Zobrazeno 1 - 10
of 269
pro vyhledávání: '"Kevin K. Lin"'
Autor:
Olivier Colomban, Elizabeth M. Swisher, Rebecca Kristeleit, Iain McNeish, Ronnie Shapira-Frommer, Sandra Goble, Kevin K. Lin, Lara Maloney, Gilles Freyer, Benoit You
Publikováno v:
EBioMedicine, Vol 89, Iss , Pp 104477- (2023)
Summary: Background: PARP inhibitors (PARPi) have revolutionized the management of advanced ovarian carcinoma, and were investigated as forefront treatment in recurrent disease. The objective was to explore if mathematical modeling of the early longi
Externí odkaz:
https://doaj.org/article/8424b6b7464c47abaf85ca637a1499c4
Autor:
Elizabeth M. Swisher, Tanya T. Kwan, Amit M. Oza, Anna V. Tinker, Isabelle Ray-Coquard, Ana Oaknin, Robert L. Coleman, Carol Aghajanian, Gottfried E. Konecny, David M. O’Malley, Alexandra Leary, Diane Provencher, Stephen Welch, Lee-may Chen, Andrea E. Wahner Hendrickson, Ling Ma, Prafull Ghatage, Rebecca S. Kristeleit, Oliver Dorigo, Ashan Musafer, Scott H. Kaufmann, Julia A. Elvin, Douglas I. Lin, Setsuko K. Chambers, Erin Dominy, Lan-Thanh Vo, Sandra Goble, Lara Maloney, Heidi Giordano, Thomas Harding, Alexander Dobrovic, Clare L. Scott, Kevin K. Lin, Iain A. McNeish
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The identification of biomarkers of response to PARP inhibitors can enable selection of appropriate ovarian cancer patients for treatment. In this study, the authors report clinical results and exploratory biomarker analyses from the ARIEL2 phase 2 c
Externí odkaz:
https://doaj.org/article/4c0bb318d2464bacb5fcd01f6ceefda3
Autor:
Olga Kondrashova, Monique Topp, Ksenija Nesic, Elizabeth Lieschke, Gwo-Yaw Ho, Maria I. Harrell, Giada V. Zapparoli, Alison Hadley, Robert Holian, Emma Boehm, Valerie Heong, Elaine Sanij, Richard B. Pearson, John J. Krais, Neil Johnson, Orla McNally, Sumitra Ananda, Kathryn Alsop, Karla J. Hutt, Scott H. Kaufmann, Kevin K. Lin, Thomas C. Harding, Nadia Traficante, Australian Ovarian Cancer Study (AOCS), Anna deFazio, Iain A. McNeish, David D. Bowtell, Elizabeth M. Swisher, Alexander Dobrovic, Matthew J. Wakefield, Clare L. Scott
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Around 10% of high-grade serous ovarian carcinomas (HGSOC) harbor BRCA1 promoter methylation, but it is uncertain how it predicts response to PARP inhibition. Here, the authors show that homozygous BRCA1 methylation predicts response to rucaparib whi
Externí odkaz:
https://doaj.org/article/daa72fc740814394b7993401524f3f72
Autor:
Hsien-Ming Hu, Xin Zhao, Swati Kaushik, Lilliane Robillard, Antoine Barthelet, Kevin K. Lin, Khyati N. Shah, Andy D. Simmons, Mitch Raponi, Thomas C. Harding, Sourav Bandyopadhyay
Publikováno v:
Cell Reports, Vol 23, Iss 3, Pp 918-929 (2018)
Summary: Chemotherapy is used to treat most cancer patients, yet our understanding of factors that dictate response and resistance to such drugs remains limited. We report the generation of a quantitative chemical-genetic interaction map in human mam
Externí odkaz:
https://doaj.org/article/c909b47692df44cdb6150df68cfc7bc1
Autor:
Rebecca S. Kristeleit, Yvette Drew, Amit M. Oza, Susan M. Domchek, Susana Banerjee, Rosalind M. Glasspool, Judith Balmaña, Lee-may Chen, Manish R. Patel, Howard A. Burris, Tamar Safra, Jennifer Borrow, Kevin K. Lin, Sandra Goble, Lara Maloney, Ronnie Shapira-Frommer
Publikováno v:
British Journal of Cancer. 128:255-265
Autor:
Dirk Zboralski, Aileen Hoehne, Anne Bredenbeck, Anne Schumann, Minh Nguyen, Eberhard Schneider, Jan Ungewiss, Matthias Paschke, Christian Haase, Jan L. von Hacht, Tanya Kwan, Kevin K. Lin, Jan Lenore, Thomas C. Harding, Jim Xiao, Andrew D. Simmons, Ajay-Mohan Mohan, Nicola Beindorff, Ulrich Reineke, Christiane Smerling, Frank Osterkamp
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 49:3651-3667
