Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Kevin J. Forsberg"'
Publikováno v:
Frontiers in Microbiology, Vol 4 (2013)
Rates of infection with antibiotic-resistant bacteria have increased precipitously over the past several decades, with far-reaching healthcare and societal costs. Recent evidence has established a link between antibiotic resistance genes in human pat
Externí odkaz:
https://doaj.org/article/1090531baaee430693943b1b01702801
Autor:
Yvette A Luyten, Deanna E Hausman, Juliana C Young, Lindsey A Doyle, Kerilyn M Higashi, Natalia C Ubilla-Rodriguez, Abigail R Lambert, Corina S Arroyo, Kevin J Forsberg, Richard D Morgan, Barry L Stoddard, Brett K Kaiser
Publikováno v:
Nucleic Acids Research. 50:5171-5190
Bacteriophage exclusion (‘BREX’) phage restriction systems are found in a wide range of bacteria. Various BREX systems encode unique combinations of proteins that usually include a site-specific methyltransferase; none appear to contain a nucleas
Autor:
Kevin J Forsberg, Ishan V Bhatt, Danica T Schmidtke, Kamyab Javanmardi, Kaylee E Dillard, Barry L Stoddard, Ilya J Finkelstein, Brett K Kaiser, Harmit S Malik
Publikováno v:
eLife, Vol 8 (2019)
CRISPR-Cas systems protect bacteria and archaea from phages and other mobile genetic elements, which use small anti-CRISPR (Acr) proteins to overcome CRISPR-Cas immunity. Because Acrs are challenging to identify, their natural diversity and impact on
Externí odkaz:
https://doaj.org/article/475c27cc0e5d46fe8d33c6b81749e41f
SUMMARYDNA-damaging agents are the pervasive inducers of temperate phages in model bacteria. However, most bacteria in the biosphere are predicted to carry multiple prophages, a state called polylysogeny, making it unclear how co-residing prophages c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e822a9dec87a22c4f3c3a5e58255ed8
Autor:
Kevin J. Forsberg
Publikováno v:
Journal of Molecular Biology. 435:167952
Autor:
Yvette A. Luyten, Deanna E. Hausman, Juliana C. Young, Lindsey A. Doyle, Kerilyn M. Higashi, Natalia C. Ubilla-Rodriquez, Abigail R. Lambert, Corina S. Arroyo, Kevin J. Forsberg, Richard D. Morgan, Barry L. Stoddard, Brett K. Kaiser
Bacteriophage exclusion (‘BREX’) phage restriction systems are found in a wide range of bacteria. Various BREX systems encode unique combinations of proteins that usually include a site-specific methyltransferase; none appear to contain a nucleas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7141c56cd3afbfea1ea625bc6cd19197
https://doi.org/10.1101/2021.12.19.473356
https://doi.org/10.1101/2021.12.19.473356
Autor:
Wantae Kim, Cynthia I Terrace, Kaylee E. Dillard, Ilya J. Finkelstein, Kevin J. Forsberg, Kamyab Javanmardi
Mobile genetic elements evade CRISPR-Cas adaptive immunity by encoding anti-CRISPR proteins (Acrs). Acrs inactivate CRISPR-Cas systems via diverse mechanisms but are generally specific for a narrow subset of Cas nucleases that share high sequence sim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e364a55cc441a02d7cbe5e632b6f7cd1
https://doi.org/10.1101/2021.09.15.460536
https://doi.org/10.1101/2021.09.15.460536
Autor:
Aimée M Moore, Sanket Patel, Kevin J Forsberg, Bin Wang, Gayle Bentley, Yasmin Razia, Xuan Qin, Phillip I Tarr, Gautam Dantas
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78822 (2013)
Emerging antibiotic resistance threatens human health. Gut microbes are an epidemiologically important reservoir of resistance genes (resistome), yet prior studies indicate that the true diversity of gut-associated resistomes has been underestimated.
Externí odkaz:
https://doaj.org/article/4a1286cfe91d4da1a184b55848864915
Autor:
Kevin J. Forsberg, Harmit S. Malik
Publikováno v:
Current Biology. 28:R361-R364
Bacteria protect themselves against infection using multiple defensive systems that move by horizontal gene transfer and accumulate in genomic 'defense islands'. A recent study exploited these features to uncover ten novel defense systems, substantia
Autor:
Barry L. Stoddard, Ruben V. Uribe, Rachel Werther, Brett K. Kaiser, Morten Otto Alexander Sommer, Danica T. Schmidtke, Deanna Hausman, Harmit S. Malik, Kevin J. Forsberg
Publikováno v:
PLoS Biology
Forsberg, K J, Schmidtke, D T, Werther, R, Uribe, R V, Hausman, D, Sommer, M O A, Stoddard, B L, Kaiser, B K & Malik, H S 2021, ' The novel anti-CRISPR AcrIIA22 relieves DNA torsion in target plasmids and impairs SpyCas9 activity ', PLOS Biology, vol. 19, no. 10, e3001428 . https://doi.org/10.1371/journal.pbio.3001428
PLoS Biology, Vol 19, Iss 10, p e3001428 (2021)
Forsberg, K J, Schmidtke, D T, Werther, R, Uribe, R V, Hausman, D, Sommer, M O A, Stoddard, B L, Kaiser, B K & Malik, H S 2021, ' The novel anti-CRISPR AcrIIA22 relieves DNA torsion in target plasmids and impairs SpyCas9 activity ', PLOS Biology, vol. 19, no. 10, e3001428 . https://doi.org/10.1371/journal.pbio.3001428
PLoS Biology, Vol 19, Iss 10, p e3001428 (2021)
To overcome CRISPR-Cas defense systems, many phages and mobile genetic elements (MGEs) encode CRISPR-Cas inhibitors called anti-CRISPRs (Acrs). Nearly all characterized Acrs directly bind Cas proteins to inactivate CRISPR immunity. Here, using functi