Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kevin J. Barrell"'
Autor:
Colin L. Honeybourne, Kevin J. Barrell
Publikováno v:
Journal of Porphyrins and Phthalocyanines. :569-584
The synthesis of three novel porphyrins (that are models for mesoporphyrin) requires the synthesis of eight new pyrroles, one new alkyl-3-oxohexanoate and two new dipyrromethanes. The new porphyrin free bases have hydrophobic substitution patterns di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f09044bf94076510a51a03003709d611
https://doi.org/10.1002/(sici)1099-1409(199908/10)3:6/7<569::aid-jpp176>3.0.co
https://doi.org/10.1002/(sici)1099-1409(199908/10)3:6/7<569::aid-jpp176>3.0.co
Autor:
Kevin J. Barrell, Colin L. Honeybourne
Publikováno v:
J. Mater. Chem.. 6:323-329
By a modification of the Jackson–MacDonald condensation between two symmetrically substituted dipyrrylmethanes, we have synthesised two porphyrin free-base amphiphiles and four metalloporphyrin amphiphiles all of which serve as models for the natur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aacd14171b604a0eb488c0e633e1742a
https://doi.org/10.1039/jm9960600323
https://doi.org/10.1039/jm9960600323
Publikováno v:
Chirality. 7:376-380
The (+)-, (−)-, and (±)-forms of 1- and 1,3-substituted 3-(4-aminophenyl)pyrrolidine-2,5-dione have been examined as inhibitors of P450AROM and P450CSCC. The inhibitory potency for P450AROM resided in the (+)-enantiomers of (1), (2), and (4) and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f9d4a06e6845884cda6d7016e568382
https://doi.org/10.1002/chir.530070511
https://doi.org/10.1002/chir.530070511
Publikováno v:
The Journal of pharmacy and pharmacology. 48(2)
3-(4′-Aminophenyl)pyrrolidine-2,5-dione (WSP3), a known reversible inhibitor of P450 aromatase, was modified using molecular graphics and our model of reversible inhibitor and substrate binding to resemble 10β-prop-2-ynylestr-4-ene-3,17-dione (PED
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f608a5a78564a29af62db7771df115fc
https://pubmed.ncbi.nlm.nih.gov/8935164
https://pubmed.ncbi.nlm.nih.gov/8935164
Publikováno v:
Chirality. 6(5)
The enantiomers of the aromatase inhibitors 3-(4-aminophenyl)-pyrrolidine-2,5-dione (WSP-3, II), its N-pentyl derivative (III), and the antifungal econazole (IV), all possessing a benzylic proton at the chiral centre, are rapidly racemised in vitro i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa993409734da9ffe298baf389f2c531
https://pubmed.ncbi.nlm.nih.gov/8068499
https://pubmed.ncbi.nlm.nih.gov/8068499
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :2549
Routes are described for the synthesis of 3-alkyl-3-(prop-2-ynyl)pyrrolidine-2,5-diones 5 and 6, which are not available by the literature method for the corresponding prop-2-enyl analogues, and 3-carboxy-3-(prop-2-ynyl)pyrrolidine-2,5-dione 7.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df0fba6a1209c916b5c52ed1bc7e55be
https://doi.org/10.1039/p19930002549
https://doi.org/10.1039/p19930002549