Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Kevin J. Williams"'
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
The luminal surface of the endothelium is exposed to dynamic blood flow patterns that are known to affect endothelial cell phenotype. While many studies have documented the phenotypic changes by gene or protein expression, less is known about the rol
Externí odkaz:
https://doaj.org/article/2dbea7e9f32843fc8f11cc425472b336
Autor:
Dawoud Sulaiman, Dongyuan Wu, Lauren Page Black, Kevin J. Williams, Kiley Graim, Susmita Datta, Srinivasa T. Reddy, Faheem W. Guirgis
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 3, Pp n/a-n/a (2024)
Abstract The purpose of this study was to investigate changes in the lipidome of patients with sepsis to identify signaling lipids associated with poor outcomes that could be linked to future therapies. Adult patients with sepsis were enrolled within
Externí odkaz:
https://doaj.org/article/34b08e111f7b43588b4cdc74d3788069
Autor:
Elinor Lee, Kevin J. Williams, Cormac McCarthy, James P. Bridges, Elizabeth F. Redente, Thomas Q. de Aguiar Vallim, Robert A. Barrington, Tisha Wang, Elizabeth J. Tarling
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 2, Pp 100496- (2024)
Pulmonary alveolar proteinosis (PAP) is a life-threatening, rare lung syndrome for which there is no cure and no approved therapies. PAP is a disease of lipid accumulation characterized by alveolar macrophage foam cell formation. While much is known
Externí odkaz:
https://doaj.org/article/9fad4a1e80b7407aa9b6d0edaaa5b3ea
Autor:
Sicheng Zhang, Kevin J. Williams, Amandine Verlande-Ferrero, Alvin P. Chan, Gino B. Su, Erin E. Kershaw, James E. Cox, John Alan Maschek, Suzanne N. Shapira, Heather R. Christofk, Thomas Q. de Aguiar Vallim, Selma Masri, Claudio J. Villanueva
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 2, Pp 100434- (2024)
Adipose tissue is the site of long-term energy storage. During the fasting state, exercise, and cold exposure, the white adipose tissue mobilizes energy for peripheral tissues through lipolysis. The mobilization of lipids from white adipose tissue to
Externí odkaz:
https://doaj.org/article/ff3c3ea9925a42a1b4513e62d017e176
Autor:
Yvonne N. Flores, Aryana T. Amoon, Baolong Su, Rafael Velazquez-Cruz, Paula Ramírez-Palacios, Jorge Salmerón, Berenice Rivera-Paredez, Janet S. Sinsheimer, Aldons J. Lusis, Adriana Huertas-Vazquez, Sammy Saab, Beth A. Glenn, Folasade P. May, Kevin J. Williams, Roshan Bastani, Steven J. Bensinger
Publikováno v:
Lipids in Health and Disease, Vol 20, Iss 1, Pp 1-17 (2021)
Abstract Background Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease and cirrhosis. NAFLD is mediated by changes in lipid metabolism and known risk factors include obesity, metabolic syndrome, and diabetes. The aim
Externí odkaz:
https://doaj.org/article/37bef688082e4aa795640c4fb24a17e1
Publikováno v:
BMC Medical Education, Vol 20, Iss 1, Pp 1-10 (2020)
Abstract Background Mentoring is a critical component of career development and job satisfaction leading to a healthier workforce and more productive outputs. However, there are limited data on mentorship models in regional areas and in particular fo
Externí odkaz:
https://doaj.org/article/9e83ea695b614aca859a44e486261290
Autor:
Zhengyi Zhang, An-Chieh Feng, David Salisbury, Xin Liu, Xiaohui Wu, Jason Kim, Irina Lapina, Dan Wang, Brennan Lee, Josue Fraga, Calvin Pan, Kevin J. Williams, Aldons J. Lusis, Phil Scumpia, Tamer Sallam
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Heterogeneous nuclear ribonucleoproteins (hnRNPs) play critical roles in the biogenesis, localization and transport of RNA. Here authors investigate a role for hnRNPs in sterol metabolism in mice and provide insights into their role in selective prom
Externí odkaz:
https://doaj.org/article/646bf0de5fae4234ab6ca6f891819503
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100235- (2021)
Summary: Immune cells, such as macrophages, reprogram their lipid metabolism in response to the activation of pattern recognition receptors (e.g., TLRs, NLRs) and cytokine receptors (e.g., interferons, interleukins). Profiling these changes can be ac
Externí odkaz:
https://doaj.org/article/8bd1f09bb84349a581837452910e563d
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 2, Pp 460-468 (2017)
Stable isotope labeling has become an important methodology for determining lipid metabolic parameters of normal and neoplastic cells. Conventional methods for fatty acid and cholesterol analysis have one or more issues that limit their utility for i
Externí odkaz:
https://doaj.org/article/17de5abbf6d94b35bf08eb22491cb285
Autor:
Joseph P. Argus, Moses Q. Wilks, Quan D. Zhou, Wei Yuan Hsieh, Elvira Khialeeva, Xen Ping Hoi, Viet Bui, Shili Xu, Amy K. Yu, Eric S. Wang, Harvey R. Herschman, Kevin J. Williams, Steven J. Bensinger
Publikováno v:
Cell Reports, Vol 25, Iss 10, Pp 2919-2934.e8 (2018)
Summary: It is well understood that fatty acids can be synthesized, imported, and modified to meet requisite demands in cells. However, following the movement of fatty acids through the multiplicity of these metabolic steps has remained difficult. To
Externí odkaz:
https://doaj.org/article/482a607cb48f49f9b41f5484a29a328c