Computational analysis of whole-genome differential allelic expression data in human.

Autor: James R Wagner, Bing Ge, Dmitry Pokholok, Kevin L Gunderson, Tomi Pastinen, Mathieu Blanchette

Publikováno v: PLoS Computational Biology, Vol 6, Iss 7, p e1000849 (2010)

Allelic imbalance (AI) is a phenomenon where the two alleles of a given gene are expressed at different levels in a given cell, either because of epigenetic inactivation of one of the two alleles, or because of genetic variation in regulatory regions

Externí odkaz: https://doaj.org/article/fc16ecc7bf85479592c0e95ffb4646ab

Supplementary Fig 1D from Single Nucleotide Polymorphism–Based Genome-Wide Chromosome Copy Change, Loss of Heterozygosity, and Aneuploidy in Barrett's Esophagus Neoplastic Progression

Autor: Brian J. Reid, Kevin L. Gunderson, Dmitry Pokholok, Daniel A. Peiffer, Jessica Arnaudo, Carlo C. Maley, Patricia L. Blount, Carissa A. Sanchez, Patricia C. Galipeau, Xiaohong Li

Supplementary Fig 1C from Single Nucleotide Polymorphism–Based Genome-Wide Chromosome Copy Change, Loss of Heterozygosity, and Aneuploidy in Barrett's Esophagus Neoplastic Progression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03486f75df0baf85fbf0e54712ed56d4
https://doi.org/10.1158/1940-6207.22523226.v1

Supplementary Table S1 from Deletion at Fragile Sites Is a Common and Early Event in Barrett's Esophagus

Autor: Peter S. Rabinovitch, Kevin L. Gunderson, Brian J. Reid, Carlo C. Maley, Carissa A. Sanchez, Robert Odze, Dimitry Pokholok, Daniel A. Peiffer, Michael T. Barrett, Rumen Kostadinov, Lisa A. Lai

Supplementary Table S1.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54876211c5202922ccccf686548b39bf
https://doi.org/10.1158/1541-7786.22519026

Supplementary Table 2 from Single Nucleotide Polymorphism–Based Genome-Wide Chromosome Copy Change, Loss of Heterozygosity, and Aneuploidy in Barrett's Esophagus Neoplastic Progression

Autor: Brian J. Reid, Kevin L. Gunderson, Dmitry Pokholok, Daniel A. Peiffer, Jessica Arnaudo, Carlo C. Maley, Patricia L. Blount, Carissa A. Sanchez, Patricia C. Galipeau, Xiaohong Li

Supplementary Table 2 from Single Nucleotide Polymorphism–Based Genome-Wide Chromosome Copy Change, Loss of Heterozygosity, and Aneuploidy in Barrett's Esophagus Neoplastic Progression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793c1cfabe02455c54f40dd9d4d9f4d7
https://doi.org/10.1158/1940-6207.22523217.v1

Sequences of 95 human MHC haplotypes reveal extreme coding variation in genes other than highly polymorphic HLA class I and II

Autor: Steven Norberg, Kevin L. Gunderson, Jill A. Hollenbach, Weihua Chang, Peter Parham, Paul Norman, Lisbeth A. Guethlein, Melissa Won, Neda Nemat-Gorgani, Claudia Alicata, Emily E. Wroblewski, Laurent Abi-Rached, Mostafa Ronaghi, Tamsen Dunn, Tobias Mann, Thomas Royce

Publikováno v: Genome Research
Genome Research, Cold Spring Harbor Laboratory Press, 2017, 27 (5), pp.813-823. ⟨10.1101/gr.213538.116⟩
Genome Research, 2017, 27 (5), pp.813-823. ⟨10.1101/gr.213538.116⟩

The most polymorphic part of the human genome, the MHC, encodes over 160 proteins of diverse function. Half of them, including the HLA class I and II genes, are directly involved in immune responses. Consequently, the MHC region strongly associates w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7841edf98dcee156bb6be77c169cf3e3
https://doi.org/10.1101/gr.213538.116