Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Kevin J. Scanlon"'
Publikováno v:
Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::854c4dcec7a8740970bbd5f4284ce769
https://doi.org/10.1201/9781003064657-15
https://doi.org/10.1201/9781003064657-15
This book is a collection of preclinical and clinical reports on the application of gene therapy to human disease. The two methods available for delivering therapeutic genes to diseased cells, viral and non-viral vector systems, are detailed and char
Autor:
Shinji Goto, Hiroshi Kijima, Yoshito Ihara, Mikio Oka, Yoshishige Urata, Kevin J. Scanlon, Tetsuya Iida, Shigeru Kohno, Takahito Kondo
Publikováno v:
Cancer Gene Therapy. 8:803-814
Multidrug resistance in cancer cells is often associated with an elevation in the concentration of glutathione (GSH) and the expression of gamma-glutamylcysteine synthetase (gamma-GCS), a rate-limiting enzyme for GSH. We constructed a hammerhead ribo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0418a261c6b2bb7e376a57fd51aa886
https://doi.org/10.1038/sj.cgt.7700371
https://doi.org/10.1038/sj.cgt.7700371
Autor:
Masato Nakamura, Hitoshi Yamazaki, Kevin J. Scanlon, Hiroyuki Hatanaka, Satomi Asai, Yoshito Ueyama, Takeshi Miwa, Hiroshi Kijima, Junko Nagata, Hayato Miyachi, Tetsuya Mine, Atsushi Takagi, Takahito Kondo
Publikováno v:
Biochemical and Biophysical Research Communications. 286:406-413
gamma-Glutamylcysteine synthetase (gamma-GCS) is a key enzyme in glutathione (GSH) synthesis, and is thought to play a significant role in intracellular detoxification, especially of anticancer drugs. Increased levels of GSH are commonly found in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34556b7d265aab84cd76bcab0e570943
https://doi.org/10.1006/bbrc.2001.5399
https://doi.org/10.1006/bbrc.2001.5399
Autor:
Kevin J. Scanlon, T Tsuchida, Kenji Kawai, Tetsuji Tokunaga, M Nakamura, Norikazu Tamaoki, Y Ueyama, Sadaaki Hori, H Yamazaki, Hiroshi Kijima, Yoshiro Oshika
Publikováno v:
Cancer Gene Therapy. 7:373-383
Human pancreatic cancer is a lethal malignancy, and the lesions show a very high incidence of point mutations of the K-ras oncogene. These alterations can be used as potential targets for specific ribozyme (Rz)-mediated growth suppression of the canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae303fe31d3f969160e6688e5ad0e048
https://doi.org/10.1038/sj.cgt.7700136
https://doi.org/10.1038/sj.cgt.7700136
Autor:
David T. Curiel, Mohammed Kashani-Sabet, Kevin J. Scanlon, M. Halks-Miller, O. Engebraaten, Toshiya Suzuki, Tsukasa Ohkawa, B. Anderegg, Akira Irie, P. S. Holm
Publikováno v:
Gene Therapy. 7:241-248
HER-2/neu is overexpressed in 25-30% of human breast cancers. We prepared an anti-HER-2/neu hammerhead ribozyme expressed by a recombinant adenovirus (rAdHER-Rz). Human breast cancer cell lines were transduced with high efficiency, resulting in decre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9061ed941b3c4c0849123f44f8871fbb
https://doi.org/10.1038/sj.gt.3301065
https://doi.org/10.1038/sj.gt.3301065
Autor:
Kevin J. Scanlon, Toshiya Suzuki, Mohammed Kashani-Sabet, Akira Irie, Meredith Halks-Miller, Tsukasa Ohkawa, David T. Curiel, Birgit Anderegg
Publikováno v:
Antisense and Nucleic Acid Drug Development. 9:341-349
Ras oncogenes are thought to play a critical role in cellular proliferation and tumorigenesis. Reversal of the malignant phenotype, inhibition of tumor growth, and decreased tumorgenicity have been demonstrated with the use of anti-H-ras ribozymes. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f551352203b74ef2eb0c70f2bfe5652
https://doi.org/10.1089/oli.1.1999.9.341
https://doi.org/10.1089/oli.1.1999.9.341
Autor:
Takahito Kondo, Hiroshi Kijima, Yoshiro Oshika, Norikazu Tamaoki, Hideaki Kondo, Masato Nakamura, T Tsuchida, Kevin J. Scanlon, Tetsuya Iida
Publikováno v:
Biochemical and Biophysical Research Communications. 247:697-703
gamma-Glutamylcysteine synthetase (gamma-GCS) is a key enzyme in glutathione synthesis and is thought to play a significant role in intracellular detoxification systems. To specifically suppress gamma-GCS gene expression, we constructed two different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf9815490a54ba14bf6eea2c257a39b
https://doi.org/10.1006/bbrc.1998.8878
https://doi.org/10.1006/bbrc.1998.8878
Publikováno v:
Journal of Investigative Dermatology. 106:275-280
The activation of signal transduction pathways by mutation or overexpression of cellular oncogenes has been associated with neoplastic transformation. In this study, we addressed the therapeutic potential of ribozymes targeted against the activated H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e7fa339eecf1628d49ee7b7beca2a6
https://doi.org/10.1111/1523-1747.ep12340688
https://doi.org/10.1111/1523-1747.ep12340688
Publikováno v:
Oncology Research and Treatment. 19:19-22
Proto-oncogenes have been shown to play a critical role in cell growth and differentiation via signal transduction pathways. Oncogenes, either by enhanced gene expression or altered gene expression, c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aff5197934b9f6ef60127e95db40f703
https://doi.org/10.1159/000218882
https://doi.org/10.1159/000218882