Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kevin L Law"'
Autor:
Yangwei J. Pu, Everett J. Perkins, William D. Diseroad, David M. Bender, Anne H. Dantzig, Jeffrey A. Peterson, Deyi Zhang, Jingqi Bao, Kevin L. Law, Radhe K. Vaid, Nicholas A. Magnus, David Michael Remick, Mccarthy James R, Gregory A. Stephenson, Susan M. Reutzel-Edens, James J. Starling
Publikováno v:
Journal of Medicinal Chemistry. 52:6958-6961
The design, synthesis, and biological characterization of an orally active prodrug (3) of gemcitabine are described. Additionally, the identification of a novel co-crystal solid form of the compound is presented. Valproate amide 3 is orally bioavaila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6826ce1900e7d8561ae2eb5ee2eacd99
https://doi.org/10.1021/jm901181h
https://doi.org/10.1021/jm901181h
Autor:
Tracy D. Self, Peter Ambrose Lander, Bryan H. Norman, Louis Nickolaus Jungheim, Jeffrey Daniel Cohen, Joseph Michael Gruber, Donald C. Paul, James J. Starling, Julian Stanley Kroin, Linda B. Tabas, Anne H. Dantzig, Daniel C. Williams, Kevin L. Law
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:5526-5530
Structure–activity relationship (SAR) studies on the tricyclic isoxazole series of MRP1 modulators have resulted in the identification of potent and selective inhibitors containing cyclohexyl-based linkers. These studies ultimately identified compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aba6718b48f4849b7ad7923e0d77603d
https://doi.org/10.1016/j.bmcl.2005.08.075
https://doi.org/10.1016/j.bmcl.2005.08.075
Autor:
James P. Sluka, Robert L. Shepard, Kenneth Lee Hauser, Anne H. Dantzig, James J. Starling, Alan David Palkowitz, Bryan H. Norman, Julian Stanley Kroin, Kevin L. Law, Mark A. Winter, Linda B. Tabas
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:3381-3386
The benzothiophene LY329146 reverses the drug resistance phenotype in multidrug resistance protein (MRP1)-overexpressing cells when dosed in combination with MRP1-associated oncolytics doxorubicin and vincristine. Additionally, LY329146 inhibited MRP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9653d2d715754d2b10f1961ec0ad498b
https://doi.org/10.1016/s0960-894x(99)00610-1
https://doi.org/10.1016/s0960-894x(99)00610-1
Autor:
Kevin L. Law, James J. Starling, Damon L. Meyer, Roberto Fagnani, Michael S. Hagan, Stephen D. Mikolajczyk
Publikováno v:
Bioconjugate Chemistry. 7:150-158
The physical and pharmacological properties of proteins can be altered by chemical modification with polymers. Preliminary studies showed that attachment of oxidized dextran to the bacterial protein, beta-lactamase (beta L) effectively reduced in viv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a676856f3a1801fa52d1069640bc7213
https://doi.org/10.1021/bc950088j
https://doi.org/10.1021/bc950088j
Autor:
William J. Ehlhardt, John M. Mastro, Vinod F. Patel, Julie N. Hardin, James J. Starling, Kevin L. Law, Zimmermann John Lyle, Joseph M. Woodland
Publikováno v:
Bioconjugate Chemistry. 7:497-510
LY207702 (1) is a difluorinated purine nucleoside that exhibits impressive antitumor activity in preclinical models. This agent, however, also possesses cardiotoxicity which limits the potential cl...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c056d6da6e0abf05555d895510515f0f
https://doi.org/10.1021/bc960038u
https://doi.org/10.1021/bc960038u
Autor:
Jose Eduardo Lopez, James H Wikel, Mary Margaret Mader, Beth A Hollister, Luisa M Martin Cabrejas, Beverly Teicher, James A Aikins, Enrique Alvarez, Philip A Hipskind, Deborah D Giera, Michael E Richett, Rafael Ferritto, Karen L Lobb, Denis J. McCann, Gregory L Durst, Wesley T White, Alfonso De Dios, Cora Sue Grossman, John E. Reilly, Eileen L Considine, Victoriano Molero, Shih Chuan, Tiechao Li, Ho-Shen Lin, Beatriz Lopez, Zhongping Huang, Philip W Iversen, Yiu-Yin Cheung, Kevin L Law
Publikováno v:
Journal of medicinal chemistry. 47(22)
Two closely related diaryl acylsulfonamides were recently reported as potent antitumor agents against a broad spectrum of human tumor xenografts (colon, lung, breast, ovary, and prostate) in nude mice. Especially intriguing was their activity against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e5736c7618e19c7843e687523b3175
https://pubmed.ncbi.nlm.nih.gov/15481975
https://pubmed.ncbi.nlm.nih.gov/15481975
Autor:
James J. Starling, Donald C. Paul, Anne H. Dantzig, Margaret M. Wagner, Kevin L. Law, Daniel C. Williams, Linda B. Tabas, Bryan H. Norman, Tracy D. Self, Sean P. Hollinshead, Joseph W. Wilson, Joseph Michael Gruber
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(6)
Tricyclic isoxazoles were identified from a screen as a novel class of selective multidrug resistance protein (MRP1) inhibitors. From a screen lead, SAR efforts resulted in the preparation of LY 402913 (9h), which inhibits MRP1 and reverses drug resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8e9669ef01190c90f89d619ecfb5dc
https://pubmed.ncbi.nlm.nih.gov/11958985
https://pubmed.ncbi.nlm.nih.gov/11958985
Autor:
William F. Elmquist, Jin Cao, William J. Ehlhardt, Bryan H. Norman, Anne H. Dantzig, Michael Gregory Bell, Chuan Shih, James J. Starling, Joseph Michael Gruber, Todd M. Baughman, Mark A. Winter, Kevin L. Law, Julian Stanley Kroin, Robert L. Shepard
Publikováno v:
Advances in enzyme regulation. 37
The above data indicate that LY335979 displays the following characteristics of an 'ideal modulator' of Pgp-mediated multidrug resistance: high affinity binding to Pgp, high potency for in vitro reversal of drug resistance, high therapeutic index (ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e1042e4150d8fab86c54d18a1ee4e30
https://pubmed.ncbi.nlm.nih.gov/9381979
https://pubmed.ncbi.nlm.nih.gov/9381979
Autor:
Janice K. Payne, James J. Starling, Hamideh Zarrinmayeh, Stephen D. Mikolajczyk, Kevin L. Law, Timothy Alan Shepherd, Damon L. Meyer, James K. Kling, Louis Nickolaus Jungheim
Publikováno v:
Bioconjugate chemistry. 6(4)
Antibody directed catalysis (ADC), the catalytic conversion of prodrugs to drugs by enzymes localized at disease targets by appropriate monoclonal antibodies, has shown promise in the treatment of cancer in nude mouse xenograft models. We investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d84afe9f793e31dd09d3f2e43647117
https://pubmed.ncbi.nlm.nih.gov/7578364
https://pubmed.ncbi.nlm.nih.gov/7578364
Autor:
David M. Bender, Jingqi Bao, Anne H. Dantzig, William D. Diseroad, Kevin L. Law, Nicholas A. Magnus, Jeffrey A. Peterson, Everett J. Perkins, Yangwei J. Pu, Susan M. Reutzel-Edens, David M. Remick, James J. Starling, Gregory A. Stephenson, Radhe K. Vaid, Deyi Zhang, James R. McCarthy
Publikováno v:
Journal of Medicinal Chemistry; Nov2009, Vol. 52 Issue 22, p6958-6961, 4p