Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kevin J. Washicosky"'
Autor:
Sang Su Kwak, Kevin J. Washicosky, Emma Brand, Djuna von Maydell, Jenna Aronson, Susan Kim, Diane E. Capen, Murat Cetinbas, Ruslan Sadreyev, Shen Ning, Enjana Bylykbashi, Weiming Xia, Steven L. Wagner, Se Hoon Choi, Rudolph E. Tanzi, Doo Yeon Kim
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The relationship between amyloid-β species and tau pathology in Alzheimer’s disease is not fully understood. Here, the authors show that it is the increased ratio of amyloid-β42 and 40 isoforms drives tau pathology in 3D human neural cell culture
Externí odkaz:
https://doaj.org/article/0c1c3533dcca447694dd527474cb0871
Autor:
David G. Hunter, Frank Weng, Srikant Sarangi, Juliet A. Moncaster, Maria Ericsson, John I. Clark, Olga Minaeva, Yorghos Tripodis, Douglas S Parsons, Caitlin A Black, Kevin J. Washicosky, Robert D. Moir, Lee E. Goldstein, Rudolph E. Tanzi, Danielle M Ledoux
Publikováno v:
J Gerontol A Biol Sci Med Sci
The absence of clinical tools to evaluate individual variation in the pace of aging represents a major impediment to understanding aging and maximizing health throughout life. The human lens is an ideal tissue for quantitative assessment of molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1c1aca8d286683fd2c67b02adf4766
https://doi.org/10.1093/gerona/glaa121
https://doi.org/10.1093/gerona/glaa121
Autor:
Kevin J. Washicosky, Teryn Mitchell, Robert D. Moir, Deepak Kumar, Rudolph E. Tanzi, Xandra O. Breakefield, Bence György, William A. Eimer, Nanda Kumar N. Shanmugam, Alex S. Rodriguez
Publikováno v:
Neuron. 100:1527-1532
Summary Amyloid-β peptide (Aβ) fibrilization and deposition as β-amyloid are hallmarks of Alzheimer's disease (AD) pathology. We recently reported Aβ is an innate immune protein that protects against fungal and bacterial infections. Fibrilization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a62cf7317e55d3e7d0a5f2b6decb575
https://doi.org/10.1016/j.neuron.2018.11.043
https://doi.org/10.1016/j.neuron.2018.11.043
Autor:
Emma Brand, Sang Su Kwak, Susan Kim, Weiming Xia, Steven L. Wagner, Diane E. Capen, Shen Ning, Enjana Bylykbashi, Se Hoon Choi, Doo Yeon Kim, Djuna von Maydell, Ruslan I. Sadreyev, Rudolph E. Tanzi, Kevin J. Washicosky, Murat Cetinbas, Jenna Aronson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
The relationship between amyloid-β (Aβ) species and tau pathology in Alzheimer’s disease (AD) is not fully understood. Here, we provide direct evidence that Aβ42/40 ratio, not total Aβ level, plays a critical role in inducing neurofibrillary ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf7c47b9f6f50e8a6294e6b228037dd4
https://doi.org/10.1038/s41467-020-15120-3
https://doi.org/10.1038/s41467-020-15120-3
Autor:
Stephanie J Soscia, James E Kirby, Kevin J Washicosky, Stephanie M Tucker, Martin Ingelsson, Bradley Hyman, Mark A Burton, Lee E Goldstein, Scott Duong, Rudolph E Tanzi, Robert D Moir
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9505 (2010)
The amyloid beta-protein (Abeta) is believed to be the key mediator of Alzheimer's disease (AD) pathology. Abeta is most often characterized as an incidental catabolic byproduct that lacks a normal physiological role. However, Abeta has been shown to
Externí odkaz:
https://doaj.org/article/42b9b2344e1f41cbb83e8af082698963
Autor:
Alex S. Rodriguez, Rudolph E. Tanzi, Bence György, William A. Eimer, Xandra O. Breakefield, Deepak Kumar, Robert D. Moir, Kevin J. Washicosky, Nanda Kumar N. Shanmugam
Publikováno v:
SSRN Electronic Journal.
Amyloid-β peptide (Aβ) fibrilization and deposition as β-amyloid is a hallmark Alzheimer's disease (AD) pathology. We recently reported Aβ is an innate immune protein and the peptides expression protects against fungal and bacterial infections in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b5dacbcb9aa94409fa9b2a3e481cb18
https://doi.org/10.2139/ssrn.3155923
https://doi.org/10.2139/ssrn.3155923
Autor:
Rudolph E. Tanzi, Hui Zheng, Yiying Zhang, Kevin J. Washicosky, Zhongcong Xie, Dennis W. Burke, N. Sunder, Celeste A. Swain, Catherine A. Crosby, Janet Sherman, Edward R. Marcantonio, Yuanlin Dong, Sarah A. P. Ward, Sayre McAuliffe
Publikováno v:
Annals of Surgery. 258:364-369
Postoperative cognitive change (POCC) or postoperative cognitive dysfunction (POCD)1,2 (reviewed in Silverstein et al3 and Terrando et al4) is one of the most common postoperative complications in older adults who have undergone surgery5 and is assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e5b24425075659da47f73047efb151
https://doi.org/10.1097/sla.0b013e318298b077
https://doi.org/10.1097/sla.0b013e318298b077
Autor:
Rudolph E. Tanzi, Robert D. Moir, John I. Clark, Srikant Sarangi, Olga Minaeva, Caitlin Rook, Danielle Ledoux, Maria Ericsson, Lee E. Goldstein, Kevin J. Washicosky, David G. Hunter, Yorghos Tripodis, Juliet A. Moncaster
Publikováno v:
Alzheimer's & Dementia. 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3e5118da824485cc38da86b491c91bb
https://doi.org/10.1016/j.jalz.2016.06.2156
https://doi.org/10.1016/j.jalz.2016.06.2156
Autor:
Se Hoon Choi, Jessica Ghofrani, Stephanie Tucker, Rudolph E. Tanzi, Robert D. Moir, Lee E. Goldstein, Kevin J. Washicosky, Deepak Kumar, Gawain McColl, Aaron Lefkowitz, William A. Eimer
Publikováno v:
Science translational medicine. 8(340)
The amyloid-β peptide (Aβ) is a key protein in Alzheimer’s disease (AD) pathology. We previously reported in vitro evidence suggesting that Aβ is an antimicrobial peptide. We present in vivo data showing that Aβ expression protects against fung
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1e1b18484ca9b9b43e6c5d52d3d3f5
https://pubmed.ncbi.nlm.nih.gov/27573123
https://pubmed.ncbi.nlm.nih.gov/27573123
Autor:
Kevin J. Washicosky, Michael A. Myre, Rudolph E. Tanzi, Wilma Wasco, Robert D. Moir, Giuseppina Tesco
Publikováno v:
Cellular Signalling. 21:567-576
The detection of cell cycle proteins in Alzheimer's disease (AD) brains may represent an early event leading to neurodegeneration. To identify cell cycle modifiers with anti-Abeta properties, we assessed the effect of Differentiation-Inducing Factor-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8380609cf61e55c62d6a772b61efa90b
https://doi.org/10.1016/j.cellsig.2008.12.008
https://doi.org/10.1016/j.cellsig.2008.12.008