Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Kevin L. Keys"'
Autor:
Yale Jiang, Erick Forno, Yueh-Ying Han, Zhongli Xu, Donglei Hu, Nadia Boutaoui, Celeste Eng, Edna Acosta-Pérez, Scott Huntsman, Angel Colón-Semidey, Kevin L. Keys, José R. Rodríguez-Santana, María Alvarez, Maria Pino-Yanes, Glorisa Canino, Wei Chen, Esteban G. Burchard, Juan C. Celedón
Publikováno v:
Epigenetics, Vol 16, Iss 5, Pp 577-585 (2021)
Latinos are heavily affected with childhood asthma. Little is known about epigenetic mechanisms of asthma in Latino youth. We conducted a meta-analysis of two epigenome-wide association studies (EWAS) of asthma, using DNA from white blood cells (WBCs
Externí odkaz:
https://doaj.org/article/cf590e9b7397474d90b1a02e04c96e6c
Autor:
Linda Kachuri, Angel C. Y. Mak, Donglei Hu, Celeste Eng, Scott Huntsman, Jennifer R. Elhawary, Namrata Gupta, Stacey Gabriel, Shujie Xiao, Kevin L. Keys, Akinyemi Oni-Orisan, José R. Rodríguez-Santana, Michael A. LeNoir, Luisa N. Borrell, Noah A. Zaitlen, L. Keoki Williams, Christopher R. Gignoux, Esteban González Burchard, Elad Ziv
Publikováno v:
Nature Genetics.
We explored the role of genetic ancestry in shaping the genetic architecture of whole blood gene expression using whole genome and RNA sequencing data from 2,733 African American and Hispanic/Latino children. We find that heritability of gene express
Autor:
David J. Erle, Walter L. Eckalbar, Max A. Seibold, Celeste Eng, Jose R. Rodriguez-Santana, Scott Huntsman, Esteban G. Burchard, Marquitta J. White, Cydney Urbanek, Luke R. Bonser, Kevin L. Keys, Eunice Y. Lee, Donglei Hu, Satria Sajuthi, Angel C.Y. Mak, Hyun Min Kang, Gonçalo R. Abecasis, Michael C. Zody, Deborah A. Nickerson, Soren Germer, Deepti Jain, Elad Ziv
Publikováno v:
American journal of respiratory and critical care medicine, vol 202, iss 7
Rationale: Puerto Ricans have the highest childhood asthma prevalence in the United States (23.6%); however, the etiology is uncertain.Objectives: In this study, we sought to uncover the genetic architecture of lung function in Puerto Rican youth wit
Autor:
Esteban G. Burchard, Yueh-Ying Han, Donglei Hu, Erick Forno, Scott Huntsman, Celeste Eng, Maria Pino-Yanes, Glorisa Canino, Yale Jiang, Nadia Boutaoui, Kevin L. Keys, Jose R. Rodriguez-Santana, Edna Acosta-Pérez, María Alvarez, Angel Colón-Semidey, Wei Chen, Zhongli Xu, Juan C. Celedón
Publikováno v:
Epigenetics
Latinos are heavily affected with childhood asthma. Little is known about epigenetic mechanisms of asthma in Latino youth. We conducted a meta-analysis of two epigenome-wide association studies (EWAS) of asthma, using DNA from white blood cells (WBCs
Autor:
Max A. Seibold, Sandra Salazar, Zhanghua Chen, Soren Germer, Satria Sajuthi, Deepti Jain, Frank D. Gilliland, B. Saef, Jaehyun Joo, Esteban G. Burchard, Lara Heermans Winterkorn, Hakon Hakonarson, Marquitta J. White, Gonçalo R. Abecasis, Catherine Reeves, Ann Chen Wu, Shujie Xiao, Deborah A. Nickerson, Fred Lurmann, Scott Huntsman, Michael C. Zody, Patrick M. A. Sleiman, Celeste Eng, L. Keoki Williams, Kevin L. Keys, Eunice Y. Lee, Sam S. Oh, Hongsheng Gui, Angel C.Y. Mak, Donglei Hu, Hyun Min Kang, Rajesh Kumar, Elad Ziv, Blanca E. Himes, Fernando D. Martinez
Publikováno v:
Genetics
Genetics, vol 215, iss 3
Genetics, vol 215, iss 3
Baseline lung function is a standard diagnostic criterion used by clinicians to detect lung diseases. It is a complex trait significantly influenced by both genetics and environmental factors...
