Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Kevin L. Farmer"'
1
Heat Shock Protein 70 Is Necessary to Improve Mitochondrial Bioenergetics and Reverse Diabetic Sensory Neuropathy following KU-32 Therapy
Autor: Michael Joseph Urban, Rick T. Dobrowsky, Pan Pan, Brian S. J. Blagg, Jiacheng Ma, Huiping Zhao, Kevin L. Farmer
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 348:281-292
Impaired neuronal mitochondrial bioenergetics contributes to the pathophysiologic progression of diabetic peripheral neuropathy (DPN) and may be a focal point for disease management. We have demonstrated that modulating heat shock protein (Hsp) 90 an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96eb855dfe416ca5395e72ad0b9d731
https://doi.org/10.1124/jpet.113.210435
Zobrazit plný text záznamu
2
The effect of exercise on neuropathic symptoms, nerve function, and cutaneous innervation in people with diabetic peripheral neuropathy
Autor: Neena K. Sharma, Rupali Singh, Patricia M. Kluding, Jason Rucker, Kevin L. Farmer, Stephen Jernigan, Mamatha Pasnoor, Douglas E. Wright
Publikováno v: Journal of Diabetes and its Complications. 26:424-429
Although exercise can significantly reduce the prevalence and severity of diabetic complications, no studies have evaluated the impact of exercise on nerve function in people with diagnosed diabetic peripheral neuropathy (DPN). The purpose of this pi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cbc0b3bdc2417579c3d449e48f357f2
https://doi.org/10.1016/j.jdiacomp.2012.05.007
Zobrazit plný text záznamu
3
Diabetic Peripheral Neuropathy: Should a Chaperone Accompany Our Therapeutic Approach?
Autor: Kevin L. Farmer, Rick T. Dobrowsky, Chengyuan Li
Publikováno v: Pharmacological Reviews. 64:880-900
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes that is associated with axonal atrophy, demyelination, blunted regenerative potential, and loss of peripheral nerve fibers. The development and progression of DPN is due in lar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688393fefb76d128ea115ed8108b0343
https://doi.org/10.1124/pr.111.005314
Zobrazit plný text záznamu
4
KU-32, a Novel Drug for Diabetic Neuropathy, Is Safe for Human Islets and ImprovesIn VitroInsulin Secretion and Viability
Autor: S. Janette Williams, Karthik Ramachandran, Lesya Novikova, Rick T. Dobrowsky, Lisa Stehno-Bittel, Sonia Rawal, Brian S. J. Blagg, Kevin L. Farmer
Publikováno v: Experimental Diabetes Research
Experimental Diabetes Research, Vol 2012 (2012)
KU-32 is a novel, novobiocin-based Hsp90 inhibitor that protects against neuronal glucotoxicity and reverses multiple clinical indices of diabetic peripheral neuropathy in a rodent model. However, any drug with potential for treating diabetic complic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db59fe01d54efd0559f1cf4a9218a26
https://doi.org/10.1155/2012/671673
Zobrazit plný text záznamu
5
Modulating molecular chaperones improves sensory fiber recovery and mitochondrial function in diabetic peripheral neuropathy
Autor: Rick T. Dobrowsky, Michael Joseph Urban, Pan Pan, Kevin L. Farmer, Brian S. J. Blagg, Huiping Zhao
Quantification of intra-epidermal nerve fibers (iENFs) is an important approach to stage diabetic peripheral neuropathy (DPN) and is a promising clinical endpoint for identifying beneficial therapeutics. Mechanistically, diabetes decreases neuronal m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::788a2e472d22d2147c348582801c6af8
https://europepmc.org/articles/PMC3336191/
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje