Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Kevin J. Kauffman"'
Autor:
Congxin Sun, Elena Seranova, Malkiel A. Cohen, Miruna Chipara, Jennie Roberts, Dewi Astuti, Adina M. Palhegyi, Animesh Acharjee, Lucia Sedlackova, Tetsushi Kataura, Elsje G. Otten, Prashanta K. Panda, Samuel Lara-Reyna, Miriam E. Korsgen, Kevin J. Kauffman, Alejandro Huerta-Uribe, Malgorzata Zatyka, Luiz F.S.E. Silva, Jorge Torresi, Shupei Zhang, Georgina W. Hughes, Carl Ward, Erich R. Kuechler, David Cartwright, Sergey Trushin, Eugenia Trushina, Gaurav Sahay, Yosef Buganim, Gareth G. Lavery, Joerg Gsponer, Daniel G. Anderson, Eva-Maria Frickel, Tatiana R. Rosenstock, Timothy Barrett, Oliver D.K. Maddocks, Daniel A. Tennant, Haoyi Wang, Rudolf Jaenisch, Viktor I. Korolchuk, Sovan Sarkar
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112372- (2023)
Summary: Autophagy is a homeostatic process critical for cellular survival, and its malfunction is implicated in human diseases including neurodegeneration. Loss of autophagy contributes to cytotoxicity and tissue degeneration, but the mechanistic un
Externí odkaz:
https://doaj.org/article/b83b8c0b9a4f4ed78cbd46982db1f23d
Autor:
Kevin J. Kauffman, Matthias A. Oberli, J. Robert Dorkin, Juan E. Hurtado, James C. Kaczmarek, Shivani Bhadani, Jeff Wyckoff, Robert Langer, Ana Jaklenec, Daniel G. Anderson
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 10, Iss , Pp 55-63 (2018)
mRNA therapeutics hold promise for the treatment of diseases requiring intracellular protein expression and for use in genome editing systems, but mRNA must transfect the desired tissue and cell type to be efficacious. Nanoparticle vectors that deliv
Externí odkaz:
https://doaj.org/article/e39d3fa298a14a7eb9f00028a6eb6d73
Autor:
Elisabeth H. Vollmann, Lizhi Cao, Aldo Amatucci, Taylor Reynolds, Stefan Hamann, Isin Dalkilic-Liddle, Thomas O. Cameron, Markus Hossbach, Kevin J. Kauffman, Faryal F. Mir, Daniel G. Anderson, Tatiana Novobrantseva, Victor Koteliansky, Tatiana Kisseleva, David Brenner, Jeremy Duffield, Linda C. Burkly
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 7, Iss C, Pp 314-323 (2017)
Fibrotic diseases contribute to 45% of deaths in the industrialized world, and therefore a better understanding of the pathophysiological mechanisms underlying tissue fibrosis is sorely needed. We aimed to identify novel modifiers of tissue fibrosis
Externí odkaz:
https://doaj.org/article/0a07061608884d5ebedd059c50812d16
Autor:
Patrick B F O'Connor, Victor Koteliansky, Robert Langer, Timofei S. Zatsepin, Pavel V. Baranov, Daniel G. Anderson, Maxim V. Gerashchenko, Kevin J. Kauffman, Vadim N. Gladyshev, Anna S. Fefilova, Charles A. Whittaker, Elena M. Smekalova, Roman L. Bogorad
Publikováno v:
Elsevier
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
© 2019 Translation is an essential biological process, and dysregulation is associated with a range of diseases including ribosomopathies, diabetes, and cancer. Here, we examine translation dysregulation in vivo using RNAi to knock down the m-subuni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3707e1b6cc7fc1075d06f75056c18207
https://doi.org/10.1016/j.omtn.2019.11.009
https://doi.org/10.1016/j.omtn.2019.11.009
Autor:
Congxin Sun, Elena Seranova, Malkiel A. Cohen, Miruna Chipara, Jennie Roberts, Adina M. Palhegyi, Animesh Acharjee, Lucia Sedlackova, Tetsushi Kataura, Elsje G. Otten, Prashanta K. Panda, Kevin J. Kauffman, Alejandro Huerta-Uribe, Malgorzata Zatyka, Luiz F.S.E. Silva, Jorge Torresi, Shupei Zhang, Carl Ward, Erich R. Kuechler, David Cartwright, Sergey Trushin, Eugenia Trushina, Gaurav Sahay, Yosef Buganim, Gareth G. Lavery, Joerg Gsponer, Daniel G. Anderson, Tatiana R. Rosenstock, Timothy Barrett, Oliver D.K. Maddocks, Daniel A. Tennant, Haoyi Wang, Rudolf Jaenisch, Viktor I. Korolchuk, Sovan Sarkar
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7419640be546f4be0c9fa45cfccf5da8
https://doi.org/10.2139/ssrn.4052958
https://doi.org/10.2139/ssrn.4052958
Autor:
