Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Kevin Kos"'
Autor:
Olga S. Blomberg, Kevin Kos, Lorenzo Spagnuolo, Olga I. Isaeva, Hannah Garner, Max D. Wellenstein, Noor Bakker, Danique E.M. Duits, Kelly Kersten, Sjoerd Klarenbeek, Cheei-Sing Hau, Daphne Kaldenbach, Elisabeth A.M. Raeven, Kim Vrijland, Marleen Kok, Karin E. de Visser
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTThe clinical successes of immune checkpoint blockade (ICB) in advanced cancer patients have recently spurred the clinical implementation of ICB in the neoadjuvant and perioperative setting. However, how neoadjuvant ICB therapy affects the sys
Externí odkaz:
https://doaj.org/article/b656e036ddb5458b8a3bb50ca339a61b
Autor:
Kevin Kos, Camilla Salvagno, Max D. Wellenstein, Muhammad A. Aslam, Denize A. Meijer, Cheei-Sing Hau, Kim Vrijland, Daphne Kaldenbach, Elisabeth A.M. Raeven, Martina Schmittnaegel, Carola H. Ries, Karin E. de Visser
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
While regulatory T cells (Tregs) and macrophages have been recognized as key orchestrators of cancer-associated immunosuppression, their cellular crosstalk within tumors has been poorly characterized. Here, using spontaneous models for breast cancer,
Externí odkaz:
https://doaj.org/article/6e040c8634824418819d91cace555fe4
Autor:
Wietske Pieters, Floor Hugenholtz, Kevin Kos, Maxime Cammeraat, Teddy C. Moliej, Daphne Kaldenbach, Sjoerd Klarenbeek, Mark Davids, Lisa Drost, Charlotte de Konink, Elly Delzenne-Goette, Karin E. de Visser, Hein te Riele
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
The gut microbiota strongly impacts the development of sporadic colorectal cancer (CRC), but it is largely unknown how the microbiota affects the pathogenesis of mismatch-repair-deficient CRC in the context of Lynch syndrome. In a mouse model for Lyn
Externí odkaz:
https://doaj.org/article/ea7cde7a89e14a07858878eb822c53b1
Autor:
Eva M. Putz, Camille Guillerey, Kevin Kos, Kimberley Stannard, Kim Miles, Rebecca B. Delconte, Kazuyoshi Takeda, Sandra E. Nicholson, Nicholas D. Huntington, Mark J. Smyth
Publikováno v:
OncoImmunology, Vol 6, Iss 2 (2017)
The cytokine-induced SH2-containing protein CIS belongs to the suppressor of cytokine signaling (SOCS) protein family. Here, we show the critical role of CIS in suppressing natural killer (NK) cell control of tumor initiation and metastasis. Cish-def
Externí odkaz:
https://doaj.org/article/45a7b428218746fa9e8645f73d323ab5
Autor:
Kevin Kos, Karin E. de Visser
Publikováno v:
Annual review of cancer biology
The microenvironment of breast cancer hosts a dynamic cross talk between diverse players of the immune system. While cytotoxic immune cells are equipped to control tumor growth and metastasis, tumor-corrupted immunosuppressive immune cells strive to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a949cfe5a1f7d38a0d35cb3c0860092b
https://doi.org/10.1146/annurev-cancerbio-042920-104912
https://doi.org/10.1146/annurev-cancerbio-042920-104912
Autor:
Kevin Kos, Muhammad A. Aslam, Rieneke van de Ven, Max D. Wellenstein, Wietske Pieters, Antoinette van Weverwijk, Danique E.M. Duits, Kim van Pul, Cheei-Sing Hau, Kim Vrijland, Daphne Kaldenbach, Elisabeth A.M. Raeven, Sergio A. Quezada, Rudi Beyaert, Heinz Jacobs, Tanja D. de Gruijl, Karin E. de Visser
Publikováno v:
CELL REPORTS
Cell Reports, 38(9):110447. Cell Press
Kos, K, Aslam, M A, van de Ven, R, Wellenstein, M D, Pieters, W, van Weverwijk, A, Duits, D E M, van Pul, K, Hau, C-S, Vrijland, K, Kaldenbach, D, Raeven, E A M, Quezada, S A, Beyaert, R, Jacobs, H, de Gruijl, T D & de Visser, K E 2022, ' Tumor-educated Tregs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche ', Cell Reports, vol. 38, no. 9, 110447 . https://doi.org/10.1016/j.celrep.2022.110447
Cell Reports, 38(9):110447. Cell Press
Kos, K, Aslam, M A, van de Ven, R, Wellenstein, M D, Pieters, W, van Weverwijk, A, Duits, D E M, van Pul, K, Hau, C-S, Vrijland, K, Kaldenbach, D, Raeven, E A M, Quezada, S A, Beyaert, R, Jacobs, H, de Gruijl, T D & de Visser, K E 2022, ' Tumor-educated Tregs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche ', Cell Reports, vol. 38, no. 9, 110447 . https://doi.org/10.1016/j.celrep.2022.110447
Breast cancer is accompanied by systemic immunosuppression, which facilitates metastasis formation, but how this shapes organotropism of metastasis is poorly understood. Here, we investigate the impact of mammary tumorigenesis on regulatory T cells (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e23db27f6ed5bdc3970977687df72d7
https://doi.org/10.1016/j.celrep.2022.110447
https://doi.org/10.1016/j.celrep.2022.110447
Autor:
Olga S, Blomberg, Lorenzo, Spagnuolo, Hannah, Garner, Leonie, Voorwerk, Olga I, Isaeva, Ewald, van Dyk, Noor, Bakker, Myriam, Chalabi, Chris, Klaver, Maxime, Duijst, Kelly, Kersten, Marieke, Brüggemann, Dorien, Pastoors, Cheei-Sing, Hau, Kim, Vrijland, Elisabeth A M, Raeven, Daphne, Kaldenbach, Kevin, Kos, Inna S, Afonina, Paulien, Kaptein, Louisa, Hoes, Willemijn S M E, Theelen, Paul, Baas, Emile E, Voest, Rudi, Beyaert, Daniela S, Thommen, Lodewyk F A, Wessels, Karin E, de Visser, Marleen, Kok
Publikováno v:
Cancer cell.
