Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Kevin Klein"'
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
Recent advances in synthetic drug manufacturing have introduced a new dynamic to the European regulatory system, with chemically synthesized polypeptide products using biological originator products as their reference medicine. Whereas biosimilars ar
Externí odkaz:
https://doaj.org/article/492c4dcbe04b41718470cc9df0ffdd3c
Autor:
Nicoletta Zedda, Katie Meheux, Jens Blöcher, Yoan Diekmann, Alexander V. Gorelik, Martin Kalle, Kevin Klein, Anna-Lena Titze, Laura Winkelbach, Elise Naish, Laurent Brou, François Valotteau, Foni Le Brun-Ricalens, Joachim Burger, Maxime Brami
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Joint inhumations of adults and children are an intriguing aspect of the shift from collective to single burial rites in third millennium BC Western Eurasia. Here, we revisit two exceptional Beaker period adult–child graves using ancient D
Externí odkaz:
https://doaj.org/article/e4be52af7c414886b30e221eda8ac6e5
Autor:
Ravi Bhoja, Matthew W. Ryan, Kevin Klein, Abu Minhajuddin, Emily Melikman, Mohamed Hamza, Bradley F. Marple, David L. McDonagh
Publikováno v:
Laryngoscope Investigative Otolaryngology, Vol 5, Iss 3, Pp 348-353 (2020)
Abstract Background Multimodal perioperative analgesia including acetaminophen is recommended by current guidelines. The comparative efficacy of intravenous vs oral acetaminophen in sinus surgery is unknown. We aimed to determine whether intravenous
Externí odkaz:
https://doaj.org/article/22f6299587f24a2384cde0d4595c2423
Publikováno v:
Brain Sciences, Vol 10, Iss 12, p 973 (2020)
Background: The trigeminocardiac reflex (TCR) is a brainstem reflex following stimulation of the trigeminal nerve, resulting in bradycardia, asystole and hypotension. It has been described in maxillofacial and craniofacial surgeries. This case series
Externí odkaz:
https://doaj.org/article/2e8894f51cad43cd85f59c1c40b3e973
Publikováno v:
BioDrugs. 37:235-245
Current knowledge is limited about which manufacturers are active in the global field of biopharmaceutical product development and how many unique follow-on biologics are approved in global markets.This study aimed to provide a cross-sectional overvi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c44d67b158bbfba8ef2579aa2424db
https://doi.org/10.1007/s40259-022-00568-0
https://doi.org/10.1007/s40259-022-00568-0
Text generation models originally developed for natural language processing have proven to be successful in generating protein sequences. These models are often finetuned for improved performance on more specific tasks, such as generation of proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::346e0791e919fc5cbe4f8fbf1b23875a
https://doi.org/10.1101/2023.02.28.530492
https://doi.org/10.1101/2023.02.28.530492
Autor:
Kevin Klein
Publikováno v:
Information Display. 38:24-29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53f270d4f266adddc7da9822347084e8
https://doi.org/10.1002/msid.1274
https://doi.org/10.1002/msid.1274
Autor:
Vinod P. Shah, Jon S. B. de Vlieger, Scott E McNeil, Kevin Klein, Beat Flühmann, Gerrit Borchard
Publikováno v:
Annals of the New York Academy of Sciences
The diverse nature of complex drug products poses challenges for the development of regulatory guidelines for generic versions. While complexity is not new in medicines, the technical capacity to measure and analyze data has increased. This requires
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5be4cccf2ce1fc092d8b17e2e0f75b66
https://doi.org/10.1111/nyas.14662
https://doi.org/10.1111/nyas.14662
Publikováno v:
Therapeutic innovationregulatory science. 56(2)
The COVID-19 pandemic required urgency in the development and delivery of effective vaccines and therapeutics; meanwhile, ongoing clinical research, regulation and supply for other much-needed therapeutics and vaccines needed to be sustained. In Euro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::833cdbd4fca6c79aeb3dd6d073df9fe7
https://pubmed.ncbi.nlm.nih.gov/35129827
https://pubmed.ncbi.nlm.nih.gov/35129827
Publikováno v:
Klein, K, Hazell, L, Stolk, P & Shakir, S 2019, ' The UK BIO-TRAC Study: a cross-sectional study of product and batch traceability for biologics in clinical practice and electronic adverse drug reaction reporting in the UK ', Drug Safety . https://doi.org/10.1007/s40264-019-00891-6
Drug Safety
Drug Safety
Introduction Due to the complexity of biologics and the inherent challenges for manufacturing, it is important to know the specific brand name and batch number of suspected biologics in adverse drug reaction (ADR) reports. Objective The aim of this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848fbd98cb65642efdff35114b6a661e
https://eprints.soton.ac.uk/439097/
https://eprints.soton.ac.uk/439097/