Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Kevin J. Freedman"'
Autor:
Lauren S. Lastra, Y. M. Nuwan D. Y. Bandara, Michelle Nguyen, Nasim Farajpour, Kevin J. Freedman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Conductive events during nanopore sensing, are seen typically under low salt conditions and widely thought to arise from counterions brought into the pore via analyte. Here, authors show that an imbalance of ionic fluxes lead to conductive events.
Externí odkaz:
https://doaj.org/article/cf31fe2941a74e61b99688445c77934f
Publikováno v:
Frontiers in Nanotechnology, Vol 3 (2021)
Nanopore sensing is a promising tool well suited to capture and detect DNA and other single molecules. DNA is a negatively charged biomolecule that can be captured and translocated through a constricted nanopore aperture under an applied electric fie
Externí odkaz:
https://doaj.org/article/c3d6acee97054822842dbcdb264178af
Autor:
Kevin J. Freedman, Lauren M. Otto, Aleksandar P. Ivanov, Avijit Barik, Sang-Hyun Oh, Joshua B. Edel
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Nanopore sensors have shown tremendous potential for biomolecule sensing, though the diffusion-controlled capture can limit the speed of analysis. Here, the authors report a dielectrophoretic method to concentrate DNA near the tip of a nanopore, redu
Externí odkaz:
https://doaj.org/article/262317543d0c4b2896bf8cc7932ea005
Publikováno v:
Journal of the American Chemical Society. 144:3063-3073
Protein sequencing, as well as protein fingerprinting, has gained tremendous attention in the electrical sensing realm of solid-state nanopores and is challenging due to fast translocations and the use of high molar electrolytes. Despite providing an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339dc0cf1f105e19698a893867324661
https://doi.org/10.1021/jacs.1c11540
https://doi.org/10.1021/jacs.1c11540
The pervasive model for a solvated, ion-filled nanopore is often a resistor in parallel with a capacitor. Although the simple model suggests that ionic current can flow through both components, under voltage-clamped conditions, capacitive currentshou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1cbafb892330eb2cc5f0b6786f4ddb3
https://doi.org/10.1101/2022.10.20.513121
https://doi.org/10.1101/2022.10.20.513121
The gradual tapered geometry of nanopipettes offers a unique perspective on protein transport through nanopores since both a gradual and fast confinement is possible depending on translocation direction. Protein capture rate, unfolding, speed of tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::793a065b7246637d27f569ccb62b1506
https://doi.org/10.1101/2022.09.28.509929
https://doi.org/10.1101/2022.09.28.509929
Publikováno v:
ACS sensors. 7(7)
Nanopores are a promising single-molecule sensing device class that captures molecular-level information through resistive or conductive pulse sensing (RPS and CPS). The latter has not been routinely utilized in the nanopore field despite the benefit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886cadff079a61c89e585aadddb0ef6c
https://pubmed.ncbi.nlm.nih.gov/35707962
https://pubmed.ncbi.nlm.nih.gov/35707962
Autor:
Kevin J. Freedman, Vinay Sharma
Publikováno v:
Nano Letters. 21:3364-3371
Sensing via analyte passage through a constricted aperture is a powerful and robust technology which is being utilized broadly, from DNA sequencing to single virus and cell characterization. Micro- and nanoscale structures typically translocate a con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df708e1acca31c6740820ac9329e68e8
https://doi.org/10.1021/acs.nanolett.0c04392
https://doi.org/10.1021/acs.nanolett.0c04392
Publikováno v:
Small (Weinheim an der Bergstrasse, Germany). 18(16)
Nanopores are ideally suited for the analysis of long DNA fragments including chromosomal DNA and synthetic DNA with applications in genome sequencing and DNA data storage, respectively. Hydrodynamic fluid flow has been shown to slow down DNA transit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d28e5e9f72636e4cb1c4359d3de96fab
https://pubmed.ncbi.nlm.nih.gov/35266283
https://pubmed.ncbi.nlm.nih.gov/35266283
Autor:
Vinay Sharma, Kevin J. Freedman
Publikováno v:
ACS nano. 15(11)
Nanopore sensing has been widely used in applications ranging from DNA sequencing to disease diagnosis. To improve these capabilities, pressure-biased nanopores have been explored in the past to-primarily-increase the residence time of the analyte in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee60faf7aa4b4003210de98990f03e1c
https://pubmed.ncbi.nlm.nih.gov/34739757
https://pubmed.ncbi.nlm.nih.gov/34739757