Thiago Varga, Elsje G. Otten, Filippo Scialò, Gareth G. Lavery, Daniel G. Anderson, Shinji Saiki, Ryan Tasseff, Oliver D. K. Maddocks, David Cartwright, Niall S. Kenneth, Congxin Sun, Joerg Gsponer, Carl Ward, Luiz Felipe Souza E Silva, Rudolf Jaenisch, Tatiana R. Rosenstock, Manolis Papamichos-Chronakis, Malgorzata Zatyka, Kei-Ichi Ishikawa, Elena Seranova, Dorothea Maetzel, Sovan Sarkar, Masaya Imoto, Michael Lazarou, Haoyi Wang, David Shapira, Adina Maria Palhegyi, Kevin J. Kauffman, Rhoda Stefanatos, Malkiel A. Cohen, Lucia Sedlackova, Robert J. Isfort, Prashanta Kumar Panda, Tetsushi Kataura, Charles C. Bascom, Miruna Chipara, Gaurav Sahay, Alberto Sanz, Yosef Buganim, John Erich Oblong, Shupei Zhang, Satomi Miwa, Tong Zhang, Animesh Acharjee, Viktor I. Korolchuk, Jorge Torresi
Autophagy is an essential catabolic process that promotes the clearance of surplus or damaged intracellular components1. As a recycling process, autophagy is also important for the maintenance of cellular metabolites to aid metabolic homeostasis2. Lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f2832b802172e30ef5e271ca98c298b
https://doi.org/10.21203/rs.3.rs-659023/v1
https://doi.org/10.21203/rs.3.rs-659023/v1
Autor:
Carlos Fernández-Hernando, James E. Dahlman, Yang Jiao, Guangxin Li, Esther Lutgens, Jordan S. Pober, Michael Simons, Pascal J. H. Kusters, Binod Aryal, Daniel G. Anderson, Hongye Sun, Alberto Canfrán-Duque, Nicholas A. Cilfone, Jeffrey R. Gulcher, George Tellides, Sharvari Gujja, Pei-Yu Chen, Lele Sun, Rebecca Liu, Alfica Sehgal, Xinbo Zhang, Zheng Wang, Jose Malagon-Lopez, Martin A. Schwartz, Kevin J. Kauffman, Thomas Chittenden, Lingfeng Qin
Publikováno v:
Nature Metabolism, 1(9), 912-926. Springer Berlin
Atherosclerosis is a progressive vascular disease triggered by interplay between abnormal shear stress and endothelial lipid retention. A combination of these and, potentially, other factors leads to a chronic inflammatory response in the vessel wall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f565c7c7d33a2e28a9c71dd27d0af0
https://doi.org/10.1038/s42255-019-0102-3
https://doi.org/10.1038/s42255-019-0102-3
Autor:
Veronica Komoroski, Joe Wahle, Kevin J. Kauffman, Steve Sazinsky, Shantashri Vaidya, Igor Feldman, Denise Manfra, Ryan Phennicie, Michael A. Brehm, Tatiana Novobrantseva, Mohammad Zafari, Phuong Nguyen, Dominika Nowakowska
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Macrophages play an important role in cancer by modulating both the innate and adaptive parts of the immune system. In non-pathological conditions, multiple subsets of macrophages balance the immune response. In cancer, M2-like immune-supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5722b22f1026a7d5d1f26fb250e36498
https://doi.org/10.1136/jitc-2020-sitc2020.0862
https://doi.org/10.1136/jitc-2020-sitc2020.0862
Autor:
Frank Derosa, Kevin J. Kauffman, Daniel G. Anderson, Michael W. Heartlein, Jason L. Andresen, Owen S. Fenton, Manhao D. Zeng, Luke H. Rhym, Rebecca L. McClellan, James C. Kaczmarek
Publikováno v:
Angew Chem Int Ed Engl
RNAs are a promising class of therapeutics given their ability to regulate protein concentrations at the cellular level. Developing safe and effective strategies to deliver RNAs remains important for realizing their full clinical potential. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038555ced0ebd515c1250a26dfacc71d
https://doi.org/10.1002/anie.201809056
https://doi.org/10.1002/anie.201809056
Autor:
Jessica Ritter, Joe Wahle, Mohammad Zafari, Phuong Nguyen, Dominika Nowakowska, Denise Manfra, Kevin J. Kauffman, Igor Feldman, Steve Sazinsky, Ryan Phennicie, Brian O’Nuallain, Veronica Komoroski, Michael A. Brehm, Tatiana Novobrantseva
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A919-A919
BackgroundSuppressive myeloid cell populations in the tumor microenvironment (TME) are associated with worse survival of cancer patients and low effectiveness of T cell checkpoint inhibitors. Recently, several early clinical trials have produced posi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b3f0d0200d71f803335f36c546aab4b
https://doi.org/10.1136/jitc-2021-sitc2021.877
https://doi.org/10.1136/jitc-2021-sitc2021.877