Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Kevin L Legge"'
Autor:
Christopher E. Lopez, Zeb R. Zacharias, Kathleen A. Ross, Balaji Narasimhan, Thomas J. Waldschmidt, Kevin L. Legge
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-14 (2024)
Abstract Influenza A virus (IAV) causes significant morbidity and mortality worldwide due to seasonal epidemics and periodic pandemics. The antigenic drift/shift of IAV continually gives rise to new strains and subtypes, aiding IAV in circumventing p
Externí odkaz:
https://doaj.org/article/287eb466d055478badd3a682ea9675c4
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40733 (2012)
Protection from influenza A virus (IAV) challenge requires switched, high affinity Abs derived from long-lived memory B cells and plasma cells. These B cell subsets are generated in germinal centers (GCs), hallmark structures of T helper cell-driven
Externí odkaz:
https://doaj.org/article/e98481c67c8a49009163c0ce0ed503fd
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12902 (2010)
Previous studies have demonstrated that DC differentially regulate influenza A virus (IAV)-specific CD8 T cell responses in vivo during high and low dose IAV infections. Furthermore, in vitro infection of DC with IAV at low versus high multiplicities
Externí odkaz:
https://doaj.org/article/7551b6a804114b0c8d801c59620a10eb
Autor:
Kai J. Rogers, Paige T. Richards, Zeb R. Zacharias, Laura L. Stunz, Rahul Vijay, Noah S. Butler, Kevin L. Legge, Gail A. Bishop, Wendy Maury
Publikováno v:
Viruses, Vol 15, Iss 6, p 1353 (2023)
Macrophages are critical in the pathogenesis of a diverse group of viral pathogens, both as targets of infection and for eliciting primary defense mechanisms. Our prior in vitro work identified that CD40 signaling in murine peritoneal macrophages pro
Externí odkaz:
https://doaj.org/article/8c6c1dee7bbf437da582233b4cccd168
Autor:
Angela D. Pack, Patrick V. Schwartzhoff, Zeb R. Zacharias, Daniel Fernandez-Ruiz, William R. Heath, Prajwal Gurung, Kevin L. Legge, Chris J. Janse, Noah S. Butler
Publikováno v:
Cell Reports, Vol 36, Iss 8, Pp 109586- (2021)
Summary: During acute malaria, most individuals mount robust inflammatory responses that limit parasite burden. However, long-lived sterilizing anti-malarial memory responses are not efficiently induced, even following repeated Plasmodium exposures.
Externí odkaz:
https://doaj.org/article/551fd0310a5d474cbf06149feb511e75
Autor:
Maury, Kai J. Rogers, Paige T. Richards, Zeb R. Zacharias, Laura L. Stunz, Rahul Vijay, Noah S. Butler, Kevin L. Legge, Gail A. Bishop, Wendy
Publikováno v:
Viruses; Volume 15; Issue 6; Pages: 1353
Macrophages are critical in the pathogenesis of a diverse group of viral pathogens, both as targets of infection and for eliciting primary defense mechanisms. Our prior in vitro work identified that CD40 signaling in murine peritoneal macrophages pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::a4e854e679d890d5864dc13bdb248db1
Autor:
Tyler K. Ulland, Nidhi Jain, Emma E. Hornick, Eric I. Elliott, Gwendolyn M. Clay, Jeffrey J. Sadler, Kathleen A. M. Mills, Ann M. Janowski, A. Paige Davis Volk, Kai Wang, Kevin L. Legge, Lokesh Gakhar, Mohammed Bourdi, Polly J. Ferguson, Mary E. Wilson, Suzanne L. Cassel, Fayyaz S. Sutterwala
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The role of NLRP12 in immunity to bacterial infection is controversial as varied and contrasting results have been published using C57BL/6 mice. Here the authors shed light on this issue, showing that unlike C57BL/6N mice, C57BL/6J mice have a missen
Externí odkaz:
https://doaj.org/article/383567b1d23c49cca2e3d2f968f86070
Autor:
Kevin L. Legge, Kathleen A. Ross, Kody A Waldstein, Steven M. Varga, Laura M Stephens, Balaji Narasimhan, Jason S. McLellan
Publikováno v:
J Immunol
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection in both young children and in older adults. Despite the morbidity, mortality, and high economic burden caused by RSV worldwide, no licensed vaccine is currently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7872e9c1e111d28c57e6f21e3128f3
https://doi.org/10.4049/jimmunol.2100018
https://doi.org/10.4049/jimmunol.2100018
Autor:
Christopher E Lopez, Kevin L. Legge
Publikováno v:
Vaccines, Vol 8, Iss 434, p 434 (2020)
Vaccines
Vaccines
Influenza virus infections represent a serious public health threat and account for significant morbidity and mortality worldwide due to seasonal epidemics and periodic pandemics. Despite being an important countermeasure to combat influenza virus an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa9d9906938c6cbd80c751b25eea14b
https://www.mdpi.com/2076-393X/8/3/434
https://www.mdpi.com/2076-393X/8/3/434
Autor:
Kevin L. Legge, Zeb R. Zacharias, Fayyaz S. Sutterwala, Mary E. Wilson, Balaji Banoth, Nidhi Jain, Suzanne L. Cassel, Gail A. Bishop, Katherine N. Gibson-Corley, Ann M. Miller, Emma E. Hornick
Publikováno v:
The Journal of Immunology. 200:1188-1197
Exaggerated inflammatory responses during influenza A virus (IAV) infection are typically associated with severe disease. Neutrophils are among the immune cells that can drive this excessive and detrimental inflammation. In moderation, however, neutr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e436b9a6be471b7e67cfebd1c2bb1d1f
https://doi.org/10.4049/jimmunol.1700999
https://doi.org/10.4049/jimmunol.1700999