Purpose Fibroblast activation protein (FAP) is a membrane-bound protease that has limited expression in normal adult tissues but is highly expressed in the tumor microenvironment of many solid cancers. FAP-2286 is a FAP-binding peptide coupled to a r
Autor:
Clare L. Scott, Kevin K. Lin, Elizabeth M. Swisher, Iain A. McNeish, Mitch Raponi, Thomas C. Harding, Andrew D. Simmons, Scott H. Kaufmann, Matthew J. Wakefield, Heidi Giordano, David Bowtell, Lara Maloney, Liliane Robillard, James Sun, Amit Oza, David M. O'Malley, Ganessan Kichenadasse, Michael Friedlander, Anne Floquet, Robert L. Coleman, Kara A. Bernstein, Gregory J. Brunette, Meghan R. Sullivan, Elizabeth M. Kass, Rohit Prakash, Maria Jasin, Holly Barker, Gwo-Yaw Ho, Michael J. Kuiper, Maria I. Harrell, Nelson N.H. Teng, Anna V. Tinker, Kristy Shield-Artin, Minh Nguyen, Olga Kondrashova
A list of copy number alterations, rearrangements and short variants detected by Foundation Medicine NGS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::290d4db2a909f21e74c4707ffaf15b8c
https://doi.org/10.1158/2159-8290.22532014
https://doi.org/10.1158/2159-8290.22532014
Autor:
Elizabeth M. Swisher, Iain A. McNeish, Thomas C. Harding, James D. Brenton, Heidi Giordano, James X. Sun, Robert L. Coleman, Gottfried E. Konecny, Clare L. Scott, Scott H. Kaufmann, Setsuko K. Chambers, David M. O'Malley, Lara Maloney, Jeffrey D. Isaacson, Elaina Mann, Lan-Thanh Vo, Carmen Say, Marc R. Radke, Elena Helman, Anna V. Tinker, Isabelle Ray-Coquard, Ana Oaknin, Amit M. Oza, Maria I. Harrell, Kevin K. Lin
Table S2 shows data concerning the association between baseline characteristics and presence of BRCA reversion mutations in pretreatment circulating cell-free DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b5b7336d23449439404d62f9040a376
https://doi.org/10.1158/2159-8290.22532687.v1
https://doi.org/10.1158/2159-8290.22532687.v1
Autor:
Clare L. Scott, Kevin K. Lin, Elizabeth M. Swisher, Iain A. McNeish, Mitch Raponi, Thomas C. Harding, Andrew D. Simmons, Scott H. Kaufmann, Matthew J. Wakefield, Heidi Giordano, David Bowtell, Lara Maloney, Liliane Robillard, James Sun, Amit Oza, David M. O'Malley, Ganessan Kichenadasse, Michael Friedlander, Anne Floquet, Robert L. Coleman, Kara A. Bernstein, Gregory J. Brunette, Meghan R. Sullivan, Elizabeth M. Kass, Rohit Prakash, Maria Jasin, Holly Barker, Gwo-Yaw Ho, Michael J. Kuiper, Maria I. Harrell, Nelson N.H. Teng, Anna V. Tinker, Kristy Shield-Artin, Minh Nguyen, Olga Kondrashova
Supplementary Tables, Figures and Video legends, Tables 2,3,5 and all Supplementary Figures. Supplementary Table 2. Confirmation of cis configuration of BRCA1 primary and secondary mutations in case 4 by colony PCR. Supplementary Table 3. IC50 (mirco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::397e20de6afaeebadb9878c50aa24cdb
https://doi.org/10.1158/2159-8290.22532005
https://doi.org/10.1158/2159-8290.22532005
Autor:
Elizabeth M. Swisher, Iain A. McNeish, Thomas C. Harding, James D. Brenton, Heidi Giordano, James X. Sun, Robert L. Coleman, Gottfried E. Konecny, Clare L. Scott, Scott H. Kaufmann, Setsuko K. Chambers, David M. O'Malley, Lara Maloney, Jeffrey D. Isaacson, Elaina Mann, Lan-Thanh Vo, Carmen Say, Marc R. Radke, Elena Helman, Anna V. Tinker, Isabelle Ray-Coquard, Ana Oaknin, Amit M. Oza, Maria I. Harrell, Kevin K. Lin
A key resistance mechanism to platinum-based chemotherapies and PARP inhibitors in BRCA-mutant cancers is the acquisition of BRCA reversion mutations that restore protein function. To estimate the prevalence of BRCA reversion mutations in high-grade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c393b81f60afdff6fe8e9b164e1dfd80
https://doi.org/10.1158/2159-8290.c.6546800.v1
https://doi.org/10.1158/2159-8290.c.6546800.v1