Viability-PCR Shows That NAAT Detects a High Proportion of DNA from Non-Viable Chlamydia trachomatis.

Autor: Kevin J H Janssen, Christian J P A Hoebe, Nicole H T M Dukers-Muijrers, Lisanne Eppings, Mayk Lucchesi, Petra F G Wolffs

Publikováno v: PLoS ONE, Vol 11, Iss 11, p e0165920 (2016)

According to the current guidelines for laboratory diagnosis of sexually transmitted infections (STIs), nucleic acid amplification tests (NAATs) are the preferred diagnostic method for Chlamydia trachomatis (CT) infections. However, NAATs amplify the

Externí odkaz: https://doaj.org/article/d5ff26a75a764c2eb7faca67974b644b

Determinants associated with viable genital or rectal Chlamydia trachomatis bacterial load (FemCure)

Autor: Hannelore M Götz, Kevin J. H. Janssen, Petra F. G. Wolffs, Maarten F. Schim van der Loeff, Nicole H. T. M. Dukers-Muijrers, Christian J. P. A. Hoebe, Sylvia M. Bruisten, Henry J. C. de Vries, Titia Heijman

Publikováno v: Sexually Transmitted Infections, 98(1), 17-22. BMJ Publishing Group

BackgroundChlamydia trachomatis (CT) is routinely diagnosed by nucleic acid amplification tests (NAATs), which are unable to distinguish between nucleic acids from viable and non-viable CT organisms.ObjectivesWe applied our recently developed sensiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c438f38cd365fcdd18678ec5a71da9
https://pure.eur.nl/en/publications/6043c440-2de7-44e6-9c82-d9a9742a39a6

Determinants associated with viable genital or rectal

Autor: Kevin J H, Janssen, Petra F G, Wolffs, Christian J P A, Hoebe, Titia, Heijman, Hannelore M, Götz, Sylvia M, Bruisten, Maarten, Schim van der Loeff, Henry J, de Vries, Nicole H T M, Dukers-Muijrers

Publikováno v: Sexually transmitted infections. 98(1)

We applied our recently developed sensitive PCR (viability PCR) technique to measure viable bacterial CT load and explore associated determinants in 524 women attending Dutch sexual health centres (STI clinics), and who had genital or rectal CT.We in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::efaee62ac72260288ebdd91b93c44102
https://pubmed.ncbi.nlm.nih.gov/33441449

Assessment of rectal

Autor: Kevin J H, Janssen, Petra, Wolffs, Mayk, Lucchesi, Nicole H T M, Dukers-Muijrers, Christian J P A, Hoebe

Publikováno v: Sexually transmitted infections. 96(2)

In recent years, studies have demonstrated frequent rectalIn this cross-sectional explorative study, a convenience sample of female patients at our STI clinic aged 18 years or older, diagnosed with vaginal and/or rectal CT, were invited to participat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7ded9e20241c2ec1fd524d472063284d
https://pubmed.ncbi.nlm.nih.gov/31383780

Viable Bacterial Load Is Key to Azithromycin Treatment Failure in Rectally Chlamydia trachomatis Infected Women (FemCure)

Autor: Nicole H. T. M. Dukers-Muijrers, Petra F. G. Wolffs, Christian J. P. A. Hoebe, Kevin J. H. Janssen, Henry J C de Vries, Hannelore M Götz

Publikováno v: Journal of Infectious Diseases, 220(8), 1389-1390. Oxford University Press
J Infect Dis
Journal of infectious diseases, 220(8), 1389-1390. Oxford University Press

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c26263292a4fdb5aa0b050fca2eab7cd
https://doi.org/10.1093/infdis/jiz267