Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Kevin Kupcho"'
Autor:
Byounghoon Hwang, Juliano Alves, Dan Lazar, Nidhi Nath, Laurie Engel, Martha O’Brien, Kevin Hsiao, Kevin Kupcho, Becky Godat, Rod Flemming, Said Goueli, Hicham Zegzouti
Publikováno v:
Methods in Molecular Biology ISBN: 9781071629024
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68828c40ecf7fb401fcb4c7fc1f842e7
https://doi.org/10.1007/978-1-0716-2903-1_15
https://doi.org/10.1007/978-1-0716-2903-1_15
Publikováno v:
Cancer Research. 82:1112-1112
Immunogenic cell death (ICD) is a form of apoptosis that kills susceptible populations of cancer cells while teaching the immune system to attack the remaining resistant cells. Chemotherapeutics which induce ICD elicit their immune response by induci
Autor:
Kevin Kupcho, Andrew L. Niles
Publikováno v:
Methods in Molecular Biology ISBN: 9781071611616
This chapter describes a real-time, bioluminescent apoptosis assay technique, which circumvents the well-documented "timing condundrum" encountered when employing traditional apoptosis detection chemistries after exposures with inducers of unknown po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70c210cfc709cf9e7569c3321e683f75
https://doi.org/10.1007/978-1-0716-1162-3_6
https://doi.org/10.1007/978-1-0716-1162-3_6
Autor:
Dan F Lazar, Kevin Hsiao, Casey Sondgeroth, Julia Gilden, Kevin Kupcho, David Thompson, Martha O’Brien, James Cali
Publikováno v:
The Journal of Immunology. 206:27.25-27.25
Rapid (< 70 min), add-and-read assays for cytokine determination were developed with Lumit™ immunoassay technology. Separate antibodies labeled with complementary SmBiT or LgBiT subunits bind to their shared cytokine target, resulting in proximity-
Autor:
Thomas Machleidt, Wenhui Zhou, Jamison Grailer, Terry L. Riss, James J. Cali, John Shultz, Jim Hartnett, Dan Lazar, Robin Hurst, Andrew L. Niles, Tracy J Worzella, Kevin Kupcho
Publikováno v:
Apoptosis
Apoptosis is an important and necessary cell death program which promotes homeostasis and organismal survival. When dysregulated, however, it can lead to a myriad of pathologies from neurodegenerative diseases to cancer. Apoptosis is therefore the su
Publikováno v:
Cancer Research. 80:1832-1832
Damage-associated molecular patterns (DAMPs) liberated or exposed by dying cells after chemotherapeutic treatment augment innate immune responses and improve clinical outcomes as a result of the immunogenic cell death (ICD) phenotype. Extracellular A
Autor:
David V. Thompson, James J. Cali, Julia Gilden, Dan Lazar, Kevin Kupcho, Martha O'brien, Kevin Hsiao, Casey A. Sondgeroth
Publikováno v:
Cancer Research. 80:5595-5595
Cytokines play a major role in cancer biology as inflammatory and immunomodulatory agents and are frequently measured in cell culture models and other biological samples. Various methods are available for in vitro measurement of cytokines, but they t
Autor:
Sara Tesfazghi, Gabrielle N. Winston-McPherson, Herbert Chen, Ajitha Dammalapati, Renata Jaskula-Sztul, Amrit K. Hundal, Xiao-Min Yu, April D. Harrison, Kevin Kupcho, Jacob Eide, Matthew B. Robers, Casi M. Scheinebeck, Weiping Tang
Publikováno v:
Molecular Cancer Therapeutics. 14:499-512
Notch1-3 are transmembrane receptors that appear to be absent in medullary thyroid cancer (MTC). Previous research has shown that induction of Notch1 has a tumor-suppressor effect in MTC cell lines, but little is known about the biologic consequences
Autor:
Mei Cong, Matthew B. Robers, Monika G. Wood, Kevin Kupcho, Keith V. Wood, James Robert Hartnett, Sergiy Levin, Thomas A. Kirkland, Danette L. Daniels, Carolyn C. Woodroofe, Andrew L. Niles, Melanie Dart, Kristopher Zimmerman, Thomas Machleidt, Chad Zimprich, Rachel Friedman Ohana, Yi-Qiang Cheng, Michael R. Slater
Publikováno v:
Nature Communications
The therapeutic action of drugs is predicated on their physical engagement with cellular targets. Here we describe a broadly applicable method using bioluminescence resonance energy transfer (BRET) to reveal the binding characteristics of a drug with
Autor:
Kevin Kupcho, Andrew L. Niles
Publikováno v:
Genetic Engineering & Biotechnology News. 37:12-13