Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kevin Khovananth"'
Autor:
Elaine Pirie, Bruce Beutler, David Nemazee, Philippe Krebs, Christoph Huber, Nora G. Smart, Kevin Khovananth, Gunilla B. Karlsson Hedestam, Yu Xia, Michael Berger, Celine Eidenschenk, Gerald M. McInerney, Owen M. Siggs, Carrie N. Arnold
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Null alleles of the gene encoding NEMO (NF-κB essential modulator) are lethal in hemizygous mice and men, whereas hypomorphic alleles typically cause a syndrome of immune deficiency and ectodermal dysplasia. Here we describe an allele of Ikbkg in mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e369d1dd81e1b7daa09ce8dd8244008
https://ora.ox.ac.uk/objects/uuid:06c08181-70d5-48dd-aa47-844e2ab8ef77
https://ora.ox.ac.uk/objects/uuid:06c08181-70d5-48dd-aa47-844e2ab8ef77
An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence
Autor:
Owen M. Siggs, Brian R. Lawson, Ben A. Croker, Kevin Khovananth, Takashi Satoh, Daniel L. Popkin, Karine Crozat, Michael Berger, Philippe Krebs, Yu Xia, Osamu Takeuchi, Shizuo Akira, Xiaohong Li, Bruce Beutler, Argyrios N. Theofilopoulos, Xin Du, Eva Marie Y Moresco
Publikováno v:
Nature Immunology
Here we describe a previously unknown form of inherited immunodeficiency revealed by an N-ethyl-N-nitrosourea-induced mutation called elektra. Mice homozygous for this mutation showed enhanced susceptibility to bacterial and viral infection and dimin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83df227f65f078113128d9240bfd8732
https://ora.ox.ac.uk/objects/uuid:39bf148a-44de-4326-a558-3b4b51b92cae
https://ora.ox.ac.uk/objects/uuid:39bf148a-44de-4326-a558-3b4b51b92cae
Autor:
Michael J. Barnes, Kevin Khovananth, Philippe Krebs, Halil Aksoylar, Kasper Hoebe, Mitchell Kronenberg, Geoffrey W. Butcher, Amy Saunders, Bruce Beutler, Tristan Bourdeau, Sosathya Sovath, H. Leighton Grimes, Carrie N. Arnold, David A. Hildeman, Yu Xia, Kristin Lampe, Eleana Laws, Isaac Engel, Kris A. Steinbrecher
Publikováno v:
Journal of Immunology
Homeostatic control of the immune system involves mechanisms that ensure the self-tolerance, survival and quiescence of hematopoietic-derived cells. In this study, we demonstrate that the GTPase of immunity associated protein (Gimap)5 regulates these
Autor:
Katharina Brandl, Bruce Beutler, Amanda L. Blasius, Nengming Xiao, Kevin Khovananth, Yu Xia, Philippe Krebs, Celine Eidenschenk, Nora G. Smart
Publikováno v:
J Immunol
Journal of Immunology
Journal of Immunology
Sluggish was identified in a population of third generation mice descended from N-ethyl-N-nitrosourea-mutagenized sires. Macrophages from homozygotes exhibited impaired TNF-α production in response to all TLR ligands tested and displayed impaired ty
Autor:
Amanda L. Blasius, Philippe Krebs, Nora G. Smart, Yu Xia, Zaverio M. Ruggeri, Katharina Brandl, Antonella Zampolli, Kevin Khovananth, Karine Crozat, Bruce Beutler
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
The classical recessive coat color mutation misty ( m ) arose spontaneously on the DBA/J background and causes generalized hypopigmentation and localized white-spotting in mice, with a lack of pigment on the belly, tail tip, and paws. Here we describ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::137e26f743f425f43df5cff9dd4b78d2
https://europepmc.org/articles/PMC2650330/
https://europepmc.org/articles/PMC2650330/
Autor:
Xin Du, Pauline Lee, Bruce Beutler, Terri Gelbart, Eva Marie Y Moresco, Jaroslav Truksa, Navjiwan Mann, Ernest Beutler, Kevin Khovananth, Yu Xia, Suzanne Mudd, Ellen She
Hepcidin, a liver-derived protein that restricts enteric iron absorption, is the key regulator of body iron content. Several proteins induce expression of the hepcidin-encoding gene Hamp in response to infection or high levels of iron. However, mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c893052dfcee36fadd327c909d10f02
https://europepmc.org/articles/PMC2430097/
https://europepmc.org/articles/PMC2430097/
Autor:
Manfred R. Koller, Kevin Khovananth, Timothy M. Eisfeld, Bernhard O. Palsson, Robert O'Neal, Elie G. Hanania
Publikováno v:
SPIE Proceedings.
High-dose chemotherapy, followed by autologous hematopoietic stem cell (HSC) transplantation, is widely used for the treatment of cancer. However, contaminating tumor cells within HSC harvests continue to be of major concern since re-infused tumor ce