Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Kevin J. Gingrich"'
Autor:
Richard L. Wang, Kevin J. Gingrich, Awais Vance, Mark D. Johnson, Babu G. Welch, David L. McDonagh
Publikováno v:
Journal of Stroke and Cerebrovascular Diseases. 32:107056
Publikováno v:
Simulation in healthcare : journal of the Society for Simulation in Healthcare. 15(1)
STATEMENT Psychological stress arises from a stressor placed on an individual that leads to both emotional and physiological responses. The latter is referred to as psychophysiological stress. Healthcare simulation provides a platform to investigate
Publikováno v:
Journal of General Physiology. 149:623-638
Voltage-gated Na + channels (Na v ) have emerged as important presynaptic targets for volatile anesthetic (VA) effects on synaptic transmission. However, the detailed biophysical mechanisms by which VAs modulate Na v function remain unclear. VAs alte
Autor:
Kevin J. Gingrich, Larry E. Wagner
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1858:1175-1188
Local anesthetics (LAs) block resting, open, and inactivated states of voltage-gated Na(+) channels where inactivated states are thought to bind with highest affinity. However, reports of fast-onset block occurring over milliseconds hint at high-affi
Publikováno v:
British Journal of Anaesthesia. 115:112-121
The mechanisms by which volatile anaesthetics such as isoflurane alter neuronal function are poorly understood, in particular their presynaptic mechanisms. Presynaptic voltage-gated sodium channels (Na(v)) have been implicated as a target for anaesth
Publikováno v:
The Journal of General Physiology
The pharmacological effects of inhaled anesthetics on ion channel function are poorly understood. Sand et al. analyze macroscopic gating of the prokaryotic voltage-gated sodium channel, NaChBac, using a six-state kinetic scheme and demonstrate that i
Publikováno v:
The Journal of General Physiology
Millimolar concentrations of the barbiturate pentobarbital (PB) activate gamma-aminobutyric acid (GABA) type A receptors (GABARs) and cause blockade reported by a paradoxical current increase or "tail" upon washout. To explore the mechanism of blocka
Autor:
Kevin J. Gingrich, Lois E. McCarthy, Michelle E. Ehrlich, Michelle Niculescu, Paolo Mannelli, Ellen M. Unterwald
Publikováno v:
Neurotoxicology and Teratology. 26:839-848
Few studies have examined the influence of the age and the strain of mouse on the pharmacokinetics of psychostimulants, or the role of pharmacokinetics in age-related differences in drug responses. The present study compared concentrations of cocaine
Publikováno v:
Comprehensive Physiology
The sections in this article are: 1 Calcium Channels 2 Sodium Channels 2.1 Primary Structure of the Voltage-Gated Na+ Channel 2.2 Molecular Pharmacology of Na+ Channels 2.3 Molecular Pharmacology of an Inherited Disease 3 Potassium Channels 3.1 Volta
Publikováno v:
Anesthesiology. 95:1406-1413
Background The general anesthetic ketamine is known to be an N-methyl-D-aspartate receptor blocker. Although ketamine also blocks voltage-gated sodium channels in a local anesthetic-like fashion, little information exists on the molecular pharmacolog