Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kevin J. Knagge"'
Autor:
Baharan Fekry, Kristen A. Jeffries, Amin Esmaeilniakooshkghazi, Zdzislaw M. Szulc, Kevin J. Knagge, David R. Kirchner, David A. Horita, Sergey A. Krupenko, Natalia I. Krupenko
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Ceramides are important participants of signal transduction, regulating fundamental cellular processes. Here authors show that C16-ceramide binds to the tumor suppressor p53, disrupts its interaction with MDM2 and facilitates p53 accumulation and act
Externí odkaz:
https://doaj.org/article/c8bb01b97ed94da88a335f1f599d147e
Autor:
Dayami Lopez, Quantil M. Melendez, Catherine J. Wooten, Sreevidhya Krishnaji, David R. Kirchner, Kevin J. Knagge
Publikováno v:
International journal of biomedical investigation
High levels of cholesterol, especially as low-density lipoprotein (LDL), are a well-known risk factor for atherosclerotic-related diseases. The key atherogenic property of LDL is its ability to form atherosclerotic plaque. Proprotein convertase subti
Autor:
Natalia I. Krupenko, Sergey A. Krupenko, Kevin J. Knagge, David R. Kirchner, Baharan Fekry, Zdzislaw M. Szulc, Amin Esmaeilniakooshkghazi, David A. Horita, Kristen A. Jeffries
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Ceramides are important participants of signal transduction, regulating fundamental cellular processes. Here we report the mechanism for activation of p53 tumor suppressor by C16-ceramide. C16-ceramide tightly binds within the p53 DNA-binding domain
Publikováno v:
Brain, Behavior, and Immunity. 56:246-252
This study utilized a pro-inflammatory exercise mode to explore potential linkages between increases in 9- and 13-hydroxy-octadecadienoic acid (9+13 HODE) and biomarkers for inflammation, oxidative stress, and muscle damage. Male (N=10) and female (N
Autor:
Steven D. Colman, Xiang Zhang, Xiaoli Wei, Kevin J. Knagge, Simon G. Gregory, Jason H. Winnike
Publikováno v:
Journal of proteome research. 14(4)
We compared the performance of gas chromatography time-of-flight mass spectrometry (GC-MS) and comprehensive two-dimensional gas chromatography mass spectrometry (GC×GC-MS) for metabolite biomarker discovery. Metabolite extracts from 109 human serum
Autor:
Harry E. Ensley, Michael D. Kruppa, David L. Williams, Kevin J. Knagge, Douglas W. Lowman, Rachel R. Greene
Publikováno v:
Carbohydrate Research.
The Candida albicans cell wall provides an architecture that allows for the organism to survive environmental stress as well as interaction with host tissues. Previous work has focused on growing C. albicans on media such as Sabouraud or YPD at 30 °