Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Kevin J. Volk"'
Autor:
Xiaoni Liu, Frank LaCreta, David W. Boulton, Ravindra W. Tejwani, Carey Hines, Steven C. Griffen, Kevin J. Volk, Charles Smith
Publikováno v:
International Journal of Pharmaceutics. 511:288-295
Physical storage of formulations may result in physical composition changes that affect pharmacokinetics. Dapagliflozin, an oral sodium-glucose cotransporter 2 inhibitor used for type 2 diabetes mellitus, stored under prolonged exposure to heat conve
Autor:
Mayra B. Reyes, Simon Leung, Zenrong Gao, Theo Denzel, Chiajen Lai, Jack Z. Gougoutas, Mark Lindrud, Kevin J. Volk, Thomas P. Kissick, Victor W. Rosso, Gerard A. Crispino, Wei Meng, Pricilla Richberg, Prashant P. Deshpande, William N. Washburn, Mueller Richard H, David Hughes, Hidegard Lobinger, Renee Randazzo, Peter Hans Ermann, Michael E. Randazzo, Wendel W. Doubleday, Michael Fakes, Annie Pullockaran, Frederic G. Buono, Bruce A. Ellsworth, Janak Singh, John D. Dimarco
Publikováno v:
Organic Process Research & Development. 16:577-585
A practical synthesis of the SGLT-2 inhibitor β-C-aryl-d-glucoside (1) has been developed. The route employed 2,3,4,6-tetra-O-trimethlysilyl-d-glucano-1,5-lactone as the key chiral building block, prepared efficiently from the commercially available
Autor:
Saul W. Fink, Kumar Penmetsa, Christopher D. Reddick, Gerald C. DiDonato, Brent Kleintop, Kevin J. Volk, Steven E. Klohr
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 23:831-839
The majority of chiral HPLC separations are performed in the normal-phase mode using alcohol-modified hexane mobile phases. Normal-phase chiral HPLC methods are not routinely coupled with electrosp...
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 20:115-128
A method has been developed for the real-time analysis of components in in vitro reactions by the on-line combination of microdialysis sampling (MD) with tandem mass spectrometry (MS/MS) and single stage mass spectrometry (MS). Apparatus and paramete
Autor:
Byron H. Long, Joan M. Carboni, Susan E. Hill, Kevin J. Volk, Mike S. Lee, David J. Detlefsen, Edward H. Kerns
Publikováno v:
Rapid Communications in Mass Spectrometry. 12:620-624
A new method for studying cellular uptake has been developed. This method is based on selected reaction monitoring liquid chromatography tandem mass spectrometry analysis of preparations from cell culture. The limit of detection for paclitaxel was ap
Publikováno v:
Drug Information Journal. 32:471-485
The chemical identification of botanical products can be accomplished by obtaining a “profile “ of the mixture components. Changes in this profile are powerful indicators of variations due to such factors as process differences, raw material sour
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 698:133-145
A rapid and systematic LC-MS protocol is utilized to profile buspirone metabolites. Analysis of rat bile, urine and liver S9 samples using a standard LC-MS method provides structural information for 25 metabolites. The resulting buspirone metabolite
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 15:1729-1739
Analysis of the antitumor agent Paclitaxel, related taxane analogues and yew tree bark extracts has been carried out using an HPLC system capable of performing chromatographic separations with conventional, small-bore, and micro-bore columns. Both di
Autor:
Edward H. Kerns, Daniel R. Schroeder, John E. Leet, Kevin J. Volk, Steven E. Klohr, Ira E. Rosenberg, Mike S. Lee
Publikováno v:
Journal of Mass Spectrometry. 31:1253-1260
Structure identification strategies for kedarcidin chromophore are described using tandem mass spectrometry (MS/MS) and high-resolution MS techniques. The strategy involves dividing a large, complex natural product molecule into several smaller molec
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 14:1663-1674
A rapid and systemic strategy based on liquid chromatography/mass spectrometry (LC/MS) profiling and liquid chromatography/tandem mass spectrometry (LC/MS/MS) substructural techniques was utilized to elucidate the degradation products of butorphanol,