Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Kevin Jude"'
Graph algorithms are challenging to implement due to their varying topology and irregular access patterns. Real-world graphs are dynamic in nature and routinely undergo edge and vertex additions, as well as, deletions. Typical examples of dynamic gra
Externí odkaz:
http://arxiv.org/abs/2305.17813
Autor:
Jonathan Roth, Yurii Perekopaiko, Danil A. Kozyrev, Shlomi Constantini, Hannah E. Myers, Benjamin L. Chern, Andrew Reisner, Jose Hinojosa Mena-Bernal, Andrea Bartoli, Luca Paun, Saqib Kamran Bakhshi, M Shahzad Shamim, Giuseppe Talamonti, R. Michael Scott, Nir Shimony, Ahmed El Damaty, Rodrigo Mierez, José Silva, Gustavo Sánchez, Andrea Di Rita, Lorenzo Genitori, Barbara Spacca, Yacine Felissi, Abdelhalim Morsli, Giselle Cardozo-Faust, Dhaval Shukla, Dwarakanath Srinivas, Kevin Jude Sudevan, Meriem Amarouche, J. André Grotenhuis, Hieronymus D. Boogaarts, Javier Márquez-Rivas, Mónica Rivero-Garvia, Philippe De Vloo, Frank Van Calenbergh, Henry W. S. Schroeder, Sascha Marx, Ehab El Refaee, Onur Ozgural, Eyüp Bayatli, Gökmen Kahiloğulları, Jayaratnam Jayamohan, Francesco T. Mangano, Jesse M. Skoch, Sudhakar Vadivelu, Charles B. Stevenson, Ricardo Brandao Fonseca, Igor Faquini, Mosaab Alsuwaihel, P. Daniel McNeely, Alexandre Varella Giannetti, Katalin Lorincz, Martin Schuhmann, Sandrine de-Ribaupierre, William C. Gump, Flavio Giordano, George I. Jallo, John Goodden, Ieva Sataite, Domenico Catapano, Ulrich-W. Thomale, Matthias Schulz, Luca Massimi, Gianpiero Tamburrini, Giuseppe Cinalli, Pietro Spennato, Vincent Jecko
Publikováno v:
Neuroscience Institute Publications
OBJECTIVE Colloid cysts (CCs) are rare at all ages, and particularly among children. The current literature on pediatric CC is limited, and often included in mixed adult/pediatric series. The goal of this multinational, multicenter study was to combi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459e1bcd62e3e05ee85a28c8d6ad2dac
https://ir.lib.uwo.ca/neurosci_inst_pubs/163
https://ir.lib.uwo.ca/neurosci_inst_pubs/163
Autor:
Kevin Jude, Viviane S. De Paula, K. Christopher Garcia, Santrupti Nerli, Caleb R. Glassman, Nikolaos G. Sgourakis
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance An extensive body of work has revealed that the conformational plasticity of IL-2 plays an important role in targeting the IL-2 receptor signaling axis in both agonist and antagonist mode; however, a more detailed understanding of such p
Autor:
Iva Marković, Lisa Kozodoy, Wei Yang, K. Christopher Garcia, Joon Sung Park, K. Verschueren, Samer Halabiya, Lance Stewart, Ashish Phal, Lauren Miller, Rameshwar U. Kadam, Kevin Jude, Nathaniel Bennett, Savvas N. Savvides, Steffen Benard, Brian Coventry, Lora Picton, Aerin Yang, Inna Goreshnik, David Baker, Hannele Ruohola-Baker, Kenneth Verstraete, Joseph Schlessinger, Longxing Cao, Scott T. R. Walsh, Bradley Hammerson, Michelle DeWitt, Buwei Huang, Sangwon Lee, Eva-Maria Strauch, Ian A. Wilson
The design of proteins that bind to a specific site on the surface of a target protein using no information other than the three-dimensional structure of the target remains an outstanding challenge. We describe a general solution to this problem whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e1c6f76f3ac461c48924b0145081c91
https://doi.org/10.1101/2021.09.04.459002
https://doi.org/10.1101/2021.09.04.459002
Autor:
Nam-Chul Ha, Andrew C.T. Ha, Calvin J. Kuo, Y. Miao, Kanako Yuki, K. Park, David Baker, Claudia Y. Janda, Kenan Christopher Garcia, Jenny Yuan, Mario Vallon, Kritika Mohan, Kevin Jude, J.G. Vilches-Moure, Luke T. Dang
Publikováno v:
Nature structural & molecular biology
To discriminate between closely related members of a protein family that differ at a limited number of spatially distant positions is a challenge for drug discovery. We describe a combined computational design and experimental selection approach for
Autor:
Lestat R. Ali, Javier Castellanos, K. Christopher Garcia, Stephanie J. Crowley, Tamara Biary, Gonçalo J. L. Bernardes, Daniel-Adriano Silva, Mikel Ruterbusch, David Baker, Isabel Leung, Carl Walkey, Brian D. Weitzner, Shawn Yu, Marion Pepper, Alfredo Quijano-Rubio, Enrique Marcos, Fátima Pardo-Avila, Umut Ulge, Lance Stewart, Kevin Jude, Stanley R. Riddell, Michael Dougan, Jamie B. Spangler, Lauren Carter, Carlos Labão-Almeida
Publikováno v:
Nature
© 2019 Springer Nature limited. All rights reserved.
We describe a de novo computational approach for designing proteins that recapitulate the binding sites of natural cytokines, but are otherwise unrelated in topology or amino acid sequence. W
We describe a de novo computational approach for designing proteins that recapitulate the binding sites of natural cytokines, but are otherwise unrelated in topology or amino acid sequence. W
Autor:
Marco Calafiore, Robert A. Saxton, K. Christopher Garcia, Lukas T. Henneberg, Alan M. Hanash, Kevin Jude, Leon Su
Publikováno v:
Immunity
Summary Interleukin-22 (IL-22) acts on epithelial cells to promote tissue protection and regeneration, but can also elicit pro-inflammatory effects, contributing to disease pathology. Here, we engineered a high-affinity IL-22 super-agonist that enabl
Autor:
Jie Wang, Marius Wernig, Zijun Sun, Ricardo A. Fernandes, Thomas C. Südhof, Rebecca Wicklein, Kevin Jude, Jinzhao Wang, K. Christopher Garcia, Yi Miao, Sean Merrill
Publikováno v:
Cell
Summary RTN4-binding proteins were widely studied as “NoGo” receptors, but their physiological interactors and roles remain elusive. Similarly, BAI adhesion-GPCRs were associated with numerous activities, but their ligands and functions remain un
Autor:
Deepa Waghray, Nanda G. Aduri, John S Burg, K. Christopher Garcia, Anthony A. Kossiakoff, Cornelius Gati, Kevin Jude, Yi Miao, Naotaka Tsutsumi, Somnath Mukherjee, Claudia Y. Janda
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
Frizzleds (Fzd) are the primary receptors for Wnt morphogens, which are essential regulators of stem cell biology, yet the structural basis of Wnt signaling through Fzd remains poorly understood. Here we report the structure of an unliganded human Fz
Autor:
Nanda G. Aduri, John S Burg, Yi Miao, Naotaka Tsutsumi, Anthony A. Kossiakoff, Deepa Waghray, Cornelius Gati, K. Christopher Garcia, Somnath Mukherjee, Claudia Y. Janda, Kevin Jude
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcf1ce49f4f1932c5f8bcb9144f8bb73
https://doi.org/10.7554/elife.58464.sa2
https://doi.org/10.7554/elife.58464.sa2