potency and excellent oral bioavailability (approximately 100% in rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b020a8d8d76827308cf4beb670e93f46
https://doi.org/10.1016/s0960-894x(03)00102-1
https://doi.org/10.1016/s0960-894x(03)00102-1
Autor:
William H. Miller, Catherine C.K. Yuan, Kalindi Vaidya, Brian J. Polizzi, Dennis T. Takata, Rebecca Claire Greenwood, Dirk A. Heerding, Mark A. Seefeld, Scott B. Winram, Valerie Berry, Martha S. Head, Walter J. Burgess, Andrew P. Fosberry, Nicola G. Wallis, David J. Payne, Stephen Rittenhouse, William F. Huffman, Paul M. Keller, Kevin L. Salyers, Manley Peter J, Kenneth A. Newlander, Deborah Dee Jaworski, Courtney Slater-Radosti, Cheryl A. Janson, Walter E. DeWolf, Irene N. Uzinskas, John Brosky, Stewart C. Pearson, Xiayang Qiu, Emile Chen, Terrance D. Moore, Martin G. Smyth
Publikováno v:
Antimicrobial Agents and Chemotherapy. 46:3118-3124
Bacterial enoyl-acyl carrier protein (ACP) reductase (FabI) catalyzes the final step in each elongation cycle of bacterial fatty acid biosynthesis and is an attractive target for the development of new antibacterial agents. High-throughput screening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997a68e3d46cb5b0dd9196003827969e
https://doi.org/10.1128/aac.46.10.3118-3124.2002
https://doi.org/10.1128/aac.46.10.3118-3124.2002
Autor:
J A Morgan, Kevin L. Salyers, M. A. Levy, Keith W. Ward, Brian R. Smith, J E McSurdy-Freed, Theresa J. Roethke, J. W. Proksch, Leonard M. Azzarano
Publikováno v:
Xenobiotica. 32:221-233
1. SB-242235 (1-(4-piperidinyl)-4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl) imidazole) is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases such as autoimmune or inflammatory diseases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d378a6fd64664acfd7d852a9eef0e083
https://doi.org/10.1080/00498250110100720
https://doi.org/10.1080/00498250110100720
Autor:
Kevin L. Salyers, Leonard M. Azzarano, Keith W. Ward, Brian R. Smith, Mark A. Levy, Tina M. Molnar, Joel W. Proksch, Jeanelle E. McSurdy-Freed
Publikováno v:
Pharmaceutical Research. 18:1336-1344
Purpose. A series of studies was conducted to evaluate the preclinical pharmacokinetics of SB-239063 (trans-1-(4-hydroxycyclohexyl) -4- (4-fluorophenyl) -5- [(2-methoxy) pyrimidin-4-yl] imidazole), a potent and selective p38 MAP kinase inhibitor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c04fdeec11b3b56de755e8d741448db
https://doi.org/10.1023/a:1013002414678
https://doi.org/10.1023/a:1013002414678
Autor:
Irene N. Uzinskas, Kyung O. Johanson, William F. Huffman, R. D. Cousins, William E. Bondinell, Stephen T. Ross, M.W. Lark, Keith W. Ward, Chuan-Kui Yuan, Kevin L. Salyers, Dirk A. Heerding, S M Hwang, Joseph W. Venslavsky, J. Samanen, Karl F. Erhard, Raul R. Calvo, M. Gowen, Pradip K. Bhatnagar, James F. Callahan, Manley Peter J, Doreen Alberts, Brian R. Smith, Kenneth A. Newlander, W.H. Miller, R. C. Haltiwanger, Richard M. Keenan, George B. Stroup, David J. Rieman, Chet Kwon, Leonard M. Azzarano, Ian E. James
Publikováno v:
Journal of Medicinal Chemistry. 43:22-26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::921ed25c145b5edbd1b8a614916fc7cc
https://doi.org/10.1021/jm990446u
https://doi.org/10.1021/jm990446u
Autor:
David J. Rieman, William F. Huffaman, Kevin L. Salyers, Richard M. Keenan, Michael W. Lark, Janice A. Vasko-Moser, Thomas W. Ku, Maxine Gowen, Leonard M. Azzarano, Karl F. Erhard, Stephen T. Ross, Denise Zembryki, Bradbeer Jeremy N, Bondinell William E, Shing-Mei Hwang, William H. Miller, Kenneth A. Newlander, George B. Stroup, Beata Lechowska, Fred H. Drake, Keith W. Ward, Kyung O. Johanson, Brian R. Smith, Paula C. Adams, Ian E. James, R. Curtis Haltiwanger, Russell D. Cousins, Dalia R. Jakas, Sandra J. Hoffman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1807-1812
A new series of potent nonpeptide vitronectin receptor antagonists, based on a novel carbocyclic Gly-Asp mimetic, has been discovered. A representative of this series, SB 265123 (4), has 100% oral bioavailability in rats, and is orally active in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49bebe15e69e0b6c6398f79a6e04504c
https://doi.org/10.1016/s0960-894x(99)00283-8
https://doi.org/10.1016/s0960-894x(99)00283-8
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1152:328-334
Retinoyl β- d -glucuronide is a biologically active metabolite of retinoic acid. The kinetics of UDP-glucuronosyltransferase-catalyzed biosynthesis of retinoyl β- d -glucuronide was examined in rat liver and intestinal native microsomes incubated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf314ea10abf484fb7507a7e8697bae7
https://doi.org/10.1016/0005-2736(93)90265-2
https://doi.org/10.1016/0005-2736(93)90265-2
Autor:
James J. Foley, Brent W. Mccleland, Miriam Burman, Roderick S. Davis, Gary J. Stelman, Martin Rogers, Palovich Michael R, Michelle L. Werner, Keith W. Ward, Jakob Busch-Petersen, Kevin L. Salyers, Theresa J. Roethke, Dulcie B. Schmidt, Leonard M. Azzarano, Henry M. Sarau, Widdowson Katherine L, Peter D. Gorycki
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(6)
N,N'-diarylsquaramides were prepared and evaluated as antagonists of CXCR2. The compounds were found to be potent and selective antagonists of CXCR2. Significant differences in SAR was observed relative to the previously described N,N'-diarylurea ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd7a2d57ef623074395364e347a7faf
https://pubmed.ncbi.nlm.nih.gov/17236763
https://pubmed.ncbi.nlm.nih.gov/17236763
Autor:
Michael W. Lark, Ted Tomaszek, Kevin L. Salyers, David G. Tew, Chao-Pin Lee, Michael S. McQueney, George B. Stroup, Ian E. James, Antonia Marzulli, Hye-Ja Oh, Mark Alan Levy, Dennis S. Yamashita, Maxine Gowen, Brian R. Smith, Daniel F. Veber, Phil Smith
Publikováno v:
Peptides for the New Millennium ISBN: 0792364457
Daniel F. Veber, Dennis S. Yamashita, Hye-Ja Oh, Brian R. Smith, Kevin Salyers, Mark Levy, Chao-Pin Lee, Antonia Marzulli, Phil Smith, Ted Tomaszek, David Tew, Michael McQueney, George B. Stroup, Michael W. Lark, Ian E. James, and Maxine Gowen 6 Depa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57f135c67244f1772e71429a14ebd70d
https://doi.org/10.1007/0-306-46881-6_180
https://doi.org/10.1007/0-306-46881-6_180
