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High-throughput single-molecule quantification of individual base stacking energies in nucleic acids
Autor:
Jibin Abraham Punnoose, Kevin J. Thomas, Arun Richard Chandrasekaran, Javier Vilcapoma, Andrew Hayden, Kacey Kilpatrick, Sweta Vangaveti, Alan Chen, Thomas Banco, Ken Halvorsen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
In this work, the authors use a centrifuge force microscope for high-throughput single-molecule experiments to elucidate stacking energies between individual bases of DNA.
Externí odkaz:
https://doaj.org/article/ef0ecd059a474bb888ca39c3aacfb9e0
High-throughput single-molecule quantification of individual base stacking energies in nucleic acids
Autor:
Jibin Abraham Punnoose, Kevin J. Thomas, Arun Richard Chandrasekaran, Javier Vilcapoma, Andrew Hayden, Kacey Kilpatrick, Sweta Vangaveti, Alan Chen, Thomas Banco, Ken Halvorsen
Base stacking interactions between adjacent bases in DNA and RNA are known to be important for many biological processes, for drug development, and in other biotechnology applications. While previous work has estimated base stacking energies between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bafb8216d40ded5bc6efac7d72b070c
https://doi.org/10.1101/2022.05.25.493108
https://doi.org/10.1101/2022.05.25.493108
Publikováno v:
Biophysical Journal. 121:284a
Autor:
Kevin J. Thomas, James Evans
Publikováno v:
AAPG Bulletin. 85
Publikováno v:
BMJ. 333:0607280
A woman aged 52, otherwise fit and well, was admitted as an emergency with the history of a sudden onset constant back pain on the right hand side, for the past four hours. On examination her vital signs were blood pressure: 130/78 mm Hg; pulse 80/mi