Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Kevin J. Saliba"'
Autor:
Alexa Redway, Christina Spry, Ainka Brown, Ursula Wiedemann, Imam Fathoni, Larnelle F. Garnie, Deyun Qiu, Timothy J. Egan, Adele M. Lehane, Yvette Jackson, Kevin J. Saliba, Nadale Downer-Riley
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 25, Iss , Pp 100536- (2024)
Malaria continues to be a significant burden, particularly in Africa, which accounts for 95% of malaria deaths worldwide. Despite advances in malaria treatments, malaria eradication is hampered by insecticide and antimalarial drug resistance. Consequ
Externí odkaz:
https://doaj.org/article/7c9a9489f8234aad9bd8dd478692ccf0
Autor:
Vanessa M. Howieson, Joy Zeng, Joachim Kloehn, Christina Spry, Chiara Marchetti, Matteo Lunghi, Emmanuel Varesio, Andrew Soper, Anthony G. Coyne, Chris Abell, Giel G. van Dooren, Kevin J. Saliba
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 22, Iss , Pp 1-8 (2023)
Toxoplasma gondii is a pervasive apicomplexan parasite that can cause severe disease and death in immunocompromised individuals and the developing foetus. The treatment of toxoplasmosis often leads to serious side effects and novel drugs and drug tar
Externí odkaz:
https://doaj.org/article/00b024bbf99f4341a185721a0ef4505e
The Key Glycolytic Enzyme Phosphofructokinase Is Involved in Resistance to Antiplasmodial Glycosides
Autor:
Gillian M. Fisher, Simon A. Cobbold, Andrew Jezewski, Emma F. Carpenter, Megan Arnold, Annie N. Cowell, Erick T. Tjhin, Kevin J. Saliba, Tina S. Skinner-Adams, Marcus C. S. Lee, Audrey Odom John, Elizabeth A. Winzeler, Malcolm J. McConville, Sally-Ann Poulsen, Katherine T. Andrews
Publikováno v:
mBio, Vol 11, Iss 6 (2020)
ABSTRACT Plasmodium parasites rely heavily on glycolysis for ATP production and for precursors for essential anabolic pathways, such as the methylerythritol phosphate (MEP) pathway. Here, we show that mutations in the Plasmodium falciparum glycolytic
Externí odkaz:
https://doaj.org/article/610827e8ff5a4ac08e02462e0f5e26af
Autor:
Phuong N. Tran, Cameron J. Tate, Melanie C. Ridgway, Kevin J. Saliba, Kiaran Kirk, Alexander G. Maier
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 6, Iss 3, Pp 179-183 (2016)
Ketotifen has recently been reported to inhibit the growth of both asexual and sexual malaria parasites. A parasite transporter, PfgABCG2, has been implicated in its mechanism of action. Human dihydrofolate reductase (hDHFR) is the most commonly used
Externí odkaz:
https://doaj.org/article/bca708d4dc524a98acefd1eb8a9cff69
Autor:
Sabine Fletcher, Leonardo Lucantoni, Melissa L. Sykes, Amy J. Jones, John P. Holleran, Kevin J. Saliba, Vicky M. Avery
Publikováno v:
Parasites & Vectors, Vol 9, Iss 1, Pp 1-13 (2016)
Abstract Background In the fight against malaria, the discovery of chemical compounds with a novel mode of action and/or chemistry distinct from currently used drugs is vital to counteract the parasite’s known ability to develop drug resistance. An
Externí odkaz:
https://doaj.org/article/62bf9a4e1dc84e1eb1c8f9ff9c11a61a
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 963-968 (2016)
Pantothenamides are known for their in vitro antimicrobial activity. Our group has previously reported a new stereoselective route to access derivatives modified at the geminal dimethyl moiety. This route however fails in the addition of large substi
Externí odkaz:
https://doaj.org/article/dbcf183f61cc4d72b14659b3a1196afe
Autor:
Alex H. Y. Chan, Terence C. S. Ho, Imam Fathoni, Rebecca Pope, Kevin J. Saliba, Finian J. Leeper
Thiamine is metabolized into the coenzyme thiamine diphosphate (ThDP). Interrupting thiamine utilization leads to disease states. Oxythiamine, a thiamine analogue, is metabolized into oxythiamine diphosphate (OxThDP), which inhibits ThDP-dependent en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60186541de4b0b017c0b610042a5eb01
https://www.repository.cam.ac.uk/handle/1810/350318
https://www.repository.cam.ac.uk/handle/1810/350318
Publikováno v:
Antimicrob Agents Chemother
The ability of the human malaria parasite Plasmodium falciparum to access and utilize vital nutrients is critical to its growth and proliferation. Molecules that interfere with these processes could potentially serve as antimalarials. We found that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3b8dd5bb47bf38d25b29d4f15b4bbddd
https://pubmed.ncbi.nlm.nih.gov/36094195
https://pubmed.ncbi.nlm.nih.gov/36094195
Autor:
Alex H. Y. Chan, Terence C. S. Ho, Imam Fathoni, Rebecca Pope, Kevin J. Saliba, Finian James Leeper
Thiamine (vitamin B1) is metabolised into the coenzyme thiamine diphosphate (ThDP). Interrupting thiamine-utilisation leads to disease states and thiamine/ThDP analogues are commonly used as antagonists of thiamine-utilisation pathways to investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f71f396327cacf38d0376bf285621c26
https://doi.org/10.26434/chemrxiv-2023-5qgth
https://doi.org/10.26434/chemrxiv-2023-5qgth
A series of derivatives of a triazole analogue of thiamine has been synthesised. When tested as inhibitors of porcine pyruvate dehydrogenase, the benzoyl ester derivatives proved to be potent thiamine pyrophosphate (TPP) competitive inhibitors, with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e0299bdf48605edea5f024541480c2
https://www.repository.cam.ac.uk/handle/1810/340736
https://www.repository.cam.ac.uk/handle/1810/340736