Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Kevin J. Woollard"'
Autor:
Hiraku Tsujimoto, Azusa Hoshina, Shin-Ichi Mae, Toshikazu Araoka, Wang Changting, Yoshihiro Ijiri, May Nakajima-Koyama, Satoko Sakurai, Kazusa Okita, Ken Mizuta, Akira Niwa, Megumu K. Saito, Mitinori Saitou, Takuya Yamamoto, Cecilia Graneli, Kevin J. Woollard, Kenji Osafune
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113602- (2024)
Summary: Recent regenerative studies using human pluripotent stem cells (hPSCs) have developed multiple kidney-lineage cells and organoids. However, to further form functional segments of the kidney, interactions of epithelial and interstitial cells
Externí odkaz:
https://doaj.org/article/0ff925a8f95745d09e7a299bf70b6721
Autor:
Alexis Hofherr, Julie Williams, Li-Ming Gan, Magnus Söderberg, Pernille B. L. Hansen, Kevin J. Woollard
Publikováno v:
BMC Nephrology, Vol 23, Iss 1, Pp 1-17 (2022)
Abstract Diabetic kidney disease (DKD) is the leading cause of kidney failure worldwide. Mortality and morbidity associated with DKD are increasing with the global prevalence of type 2 diabetes. Chronic, sub-clinical, non-resolving inflammation contr
Externí odkaz:
https://doaj.org/article/441494f4155e41ac8b207d9608db287a
Autor:
Lisa Buvall, Robert I. Menzies, Julie Williams, Kevin J. Woollard, Chanchal Kumar, Anna B. Granqvist, Maria Fritsch, Denis Feliers, Anna Reznichenko, Davide Gianni, Slavé Petrovski, Claus Bendtsen, Mohammad Bohlooly-Y, Carolina Haefliger, Regina Fritsche Danielson, Pernille B. L. Hansen
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Kidney disease is a complex disease with several different etiologies and underlying associated pathophysiology. This is reflected by the lack of effective treatment therapies in chronic kidney disease (CKD) that stop disease progression. However, no
Externí odkaz:
https://doaj.org/article/6361614ed43a4724915ac1760b7334c8
Autor:
Yasaman Shamshirgaran, Anna Jonebring, Anna Svensson, Isabelle Leefa, Mohammad Bohlooly-Y, Mike Firth, Kevin J. Woollard, Alexis Hofherr, Ian M. Rogers, Ryan Hicks
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Recent advances in induced pluripotent stem cells (iPSCs), genome editing technologies and 3D organoid model systems highlight opportunities to develop new in vitro human disease models to serve drug discovery programs. An ideal disease mode
Externí odkaz:
https://doaj.org/article/671fd9f7c0264f90af36569f226a7d4c
Autor:
Danielle L. Michell, Waled A. Shihata, Karen L. Andrews, Nurul Aisha Zainal Abidin, Ann-Maree Jefferis, Amanda K. Sampson, Natalie G. Lumsden, Olivier Huet, Marie-Odile Parat, Garry L. Jennings, Robert G. Parton, Kevin J. Woollard, David M. Kaye, Jaye P. F. Chin-Dusting, Andrew J. Murphy
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The aetiology and progression of hypertension involves various endogenous systems, such as the renin angiotensin system, the sympathetic nervous system, and endothelial dysfunction. Recent data suggest that vascular inflammation may also pla
Externí odkaz:
https://doaj.org/article/89d56ef6af8740c7a60458ad31b61cc1
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
Background Intermittent claudication (IC) is a common manifestation of peripheral arterial disease. Some patients with IC experience a rise in Urinary N-acetyl-β-D-Glucosaminidase (NAG)/ Creatinine (Cr) ratio, a marker of renal injury, following exe
Externí odkaz:
https://doaj.org/article/59a2763bbfad49c7b17955f26192864b
Autor:
Adela Constantinescu-Bercu, Yuxiao A. Wang, Kevin J. Woollard, Pierre Mangin, Karen Vanhoorelbeke, James T.B. Crawley, Isabelle I. Salles-Crawley
Publikováno v:
Haematologica, Vol 107, Iss 4 (2021)
The GPIbT-VWF A1 domain interaction is essential for platelet tethering under high shear. Synergy between GPIbα and GPVI signaling machineries has been suggested previously, however its molecular mechanism remains unclear. We generated a novel GPIb
Externí odkaz:
https://doaj.org/article/419fac8344784940b97373c9c7ae8edd
Autor:
Jurij Kiefer, Johannes Zeller, Balázs Bogner, Isabel A. Hörbrand, Friederike Lang, Emil Deiss, Oscar Winninger, Mark Fricke, Sheena Kreuzaler, Eva Smudde, Markus Huber-Lang, Karlheinz Peter, Kevin J. Woollard, Steffen U. Eisenhardt
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Monocytes are the third most frequent type of leukocytes in humans, linking innate and adaptive immunity and are critical drivers in many inflammatory diseases. Based on the differential expression of surface antigens, three monocytic subpopulations
Externí odkaz:
https://doaj.org/article/1b84d004b23046238c29d1ac3260814d
Autor:
Evangelos Triantafyllou, Kevin J. Woollard, Mark J. W. McPhail, Charalambos G. Antoniades, Lucia A. Possamai
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Acute and acute-on-chronic liver failure (ALF and ACLF), though distinct clinical entities, are considered syndromes of innate immune dysfunction. Patients with ALF and ACLF display evidence of a pro-inflammatory state with local liver inflammation,
Externí odkaz:
https://doaj.org/article/30634139b4d8409ead9d5b3c752a09cc
Autor:
Maha F. Saja, Lucie Baudino, William D. Jackson, H. Terence Cook, Talat H. Malik, Liliane Fossati-Jimack, Marieta Ruseva, Matthew C. Pickering, Kevin J. Woollard, Marina Botto
Publikováno v:
Cell Reports, Vol 12, Iss 11, Pp 1802-1815 (2015)
Monocytes are heterogeneous effector cells involved in the maintenance and restoration of tissue integrity. However, their response to hyperlipidemia remains poorly understood. Here, we report that in the presence of elevated levels of triglyceride-r
Externí odkaz:
https://doaj.org/article/5859345b5b7b40f183e32b538ccfa259