Zobrazeno 1 - 10
of 250
pro vyhledávání: '"Kevin J. Verstrepen"'
Autor:
Michiel Schreurs, Supinya Piampongsant, Miguel Roncoroni, Lloyd Cool, Beatriz Herrera-Malaver, Christophe Vanderaa, Florian A. Theßeling, Łukasz Kreft, Alexander Botzki, Philippe Malcorps, Luk Daenen, Tom Wenseleers, Kevin J. Verstrepen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The perception and appreciation of food flavor depends on many interacting chemical compounds and external factors, and therefore proves challenging to understand and predict. Here, we combine extensive chemical and sensory analyses of 250 d
Externí odkaz:
https://doaj.org/article/d2d89c0724ef4f819eb633b474382d64
Autor:
Charlotte Cautereels, Jolien Smets, Peter Bircham, Dries De Ruysscher, Anna Zimmermann, Peter De Rijk, Jan Steensels, Anton Gorkovskiy, Joleen Masschelein, Kevin J. Verstrepen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Microbes are increasingly employed as cell factories to produce biomolecules. This often involves the expression of complex heterologous biosynthesis pathways in host strains. Achieving maximal product yields and avoiding build-up of (toxic)
Externí odkaz:
https://doaj.org/article/a9a3bd487d6a49dbb67d4a79f704b03b
Autor:
Charlotte Cautereels, Jolien Smets, Jonas De Saeger, Lloyd Cool, Yanmei Zhu, Anna Zimmermann, Jan Steensels, Anton Gorkovskiy, Thomas B. Jacobs, Kevin J. Verstrepen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Site-specific recombinases such as the Cre-LoxP system are routinely used for genome engineering in both prokaryotes and eukaryotes. Importantly, recombinases complement the CRISPR-Cas toolbox and provide the additional benefit of high-effic
Externí odkaz:
https://doaj.org/article/10f52b4d37ae408a90cf7fc42e8a0d62
Autor:
Leonardo G. Kretzer, Marilia M. Knychala, Lucca C. da Silva, Isadora C. C. da Fontoura, Maria José Leandro, César Fonseca, Kevin J. Verstrepen, Boris U. Stambuk
Publikováno v:
Fermentation, Vol 10, Iss 9, p 490 (2024)
Developing recombinant Saccharomyces cerevisiae strains capable of transporting and fermenting cellobiose directly is a promising strategy for second-generation ethanol production from lignocellulosic biomass. In this study, we cloned and expressed i
Externí odkaz:
https://doaj.org/article/963cc7d5cd6144289fc379bd0a5fbf0c
Publikováno v:
Cancers, Vol 16, Iss 11, p 1959 (2024)
Photon-based radiotherapy (XRT) is one of the most frequently used treatment modalities for HPV-negative and HPV-positive locally advanced head and neck squamous cell carcinoma (HNSCC). However, locoregional recurrences and normal RT-associated toxic
Externí odkaz:
https://doaj.org/article/2a971855bc694f74b6aa28a6271c2b9b
Autor:
Anna Zimmermann, Julian E. Prieto-Vivas, Charlotte Cautereels, Anton Gorkovskiy, Jan Steensels, Yves Van de Peer, Kevin J. Verstrepen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The generation of genetic diversity via mutagenesis is routinely used for protein engineering and pathway optimization. Current technologies for random mutagenesis often target either the whole genome or relatively narrow windows. To bridge
Externí odkaz:
https://doaj.org/article/4ba11ca207744a24851d08085ba157b2
Autor:
Lore Hoes, Karin Voordeckers, Rüveyda Dok, Bram Boeckx, Bart Steemans, Diyavarshini Gopaul, Philippe Pasero, Sander K. Govers, Diether Lambrechts, Sandra Nuyts, Kevin J. Verstrepen
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108564- (2023)
Summary: Although ethanol is a class I carcinogen and is linked to more than 700,000 cancer incidences, a clear understanding of the molecular mechanisms underlying ethanol-related carcinogenesis is still lacking. Further understanding of ethanol-rel
Externí odkaz:
https://doaj.org/article/0e67321dbe894fed9ba67aa20c841807
Autor:
Ping-Wei Ho, Supinya Piampongsant, Brigida Gallone, Andrea Del Cortona, Pieter-Jan Peeters, Frank Reijbroek, Jules Verbaet, Beatriz Herrera, Jeroen Cortebeeck, Robbe Nolmans, Veerle Saels, Jan Steensels, Daniel F. Jarosz, Kevin J. Verstrepen
Publikováno v:
Biotechnology for Biofuels, Vol 14, Iss 1, Pp 1-18 (2021)
Abstract Background The brewer’s yeast Saccharomyces cerevisiae is exploited in several industrial processes, ranging from food and beverage fermentation to the production of biofuels, pharmaceuticals and complex chemicals. The large genetic and ph
Externí odkaz:
https://doaj.org/article/26a80d9fab4e47b38ee03e7ef549f1a3
Autor:
Lieselotte Vermeersch, Lloyd Cool, Anton Gorkovskiy, Karin Voordeckers, Tom Wenseleers, Kevin J. Verstrepen
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Microbes are constantly confronted with changes and challenges in their environment. A proper response to these environmental cues is needed for optimal cellular functioning and fitness. Interestingly, past exposure to environmental cues can accelera
Externí odkaz:
https://doaj.org/article/46ca85238f43442bb9059e98245b35ca
Autor:
Karin Voordeckers, Camilla Colding, Lavinia Grasso, Benjamin Pardo, Lore Hoes, Jacek Kominek, Kim Gielens, Kaat Dekoster, Jonathan Gordon, Elisa Van der Zande, Peter Bircham, Toon Swings, Jan Michiels, Peter Van Loo, Sandra Nuyts, Philippe Pasero, Michael Lisby, Kevin J. Verstrepen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Whereas the toxic effects of ethanol are well-documented, the underlying mechanism is obscure. This study uses the eukaryotic model S. cerevisiae to reveal how exposure to sublethal ethanol concentrations causes DNA replication stress and an increase
Externí odkaz:
https://doaj.org/article/df587fed078742dfbc9ad32716f400df