Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kevin Klucher"'
Autor:
Markus Mordstein, Georg Kochs, Laure Dumoutier, Jean-Christophe Renauld, Søren R Paludan, Kevin Klucher, Peter Staeheli
Publikováno v:
PLoS Pathogens, Vol 4, Iss 9, p e1000151 (2008)
Virus-infected cells secrete a broad range of interferon (IFN) subtypes which in turn trigger the synthesis of antiviral factors that confer host resistance. IFN-alpha, IFN-beta and other type I IFNs signal through a common universally expressed cell
Externí odkaz:
https://doaj.org/article/88816b7acdfe41398559f0c9bc94545f
Autor:
Antonio Jimeno, Razelle Kurzrock, Diana F. Hausman, Scott Peterson, S. Gail Eckhardt, Roy S. Herbst, Kevin Klucher, Alex C. H. Vo, Cindy L. O'Bryant, Goldy C. George, Wells A. Messersmith, Gerald S. Falchook, Daniel W. Bowles, David S. Hong
PDF file, 84KB.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43591d7a0391edcb843dba8717266ae5
https://doi.org/10.1158/1078-0432.22446678.v1
https://doi.org/10.1158/1078-0432.22446678.v1
Autor:
Antonio Jimeno, Razelle Kurzrock, Diana F. Hausman, Scott Peterson, S. Gail Eckhardt, Roy S. Herbst, Kevin Klucher, Alex C. H. Vo, Cindy L. O'Bryant, Goldy C. George, Wells A. Messersmith, Gerald S. Falchook, Daniel W. Bowles, David S. Hong
PDF file, 70KB, Platelet P-AKT Inhibition.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4320189e938a93e98b59c20bc7b64e82
https://doi.org/10.1158/1078-0432.22446684
https://doi.org/10.1158/1078-0432.22446684
Autor:
Antonio Jimeno, Razelle Kurzrock, Diana F. Hausman, Scott Peterson, S. Gail Eckhardt, Roy S. Herbst, Kevin Klucher, Alex C. H. Vo, Cindy L. O'Bryant, Goldy C. George, Wells A. Messersmith, Gerald S. Falchook, Daniel W. Bowles, David S. Hong
PDF file, 36KB.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e07b7087bdf37347b8b4f2b5789313b
https://doi.org/10.1158/1078-0432.22446681
https://doi.org/10.1158/1078-0432.22446681
Autor:
Antonio Jimeno, Razelle Kurzrock, Diana F. Hausman, Scott Peterson, S. Gail Eckhardt, Roy S. Herbst, Kevin Klucher, Alex C. H. Vo, Cindy L. O'Bryant, Goldy C. George, Wells A. Messersmith, Gerald S. Falchook, Daniel W. Bowles, David S. Hong
PDF file, 54KB, Mutational Status for Arm 1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e6673435a2ee46faf887e249cbace5
https://doi.org/10.1158/1078-0432.22446675
https://doi.org/10.1158/1078-0432.22446675
Autor:
Antonio Jimeno, Razelle Kurzrock, Diana F. Hausman, Scott Peterson, S. Gail Eckhardt, Roy S. Herbst, Kevin Klucher, Alex C. H. Vo, Cindy L. O'Bryant, Goldy C. George, Wells A. Messersmith, Gerald S. Falchook, Daniel W. Bowles, David S. Hong
Purpose: The objectives of the study were to evaluate the maximum tolerated dose (MTD), safety, pharmacodynamics, pharmacokinetics, and antitumor activity of PX-866 in patients with incurable cancers.Experimental Design: This was a phase I, open-labe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55f392394cf359f81291540a0f4fb76f
https://doi.org/10.1158/1078-0432.c.6520830.v1
https://doi.org/10.1158/1078-0432.c.6520830.v1
Autor:
Cara H. Nelson, Christopher Jones, Lois Lee, Tonya Marmon, Diana Chung, Kevin Klucher, Yizhao Li, Erin Quirk, Daria Crittenden
Publikováno v:
Journal of Hepatology. 77:S88
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cbc0b4de9f690be041ff8c6225b32a5
https://doi.org/10.1016/s0168-8278(22)00569-4
https://doi.org/10.1016/s0168-8278(22)00569-4
Autor:
Erin Quirk, Feng Jin, Pengfei Guo, Daria B. Crittenden, Yujin Wang, Christopher T. Jones, Martijn Fenaux, Michael Charlton, Kevin Klucher, Clarence Eng, Qiong Zhang, Diana Chung
Publikováno v:
Clinical pharmacology in drug developmentReferences. 10(10)
TERN-101 is a nonsteroidal farnesoid X-receptor agonist being developed for the treatment of nonalcoholic steatohepatitis (NASH). We assessed the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of TERN-101 capsule and tablet formulations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c9f9efd50bbe3d9b1daaf36d8ddb6b
https://pubmed.ncbi.nlm.nih.gov/34302449
https://pubmed.ncbi.nlm.nih.gov/34302449
Autor:
Christopher T. Jones, Yujin Wang, Kevin Klucher, Martijn Fenaux, Thorsten A. Kirschberg, Randall L. Halcomb, Xu Yingzi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127465
Use of the oxadiazolone acid isostere in triiodothyronine analogs yielded potent and selective agonists for the thyroid hormone receptor β. Selected examples showed good in-vivo efficacy in a rat hypercholesterolemic model. One compound was further
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87dd03ad35846346953048e33ae94c6
https://doi.org/10.1016/j.bmcl.2020.127465
https://doi.org/10.1016/j.bmcl.2020.127465
Publikováno v:
Journal of Hepatology. 73:S684
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96c4decb2d2ec12aec630fe031ae4c99
https://doi.org/10.1016/s0168-8278(20)31829-8
https://doi.org/10.1016/s0168-8278(20)31829-8