Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Kevin J. Maloy"'
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Chronic inflammation contributes to tumor initiation in colitis-associated colorectal cancer (CRC). Indeed, inflammatory bowel disease (IBD) patients show an increased risk of developing CRC. Cancer immune evasion is a major issue in CRC and preclini
Externí odkaz:
https://doaj.org/article/dd25b7d075c64a45adc459dd7959d290
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
A controlled and self-limiting inflammatory reaction generally results in removal of the injurious agent and repair of the damaged tissue. However, in chronic inflammation, immune responses become dysregulated and prolonged, leading to tissue destruc
Externí odkaz:
https://doaj.org/article/cdfd990834e64ddc93835df504445a23
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Pattern recognition receptors (PRR), such as NOD-like receptors (NLRs), sense conserved microbial signatures, and host danger signals leading to the coordination of appropriate immune responses. Upon activation, a subset of NLR initiate the assembly
Externí odkaz:
https://doaj.org/article/225b73b2b669434caaa6ba706132badb
Autor:
Philip P. Ahern, Kevin J. Maloy
Publikováno v:
Immunology
The past two decades have seen an explosion in research that aims to understand how the dynamic interplay with the gut microbiota impacts host health and disease, establishing a role for the gut microbiota in a plethora of pathologies. Understanding
Autor:
Samuel C, Forster, Simon, Clare, Benjamin S, Beresford-Jones, Katherine, Harcourt, George, Notley, Mark D, Stares, Nitin, Kumar, Amelia T, Soderholm, Anne, Adoum, Hannah, Wong, Bélen, Morón, Cordelia, Brandt, Gordon, Dougan, David J, Adams, Kevin J, Maloy, Virginia A, Pedicord, Trevor D, Lawley
Publikováno v:
Nature microbiology. 7(4)
Experimental mouse models are central to basic biomedical research; however, variability exists across genetically identical mice and mouse facilities making comparisons difficult. Whether specific indigenous gut bacteria drive immunophenotypic varia
Autor:
Wong H, Virginia A. Pedicord, Cordelia Brandt, George Notley, Belén Morón, Simon Clare, A. Soderholm, Trevor D. Lawley, Katherine Harcourt, Mark D. Stares, David J. Adams, Anne T. Adoum, Beresford-Jones Bs, Nitin Kumar, Samuel C. Forster, Kevin J. Maloy, Gordon Dougan
The mammalian gut microbiota consists of hundreds of anaerobic bacterial species that shape intestinal homeostasis and influence host immune responses. Although the causal roles of specific human gut bacterial species in health and disease are emergi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06a6a729225bf261b5a07233a0841e75
https://doi.org/10.1101/2021.02.09.430393
https://doi.org/10.1101/2021.02.09.430393
Autor:
Nir Yogev, Tanja Bedke, Yasushi Kobayashi, Leonie Brockmann, Dominika Lukas, Tommy Regen, Andrew L. Croxford, Alexei Nikolav, Nadine Hövelmeyer, Esther von Stebut, Marco Prinz, Carles Ubeda, Kevin J. Maloy, Nicola Gagliani, Richard A. Flavell, Ari Waisman, Samuel Huber
Publikováno v:
Cell Reports. 38:110565
Publikováno v:
Immunology
Summary Intestinal epithelial cells (IECs) constitute the border between the vast antigen load present in the intestinal lumen and the mucosal immune compartment. Their ability to express antigen processing and presentation machinery evokes the quest
Autor:
Gustavo Caballero-Flores, Ricardo Gonçalves, Richardo Tostes Gazzinelli, Kevin J. Maloy, Thais Abdala Torres, Suelen Queiroz Diniz, Gabriel Núñez, Luara Isabela dos Santos, Lis Ribeiro do Valle Antonelli
Publikováno v:
Cell Reports
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Cell Reports, Vol 34, Iss 2, Pp 108613-(2021)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Cell Reports, Vol 34, Iss 2, Pp 108613-(2021)
Summary Individuals with malaria exhibit increased morbidity and mortality when infected with Gram-negative (Gr−) bacteria. To explore this experimentally, we performed co-infection of mice with Plasmodium chabaudi and Citrobacter rodentium, an ext
Autor:
Dhelio Batista Pereira, Pedro A C Costa, Lis Ribeiro do Valle Antonelli, Andréa Teixeira-Carvalho, Kevin J. Maloy, Maria Marta Figueiredo, Ana P M M Peixoto, Ricardo T. Gazzinelli, Mauro Shugiro Tada, Suelen Queiroz Diniz
Publikováno v:
The Journal of Infectious Diseases. 218:1314-1323
The balance between pro- and antiinflammatory mechanisms is essential to limit immune-mediated pathology, and CD4(+) forkhead box P3 (Foxp3(+)) regulatory T cells (Treg) play an important role in this process. The expression of inhibitory receptors r