Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kevin J. Trouba"'
Autor:
Marc H. Davies, Wenying Li, Jae Kwagh, Michael J. Graziano, Yongxin Zhu, C. W. Storck, Jian Wang, Kevin J Trouba, William G. Humphreys, Thomas P. Sanderson, Ang Liu, Li Ma, Oliver P. Flint, Bonnie Wang
Publikováno v:
International Journal of Toxicology. 36:35-49
BMS-986094, a 2′-C-methylguanosine prodrug for the treatment of chronic hepatitis C virus infection, was withdrawn from phase 2 clinical trials because of unexpected cardiac and renal toxicities. To better understand these toxicities, the in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7b63992db0a081bfb9f91d2d2851ccb
https://doi.org/10.1177/1091581816683642
https://doi.org/10.1177/1091581816683642
Autor:
John Lute, Bonnie Wang, Jian Wang, Kevin J Trouba, Ang Liu, Anne-Françoise Aubry, Huidong Gu, Mark E. Arnold
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1000
BMS-986094, a nucleotide polymerase inhibitor of the hepatitis C virus, was withdrawn from clinical trials because of a serious safety issue. To investigate a potential association between drug/metabolite exposure and toxicity in evaluations conducte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159ed7c5dddfe1a6385c66e6eb50b56d
https://pubmed.ncbi.nlm.nih.gov/26209768
https://pubmed.ncbi.nlm.nih.gov/26209768
Publikováno v:
Environmental Health Perspectives
Previous research demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment increased the number of skin papillomas in v-Ha-ras transgenic (Tg.AC) mice that had received sodium arsenite [(As(III)] in drinking water, indicating that this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18babb61f70db47c5d0a567e840a7ed2
https://doi.org/10.1289/txg.7152
https://doi.org/10.1289/txg.7152
Autor:
Kevin J Trouba, Yue Zhao, Jim X Shen, Mark E. Arnold, Lora Hamuro, Guowen Liu, Binodh DeSilva, Bonnie Wang, Aida Angeles, Renuka Pillutla
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 988
We have developed and fully validated a fast and simple LC-MS/MS assay to quantitate a therapeutic protein BMS-A in cynomolgus monkey serum. Prior to trypsin digestion, a recently reported sample pretreatment method was applied to remove more than 95
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7665750e44697bde83adf4d29e36a19a
https://pubmed.ncbi.nlm.nih.gov/25756208
https://pubmed.ncbi.nlm.nih.gov/25756208
Autor:
Anne-Françoise Aubry, Shenita Basdeo, Qin C Ji, Jianing Zeng, Qianping Peng, Naiyu Zheng, Aida Angeles, Adela Buzescu, Laura Patrone, Mark E. Arnold, Kevin J Trouba
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 89
An UHPLC-MS/MS method was developed and validated to quantify BMS-927711, a drug candidate to treat migraine, in rat dried blood spots (DBS). The DBS samples were extracted using an improved liquid-liquid extraction (LLE) strategy involving in the so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9841ed97c01e4ec8c5d0e7afe741748
https://pubmed.ncbi.nlm.nih.gov/24316424
https://pubmed.ncbi.nlm.nih.gov/24316424
Autor:
Mark E. Arnold, Billy Akinsanya, Anne-Françoise Aubry, Adela Buzescu, Van T. Ly, Naiyu Zheng, Kevin J Trouba, Qianping Peng, Jianing Zeng, Yuan-Qing Xia
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 83
BMS-927711 is a calcitonin gene-related peptide (CGRP) receptor antagonist that is being developed for the treatment of migraine. A rapid, accurate and robust assay was developed and validated for the quantitation of BMS-927711 in rat, monkey, rabbit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ed6b5046f40c78ca20a782a0d675e1
https://pubmed.ncbi.nlm.nih.gov/23770636
https://pubmed.ncbi.nlm.nih.gov/23770636
Publikováno v:
Cancer Letters. 109:211-215
GAP is a key negative regulator of the receptor tyrosine kinase (RTK) signal transduction pathway. The purpose of this study was to determine if expression or activity of GAP is modulated by hyperstimulation of the RTK pathway. It was found that cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::623688ace434a3440adb5e202d8e76be
https://doi.org/10.1016/s0304-3835(96)04456-4
https://doi.org/10.1016/s0304-3835(96)04456-4
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 117(2)
This study was conducted to assess the safety and tolerability of the alternative formulation vehicles polysorbate 80 (PS80), propylene glycol (PG), and hydroxypropyl-beta-cyclodextrin (HPβCD) in general toxicology studies in the mouse, rat, dog, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::332c1ee28cac3dcdb05fd63c4fc3bc66
https://pubmed.ncbi.nlm.nih.gov/20643750
https://pubmed.ncbi.nlm.nih.gov/20643750
Publikováno v:
Immunotoxicology and Immunopharmacology, Third Edition ISBN: 9780849337901
Immunotoxicology and Immunopharmacology, Third Edition
Immunotoxicology and Immunopharmacology, Third Edition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f3cdd741834d2f9d1d4814427d92396
https://doi.org/10.1201/9781420005448.ch16
https://doi.org/10.1201/9781420005448.ch16
Autor:
David B. Dunson, Abraham Nyska, G. Moser, Miroslav Styblo, A. Suttie, Rachel M. Patterson, S. Grossman, Dori R. Germolec, Kevin J. Trouba, L. Lomnitski, F. Walton
Publisher Summary Arsenic (As) is a human carcinogen and its exposure via drinking water is linked to skin cancer, hyperkeratosis, and pigmentation abnormalities. Epidemiological studies indicate that inorganic arsenicals produce various skin lesions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edeb86841b401aee92320bd09aa6fdb2
https://doi.org/10.1016/b978-044451441-7/50022-1
https://doi.org/10.1016/b978-044451441-7/50022-1