Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Kevin J. Bender"'
Autor:
Siavash Fazel Darbandi, Andrew D. Nelson, Emily Ling-lin Pai, Kevin J. Bender, John L. R. Rubenstein
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 14, Iss 1, Pp 1-11 (2022)
Abstract Background Tbr1 encodes a T-box transcription factor and is considered a high confidence autism spectrum disorder (ASD) gene. Tbr1 is expressed in the postmitotic excitatory neurons of the deep neocortical layers 5 and 6. Postnatally and neo
Externí odkaz:
https://doaj.org/article/84bffeb264cd437ea7a13c0b6e52968d
Autor:
Aliza T. Ehrlich, Pierre Couvineau, Selin Schamiloglu, Stefan Wojcik, Dillon Da Fonte, Amina Mezni, Mark von Zastrow, Kevin J. Bender, Michel Bouvier, Brigitte L. Kieffer
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Dopamine (DA) neurons are primarily concentrated in substantia nigra (SN) and ventral tegmental area (VTA). A subset of these neurons expresses the neurotensin receptor NTSR1 and its putative ligand neurotensin (Nts). NTSR1, a G protein-coupled recep
Externí odkaz:
https://doaj.org/article/60946e01acc54ad989070a28ad6aa5b1
Autor:
Lindsay Liang, Siavash Fazel Darbandi, Sirisha Pochareddy, Forrest O. Gulden, Michael C. Gilson, Brooke K. Sheppard, Atehsa Sahagun, Joon-Yong An, Donna M. Werling, John L. R. Rubenstein, Nenad Sestan, Kevin J. Bender, Stephan J. Sanders
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-14 (2021)
Abstract Background Genetic variants in the voltage-gated sodium channels SCN1A, SCN2A, SCN3A, and SCN8A are leading causes of epilepsy, developmental delay, and autism spectrum disorder. The mRNA splicing patterns of all four genes vary across devel
Externí odkaz:
https://doaj.org/article/7348d7aab02f4d87839686b6a126df57
Autor:
Salvatore Incontro, Javier Díaz-Alonso, Jillian Iafrati, Marta Vieira, Cedric S. Asensio, Vikaas S. Sohal, Katherine W. Roche, Kevin J. Bender, Roger A. Nicoll
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-21 (2018)
Calcium-calmodulin-dependent protein kinase II (CaMKII) is well known for its roles in synaptic plasticity. Using a series of molecular replacement experiments, the authors show that the kinase function of CaMKII is required for long-term plasticity
Externí odkaz:
https://doaj.org/article/5fb48f87db034bfe9e462aad3de3908e
Publikováno v:
Cell Reports, Vol 20, Iss 1, Pp 21-29 (2017)
Neuronal chloride levels are developmentally regulated. Early in life, high intracellular concentrations support chloride efflux and depolarization at GABAergic synapses. In mouse, intracellular chloride decreases over the first postnatal week in the
Externí odkaz:
https://doaj.org/article/7f6048c262a04de684977cb3bcf300ba
Autor:
Kenneth J. Burke, Kevin J. Bender
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
The axon is responsible for integrating synaptic signals, generating action potentials (APs), propagating those APs to downstream synapses and converting them into patterns of neurotransmitter vesicle release. This process is mediated by a rich assor
Externí odkaz:
https://doaj.org/article/53fcd66935ff4e079a1a6f6979a13f90
β-Arrestin-Dependent Dopaminergic Regulation of Calcium Channel Activity in the Axon Initial Segment
Autor:
Sungchil Yang, Roy Ben-Shalom, Misol Ahn, Alayna T. Liptak, Richard M. van Rijn, Jennifer L. Whistler, Kevin J. Bender
Publikováno v:
Cell Reports, Vol 16, Iss 6, Pp 1518-1526 (2016)
G-protein-coupled receptors (GPCRs) initiate a variety of signaling cascades, depending on effector coupling. β-arrestins, which were initially characterized by their ability to “arrest” GPCR signaling by uncoupling receptor and G protein, have
Externí odkaz:
https://doaj.org/article/d5266b88370841d78c47fdbf8112bf8d
Autor:
Salvatore Incontro, Javier Díaz-Alonso, Jillian Iafrati, Marta Vieira, Cedric S. Asensio, Vikaas S. Sohal, Katherine W. Roche, Kevin J. Bender, Roger A. Nicoll
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-2 (2018)
The originally published version of this Article contained errors in Figure 5, for which we apologise. In panel c, the scatter graph was inadvertently replaced with a scatter graph comprising a subset of data points from panel d. Furthermore, the leg
Externí odkaz:
https://doaj.org/article/285590a6c6aa43ccbe9bb83ced51b30c
Autor:
Elizabeth K. Unger, Kenneth J. Burke Jr., Cindy F. Yang, Kevin J. Bender, Patrick M. Fuller, Nirao M. Shah
Publikováno v:
Cell Reports, Vol 10, Iss 4, Pp 453-462 (2015)
Aromatase-expressing neuroendocrine neurons in the vertebrate male brain synthesize estradiol from circulating testosterone. This locally produced estradiol controls neural circuits underlying courtship vocalization, mating, aggression, and territory
Externí odkaz:
https://doaj.org/article/6c21e52e997c413e8ed508d9b5a01dd3
Autor:
Jonathan S Schor, Isabelle Gonzalez Montalvo, Perry WE Spratt, Rea J Brakaj, Jasmine A Stansil, Emily L Twedell, Kevin J Bender, Alexandra B Nelson
Publikováno v:
eLife, Vol 11 (2022)
Subthalamic nucleus deep brain stimulation (STN DBS) relieves many motor symptoms of Parkinson’s disease (PD), but its underlying therapeutic mechanisms remain unclear. Since its advent, three major theories have been proposed: (1) DBS inhibits the
Externí odkaz:
https://doaj.org/article/666d2c4e2e3b44e798b540be83165200