Immune checkpoint blockade (ICB) has heralded a new era in cancer therapy. Research into the mechanisms underlying response to ICB has predominantly focused on T cells; however, effective immune responses require tightly regulated crosstalk between i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::858404ab7e5b5d36c2dd670afa56af35
https://pubmed.ncbi.nlm.nih.gov/36525971
https://pubmed.ncbi.nlm.nih.gov/36525971
Autor:
Olga S. Blomberg, Lorenzo Spagnuolo, Hannah Garner, Leonie Voorwerk, Olga I. Isaeva, Ewald van Dyk, Noor Bakker, Myriam Chalabi, Chris Klaver, Maxime Duijst, Kelly Kersten, Marieke Brüggemann, Dorien Pastoors, Cheei-Sing Hau, Kim Vrijland, Elisabeth A.M. Raeven, Daphne Kaldenbach, Kevin Kos, Inna S. Afonina, Paulien Kaptein, Louisa Hoes, Willemijn S.M.E. Theelen, Paul Baas, Emile E. Voest, Rudi Beyaert, Daniela S. Thommen, Lodewyk F.A. Wessels, Karin E. de Visser, Marleen Kok
Publikováno v:
CANCER CELL
Immune checkpoint blockade (ICB) has heralded a new era in cancer therapy. Research into the mechanisms underlying response to ICB has predominantly focused on T cells; however, effective immune responses require tightly regulated crosstalk between i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad37e511061ec36826986b3010056ea
https://doi.org/10.1016/j.ccell.2022.11.014
https://doi.org/10.1016/j.ccell.2022.11.014
Autor:
Carola Ries, Chia Huey Ooi, Kevin Kos, Seth B. Coffelt, Antoinette van Weverwijk, Kelly Kersten, Ji-Ying Song, Joachim L. Schultze, Jos Jonkers, Philippe A. Cassier, Camilla Salvagno, Karin E. de Visser, Sander Tuit, Metamia Ciampricotti, Dominik Rüttinger, Kim Vrijland, Thomas Ulas, Cheei-Sing Hau
Publikováno v:
Nature cell biology
Nature cell biology 21(4), 511-521 (2019). doi:10.1038/s41556-019-0298-1
Nature cell biology 21(4), 511-521 (2019). doi:10.1038/s41556-019-0298-1
Recent studies have revealed a role for macrophages and neutrophils in limiting chemotherapy efficacy; however, the mechanisms underlying the therapeutic benefit of myeloid-targeting agents in combination with chemotherapy are incompletely understood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb54a9a82b5f59a0fbd18fba2a213eae
https://doi.org/10.1038/s41556-019-0298-1
https://doi.org/10.1038/s41556-019-0298-1
Autor:
Kevin, Kos, Muhammad A, Aslam, Rieneke, van de Ven, Max D, Wellenstein, Wietske, Pieters, Antoinette, van Weverwijk, Danique E M, Duits, Kim, van Pul, Cheei-Sing, Hau, Kim, Vrijland, Daphne, Kaldenbach, Elisabeth A M, Raeven, Sergio A, Quezada, Rudi, Beyaert, Heinz, Jacobs, Tanja D, de Gruijl, Karin E, de Visser
Publikováno v:
Cell reports. 38(9)
Breast cancer is accompanied by systemic immunosuppression, which facilitates metastasis formation, but how this shapes organotropism of metastasis is poorly understood. Here, we investigate the impact of mammary tumorigenesis on regulatory T cells (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c8f530370745d6f9c8359b3997cbaf80
https://pubmed.ncbi.nlm.nih.gov/35235800
https://pubmed.ncbi.nlm.nih.gov/35235800