Baseline lung function, quantified as forced expir
Baseline lung function, quantified as forced expir
Autor:
Esther Herrera-Luis, Annie Li, Angel C. Y. Mak, Javier Perez-Garcia, Jennifer R. Elhawary, Sam S. Oh, Donglei Hu, Celeste Eng, Kevin L. Keys, Scott Huntsman, Kenneth B. Beckman, Luisa N. Borrell, Jose Rodriguez-Santana, Esteban G. Burchard, Maria Pino-Yanes
Publikováno v:
Clinical Epigenetics
Clinical epigenetics, vol 14, iss 1
Clinical epigenetics, vol 14, iss 1
Introduction DNA methylation studies have associated methylation levels at different CpG sites or genomic regions with lung function. Moreover, genetic ancestry has been associated with lung function in Latinos. However, no epigenome-wide association
Autor:
Luisa N. Borrel, Esther Herrera-Luis, Angel C.Y. Mak, Maria Pino-Yanes, Kenneth B. Beckman, Fabián Lorenzo-Díaz, Javier Perez-Garcia, Esteban G. Burchard, Donglei Hu, Annie Li, Scott Huntsman, Kevin L. Keys, Celeste Eng
Publikováno v:
Molecular pathology and functional genomics.
Autor:
Max A. Seibold, Namrata Gupta, Esteban G. Burchard, Linda Kachuri, Donglei Hu, Jose R. Rodriguez-Santana, Stacey Gabriel, Sam S. Oh, Angel C.Y. Mak, Michael A. LeNoir, Luisa N. Borrell, Hongsheng Gui, Elad Ziv, Christopher R. Gignoux, Scott Huntsman, Kevin L. Keys, Noah Zaitlen, Jennifer R. Elhawary, Akinyemi Oni-Orisan, Shujie Xiao, Celeste Eng, L. Keoki Williams
We analyzed whole genome and RNA sequencing data from 2,733 African American and Hispanic/Latino children to explore ancestry- and heterozygosity-related differences in the genetic architecture of whole blood gene expression. We found that heritabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7297681aa830c6f9d33e49169c8b6897
https://doi.org/10.1101/2021.08.19.456901
https://doi.org/10.1101/2021.08.19.456901
Autor:
Scott Huntsman, Pagé C. Goddard, Joaquin Magana, Andrew M. Zeiger, Kevin L. Keys, Neeta Thakur, Marquitta J. White, Andreas M. Neophytou, Donglei Hu, Eunice Lee, Jennifer R. Elhawary, Lesly-Anne Samedy-Bates, Ting Hu, Angel C.Y. Mak, Esteban G. Burchard, Oona Risse-Adams, Celeste Eng, Maria G. Contreras
Publikováno v:
Ethn Dis
Ethnicity & disease, vol 31, iss 1
Ethnicity & disease, vol 31, iss 1
Objective: Asthma is the most common chronic disease in children. Short-acting bronchodilator medications are the most commonly prescribed asthma treatment worldwide, regardless of disease severity. Puerto Rican children display the highest asthma
Autor:
Pramod Anugu, Scott T. Weiss, Carlo Sidore, Michael Boehnke, Esteban G. Burchard, Corbin Quick, Solomon K. Musani, Marquitta J. White, Kevin L. Keys, Francesco Cucca, Christian Fuchsberger
Publikováno v:
Genetic epidemiology, vol 44, iss 6
Genetic Epidemiology
Genetic Epidemiology
A key aim for current genome-wide association studies (GWAS) is to interrogate the full spectrum of genetic variation underlying human traits, including rare variants, across populations. Deep whole-genome sequencing is the gold standard to capture t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886dd1e288abca6887900f912a3e3e24
https://escholarship.org/uc/item/309835jj
https://escholarship.org/uc/item/309835jj