Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kevin J. Pawlak"'
Autor:
Manoj Prasad, Maheshinie Rajapaksha, Brendan Marshall, Himangshu S. Bose, Elizabeth W Perry, Kevin J. Pawlak, Randy M. Whittal, Jasmeet Kaur
Publikováno v:
Molecular and Cellular Biology. 36:1032-1047
After cholesterol is transported into the mitochondria of steroidogenic tissues, the first steroid, pregnenolone, is synthesized in adrenal and gonadal tissues to initiate steroid synthesis by catalyzing the conversion of pregnenolone to progesterone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41388fcaabfb2ff77bb81e1a1b9bece9
https://doi.org/10.1128/mcb.01107-15
https://doi.org/10.1128/mcb.01107-15
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 155:166-176
Previous studies have shown that breast tissues and breast cell lines can convert progesterone to 5α-pregnane-3,20-dione (5aP), and that 5αP stimulates breast cell proliferation and detachment in vitro, and tumor formation in vivo, regardless of pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d24f8a3d82b34d406aa67194a2d506
https://doi.org/10.1016/j.jsbmb.2015.10.021
https://doi.org/10.1016/j.jsbmb.2015.10.021
Autor:
Himangshu S. Bose, Manoj Prasad, Elizabeth E. Perry, Brendan Marshall, William E Burak, Randy M. Whittal, Kevin J. Pawlak
Publikováno v:
Science Advances
ER chaperone GRP78 is the central regulator of adrenals and gonadal steroid synthesis for mammalian survival.
Steroids, essential for mammalian survival, are initiated by cholesterol transport by steroidogenic acute regulatory protein (StAR). Ap
Steroids, essential for mammalian survival, are initiated by cholesterol transport by steroidogenic acute regulatory protein (StAR). Ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6699c0661b5df619c617c01b125ed0
https://doi.org/10.1126/sciadv.1602038
https://doi.org/10.1126/sciadv.1602038
Publikováno v:
Journal of Biological Chemistry. 286:39130-39140
In the adrenals, testes, and ovaries, 3β-hydroxysteroid dehydrogenase type 2 (3βHSD2) catalyzes the conversion of pregnenolone to progesterone and dehydroepiandrostenedione to androstenedione. Alterations in this pathway can have deleterious effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b545e2af90d7f5d8396cb4ec834564
https://doi.org/10.1074/jbc.m111.290031
https://doi.org/10.1074/jbc.m111.290031
Autor:
Himangshu S. Bose, John P. Wiebe, Kevin J. Pawlak, C. Gary Gairola, Kevin A. McKenzie, Manoj Prasad, Randy M. Whittal
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 338:598-604
Steroidogenic acute regulatory protein facilitates the translocation of cholesterol to the inner mitochondrial membrane, thereby initiating steroidogenesis. At the inner mitochondrial membrane, cytochrome P450 side-chain cleavage enzyme converts chol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d5ab5870818509c3dd29508e561ead
https://doi.org/10.1124/jpet.111.182634
https://doi.org/10.1124/jpet.111.182634
Autor:
Mahuya Bose, Randy M. Whittal, Kevin J. Pawlak, Himangshu S. Bose, Manoj Prasad, Jasmeet Kaur
Publikováno v:
The Journal of biological chemistry. 290(5)
Steroid hormones are essential for carbohydrate metabolism, stress management, and reproduction and are synthesized from cholesterol in mitochondria of adrenal glands and gonads/ovaries. In acute stress or hormonal stimulation, steroidogenic acute re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d732ceb15f1c10b344e1e06d66776f2
https://pubmed.ncbi.nlm.nih.gov/25505173
https://pubmed.ncbi.nlm.nih.gov/25505173