Zobrazeno 1 - 10
of 175
pro vyhledávání: '"Kevin J Staley"'
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0172677 (2017)
Rodent organotypic hippocampal cultures spontaneously develop epileptiform activity after approximately 2 weeks in vitro and are increasingly used as a model of chronic post-traumatic epilepsy. However, organotypic cultures are maintained in an artif
Externí odkaz:
https://doaj.org/article/39be02068a53497abdd0a240baf69dfa
Autor:
Joseph Glykys, Kevin J Staley
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0158012 (2016)
The intraneuronal chloride concentration ([Cl-]i) is paramount for determining the polarity of signaling at GABAA synapses in the central nervous system. Sectioning hippocampal brain slices increases [Cl-]i in the superficial layers. It is not known
Externí odkaz:
https://doaj.org/article/fa21a521756a4a4c988641c25b2b57a1
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41108 (2012)
Kynurenic acid (KYNA), a classical ionotropic glutamate receptor antagonist is also purported to block the α7-subtype nicotinic acetylcholine receptor (α7* nAChR). Although many published studies cite this potential effect, few have studied it dire
Externí odkaz:
https://doaj.org/article/c08ba3fb438b418e8199b4168191c011
Autor:
Beth A. Costine-Bartell, Luis Martinez-Ramirez, Kieran Normoyle, Tawny Stinson, Kevin J. Staley, Kyle P. Lillis
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract A common point of failure in translation of preclinical neurological research to successful clinical trials comes in the giant leap from rodent models to humans. Non-human primates are phylogenetically close to humans, but cost and ethical c
Externí odkaz:
https://doaj.org/article/64c3f6ac5c2c440dbc03ef5e8ea7a0d5
Autor:
Sara K. Trowbridge, Lois O. Condie, Jessica R. Landers, Ann M. Bergin, Patricia E. Grant, Kalpathy Krishnamoorthy, Valerie Rofeberg, David Wypij, Kevin J. Staley, Janet S. Soul, for the Boston Bumetanide Trial Group
Publikováno v:
Annals of the Child Neurology Society, Vol 1, Iss 1, Pp 53-65 (2023)
Abstract Background Neonatal seizures are common, but the impact of neonatal seizures on long‐term neurologic outcomes remains unclear. We addressed this question by analyzing data from an early‐phase controlled trial of bumetanide to treat neona
Externí odkaz:
https://doaj.org/article/1de2c3ca8a59496b808e4f427b314c3a
Publikováno v:
Biomolecules, Vol 14, Iss 1, p 77 (2024)
GABA, the primary inhibitory neurotransmitter, stimulates GABAA receptors (GABAARs) to increase the chloride conductance of the cytosolic membrane. The driving forces for membrane chloride currents are determined by the local differences between intr
Externí odkaz:
https://doaj.org/article/a68879ae5f58441d972bfa05f88743dc
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101349- (2022)
Summary: Utilization of live animals for mechanistic study is challenging yet pivotal to elucidate pathogenesis of neurological diseases. Here, we present a protocol that employs cultured brain slices derived from adult mice to examine mRNA metabolis
Externí odkaz:
https://doaj.org/article/f7718a9ccfe74cd9b395e6317b2bc707
Publikováno v:
Brain
Seizure initiation is the least understood and most disabling element of epilepsy. Studies of ictogenesis require high speed recordings at cellular resolution in the area of seizure onset. However, in vivo seizure onset areas cannot be determined at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a588c907794040fefae04b67e7527c
https://doi.org/10.1093/brain/awab312
https://doi.org/10.1093/brain/awab312
Autor:
Annamaria Vezzani, Kevin J. Staley, Aristea S. Galanopoulou, Terence J. O'Brien, Harald Sontheimer, Brian D. Klein, H. Steve White, John A. Wolf, Wolfgang Löscher, Twyman Roy E, Karen S. Wilcox, Raimondo D'Ambrosio, Laura Lubbers, Vicky Whittemore
Publikováno v:
Epilepsia Open
Epilepsia Open, Vol 6, Iss 2, Pp 276-296 (2021)
Epilepsia Open, Vol 6, Iss 2, Pp 276-296 (2021)
Epilepsy is one of the most common chronic brain diseases and is often associated with cognitive, behavioral, or other medical conditions. The need for therapies that would prevent, ameliorate, or cure epilepsy and the attendant comorbidities is a pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf448e5675bffbaccf41799fd68c456
http://europepmc.org/articles/PMC8166793
http://europepmc.org/articles/PMC8166793
The amplitude of ictal activity is a defining feature of epileptic seizures, but the determinants of this amplitude have not been studied. Pathological synchronization of neuronal activity is assumed to be the main driver of increased ictal amplitude
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b54b8957134bb9d8fe2709f0099ed04e
https://doi.org/10.1101/2022.07.08.499193
https://doi.org/10.1101/2022.07.08.499193
